Journal
JOURNAL OF PERSONALIZED MEDICINE
Volume 13, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/jpm13060924
Keywords
sex bias; gender gap; SABV; cystic fibrosis; differential gene expression; cAMP signaling pathway; estrogen signaling pathway
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In this study, we analyze the expression differences in whole blood transcriptomics between female and male CF patients to determine the pathways related to sex-biased genes and evaluate their potential influence on sex-specific effects in CF patients.
(1) Background: Cystic fibrosis (CF) is a disease with well-documented clinical differences between female and male patients. However, this gender gap is very poorly studied at the molecular level. (2) Methods: Expression differences in whole blood transcriptomics between female and male CF patients are analyzed in order to determine the pathways related to sex-biased genes and assess their potential influence on sex-specific effects in CF patients. (3) Results: We identify sex-biased genes in female and male CF patients and provide explanations for some sex-specific differences at the molecular level. (4) Conclusion: Genes in key pathways associated with CF are differentially expressed between sexes, and thus may account for the gender gap in morbidity and mortality in CF.
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