4.7 Article

Toward a Systematic Assessment of Sex Differences in Cystic Fibrosis

Related references

Note: Only part of the references are listed.
Article Immunology

Sex-biased expression of selected chromosome x-linked microRNAs with potent regulatory effect on the inflammatory response in children with cystic fibrosis: A preliminary pilot investigation

Maud Deny et al.

Summary: Previous studies have shown that there is a sex disparity in cystic fibrosis (CF) disease, with females experiencing more respiratory exacerbations and infections leading to shorter survival. The underlying mechanisms are still unclear, but this study suggests that X-linked miR-221-3p may play a role in sustaining higher inflammation in CF girls. The expression of this miRNA was found to be significantly higher in CF girls compared to CF boys, and it correlated positively with IL-1 beta.

FRONTIERS IN IMMUNOLOGY (2023)

Review Biochemistry & Molecular Biology

The Role of MMPs in the Era of CFTR Modulators: An Additional Target for Cystic Fibrosis Patients?

Renata Esposito et al.

Summary: Cystic fibrosis (CF) is a prevalent disease with significant lung remodeling and high morbidity and mortality worldwide. Imbalance of proteases and antiproteases, particularly matrix metalloproteases (MMPs), plays a role in CF pathogenesis. While CFTR modulator therapy has shown efficacy in most CF patients, alternative experimental drugs and targeting MMPs are being explored for non-responder patients.

BIOMOLECULES (2023)

Review Pharmacology & Pharmacy

G Protein-Coupled Estrogen Receptor GPER: Molecular Pharmacology and Therapeutic Applications

Jeffrey B. Arterburn et al.

Summary: The actions of estrogens and related estrogenic molecules are complex and multifaceted in both sexes. These molecules target pathways that produce and respond to estrogens, and multiple receptors are involved in the responses. In particular, the G protein-coupled estrogen receptor (GPER) plays important roles in physiological responses to estrogenic compounds and has therapeutic implications for various diseases.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY (2023)

Article Genetics & Heredity

Identification of hub genes associated with human cystic fibrosis: A Meta-analysis approach

Tithi S. Trivedi et al.

Summary: This study aimed to investigate the upregulated and downregulated genes in cystic fibrosis, and their involvement in related pathways. A protein-protein interaction network was constructed to identify hub genes related to this disease. Further analysis revealed the interactions of these hub genes with transcription factors and miRNAs. The findings contribute to a better understanding of cystic fibrosis pathophysiology.

HUMAN GENE (2023)

Article Pharmacology & Pharmacy

TMEM16A (ANO1) as a therapeutic target in cystic fibrosis

Luis J. Galietta

Summary: Cystic fibrosis is a genetic disease caused by the dysfunction of CFTR, a chloride channel expressed in epithelial cells. The loss of CFTR function leads to chronic bacterial infections and airway obstruction. Another chloride channel called TMEM16A may play a role in mucus hypersecretion, but further research is needed to confirm this relationship.

CURRENT OPINION IN PHARMACOLOGY (2022)

Article Multidisciplinary Sciences

Whole blood RNA-seq demonstrates an increased host immune response in individuals with cystic fibrosis who develop nontuberculous mycobacterial pulmonary disease

Miguel Dario Prieto et al.

Summary: This study found that patients with cystic fibrosis who develop non-tuberculous mycobacteria pulmonary disease (NTM-PD) exhibit enhanced innate immune responses, which is different from the non-cystic fibrosis population.

PLOS ONE (2022)

Review Medicine, Research & Experimental

Estrogens as regulator of hematopoietic stem cell, immune cells and bone biology

Rupali Sani Kumar et al.

Summary: Hematopoietic stem cells provide a continuous supply of all immune cells through proliferation and differentiation decisions, with these decisions being controlled by the local bone marrow environment and long-range signals. Female longevity seems to depend on the major female sex hormone, estrogen, under homeostasis and disease conditions. Estrogen has effects on HSC, immune cells, and bone biology, with Estradiol (E2) being extensively investigated while the effects of other estrogens such as E1, E3, and E4 are starting to be understood. The clinical effects of estrogen as hormone therapy on HSC and immune cells are also discussed.

LIFE SCIENCES (2021)

Article Multidisciplinary Sciences

Predicting tissue-specific gene expression from whole blood transcriptome

Mahashweta Basu et al.

Summary: This study demonstrates that an individual's whole blood transcriptome can predict tissue-specific expression levels for around 60% of genes across various tissues, with particularly high accuracy in skeletal muscle. Predictions based on blood transcriptome are almost as effective as actual tissue expression in identifying disease states for six different complex disorders, surpassing the traditional blood transcriptome approach. The development of TEEBoT provides a valuable tool for further research in other medical conditions.

SCIENCE ADVANCES (2021)

Review Pharmacology & Pharmacy

Cyclic nucleotide phosphodiesterase inhibitors as therapeutic interventions for cystic fibrosis

Mark J. Turner et al.

Summary: Cystic Fibrosis (CF) lung disease is caused by mutations in the CFTR gene that affect anion and fluid secretion. Studying members of the PDE family regulating CFTR-dependent secretion and the effects of PDE inhibitors on cyclic nucleotide-regulated functions.

PHARMACOLOGY & THERAPEUTICS (2021)

Review Respiratory System

Sex disparities in cystic fibrosis: review on the effect of female sex hormones on lung pathophysiology and outcomes

Grace Y. Lam et al.

Summary: This review focuses on the impact of female sex hormones on CF pulmonary outcomes, summarizing data from in vitro and in vivo experiments on how estrogen and progesterone may modify mucociliary clearance, immunity, and infection in the CF airways. The potential for novel sex hormone-related therapeutic interventions is also discussed.

ERJ OPEN RESEARCH (2021)

Article Respiratory System

Alternative chloride transport pathways as pharmacological targets for the treatment of cystic fibrosis

Roberto Quesada et al.

JOURNAL OF CYSTIC FIBROSIS (2020)

Letter Critical Care Medicine

Females with Cystic Fibrosis Demonstrate a Differential Response Profile to Ivacaftor Compared with Males

Katharine E. Secunda et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

Review Immunology

Biology of Interleukin-17 and Its Pathophysiological Significance in Sepsis

Yun Ge et al.

FRONTIERS IN IMMUNOLOGY (2020)

Review Immunology

CRAC Channels and Calcium Signaling in T Cell-Mediated Immunity

Martin Vaeth et al.

TRENDS IN IMMUNOLOGY (2020)

Review Biochemistry & Molecular Biology

Neutrophils life under estrogenic and xenoestrogenic control

Karolina Nowak et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2019)

Article Respiratory System

Sex differences in respiratory function

Antonella LoMauro et al.

BREATHE (2018)

Review Respiratory System

Increasing awareness of sex differences in airway diseases

Deepa Raghavan et al.

RESPIROLOGY (2016)

Article Biochemical Research Methods

MultiQC: summarize analysis results for multiple tools and samples in a single report

Philip Ewels et al.

BIOINFORMATICS (2016)

Article Genetics & Heredity

Prediction of the gene expression in normal lung tissue by the gene expression in blood

Justin W. Halloran et al.

BMC MEDICAL GENOMICS (2015)

Article Respiratory System

Future trends in cystic fibrosis demography in 34 European countries

Pierre-Regis Burgel et al.

EUROPEAN RESPIRATORY JOURNAL (2015)

Article Respiratory System

A contemporary survival analysis of individuals with cystic fibrosis: a cohort study

Anne L. Stephenson et al.

EUROPEAN RESPIRATORY JOURNAL (2015)

Article Respiratory System

An observational study of matrix metalloproteinase (MMP)-9 in cystic fibrosis

Graham Devereux et al.

JOURNAL OF CYSTIC FIBROSIS (2014)

Article Public, Environmental & Occupational Health

Gender Differences in Outcomes of Patients with Cystic Fibrosis

Cayce L. Harness-Brumley et al.

JOURNAL OF WOMENS HEALTH (2014)

Article Biotechnology & Applied Microbiology

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love et al.

GENOME BIOLOGY (2014)

Article Biochemical Research Methods

STAR: ultrafast universal RNA-seq aligner

Alexander Dobin et al.

BIOINFORMATICS (2013)

Article Medicine, General & Internal

Effect of Estrogen on Pseudomonas Mucoidy and Exacerbations in Cystic Fibrosis

Sanjay H. Chotirmall et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Article Oncology

A Gene Expression Signature from Peripheral Whole Blood for Stage I Lung Adenocarcinoma

Melissa Rotunno et al.

CANCER PREVENTION RESEARCH (2011)

Article Biotechnology & Applied Microbiology

Differential global gene expression in cystic fibrosis nasal and bronchial epithelium

Varrie Ogilvie et al.

GENOMICS (2011)

Article Multidisciplinary Sciences

REVIGO Summarizes and Visualizes Long Lists of Gene Ontology Terms

Fran Supek et al.

PLOS ONE (2011)

Article Biochemical Research Methods

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

Mark D. Robinson et al.

BIOINFORMATICS (2010)

Article Immunology

Estrogen receptor profiles in human peripheral blood lymphocytes

Marina Pierdominici et al.

IMMUNOLOGY LETTERS (2010)

Review Immunology

IL-17 and IL-22: siblings, not twins

Stefanie Eyerich et al.

TRENDS IN IMMUNOLOGY (2010)

Article Physiology

MMP9 modulates tight junction integrity and cell viability in human airway epithelia

Paola D. Vermeer et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2009)

Article Respiratory System

Sex disparities in effects of cystic fibrosis-related diabetes on clinical outcomes: A matched study

Robert J. Miller et al.

CANADIAN RESPIRATORY JOURNAL (2008)

Article Biochemistry & Molecular Biology

KEGG for linking genomes to life and the environment

Minoru Kanehisa et al.

NUCLEIC ACIDS RESEARCH (2008)

Review Hematology

cAMP signaling in leukocyte transendothelial migration

Magdalena J. Lorenowicz et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2007)

Article Biotechnology & Applied Microbiology

X chromosome gene expression in human tissues: Male and female comparisons

Zohreh Talebizadeh et al.

GENOMICS (2006)

Article Biochemistry & Molecular Biology

Respiratory epithelial gene expression in patients with mild and severe cystic fibrosis lung disease

Jerry M. Wright et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2006)

Article Biochemistry & Molecular Biology

Gene Expression Omnibus: NCBI gene expression and hybridization array data repository

R Edgar et al.

NUCLEIC ACIDS RESEARCH (2002)