☆ 4.7 Article

The Tryptophan-Kynurenine Metabolic System Is Suppressed in Cuprizone-Induced Model of Demyelination Simulating Progressive Multiple Sclerosis

BIOMEDICINES (2023)

Related references

Note: Only part of the references are listed.

Review Clinical Neurology

The role of microglia in neuropsychiatric disorders and suicide

Ralf Brisch et al.

Summary: This review examines the potential role of microglial cells in neuroinflammation and neuropsychiatric disorders like schizophrenia, depression, and suicide. It discusses the interactions between microglia, astrocytes, and neurons in pathophysiological processes and explores the effects of drug therapy and electroconvulsive therapy on microglial cells. Finally, it also touches upon the evolutionary role of microglia in human lineage and how this understanding may shape perceptions of neuropsychiatric disorders.

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Neuroprotective Effect of Valproic Acid on Salicylate-Induced Tinnitus

Anji Song et al.

Summary: This study investigated the therapeutic effects of valproic acid (VPA) in a salicylate-induced tinnitus model. The results showed that pretreatment with VPA before salicylate treatment can attenuate the increased levels of NMDA receptor, intracellular reactive oxygen species (ROS), and apoptosis-related markers induced by salicylate. These findings provide evidence for the beneficial effects of VPA in the treatment of salicylate-induced temporary hearing loss and tinnitus.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection

Article Biochemistry & Molecular Biology

The Organization of Somatostatin-Immunoreactive Cells in the Visual Cortex of the Gerbil

Kyung-Min Kwon et al.

Summary: In this study, the organization of SST neurons in the Mongolian gerbil visual cortex was characterized using immunocytochemistry, quantitative analysis, and confocal microscopy. The results showed distinct features of SST neurons and provided some insight into their afferent circuitry in the gerbil VC. These findings may support future studies investigating the role of SST neurons in visual processing.

BIOMEDICINES (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Kisspeptin-10 Rescues Cholinergic Differentiated SHSY-5Y Cells from α-Synuclein-Induced Toxicity In Vitro

Christopher Simon et al.

Summary: This study discovers a neuropeptide, KP-10, that can alleviate the damage caused by amyloid-beta and alpha-synuclein in cholinergic neurons. KP-10 mitigates alpha-synuclein-induced toxicity in cholinergic neurons through preferential binding. Moreover, in vitro and in silico experiments support this observation.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection

Review Clinical Neurology

Modelling the neurodevelopmental pathogenesis in neuropsychiatric disorders. Bioactive kynurenines and their analogues as neuroprotective agents-in celebration of 80th birthday of Professor Peter Riederer

Masaru Tanaka et al.

Summary: The neurodevelopmental theory suggests that disruptions in brain development can lead to subsequent neuropsychiatric symptoms. Preclinical studies have shown that neurodevelopmental pathology plays a role in various psychiatric disorders and neurodegenerative diseases.

JOURNAL OF NEURAL TRANSMISSION (2022)

Add to Collection

Article Neurosciences

The functional and structural associations of aberrant microglial activity in major depressive disorder

Jasmine D. Cakmak et al.

Summary: This study provides preliminary evidence linking increased microglial activity with network-level dysfunction in treatment-resistant MDD, highlighting its relevance to the pathophysiology of depression.

JOURNAL OF PSYCHIATRY & NEUROSCIENCE (2022)

Add to Collection

Editorial Material Neurosciences

Functional interplay between central and autonomic nervous systems in human fear conditioning

Simone Battaglia et al.

TRENDS IN NEUROSCIENCES (2022)

Add to Collection

Article Clinical Neurology

Association between microglial activation and serum kynurenine pathway metabolites in multiple sclerosis patients

Maija Saraste et al.

Summary: This clinical study found an association between low serum 3-hydroxykynurenine levels and increased microglial activation in the brains of multiple sclerosis patients.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2022)

Add to Collection

Article Biochemistry & Molecular Biology

The Role of Hub and Spoke Regions in Theory of Mind in Early Alzheimer's Disease and Frontotemporal Dementia

Beatrice Orso et al.

Summary: The study revealed that the hubs of the ToM network are located in frontal regions in patients with MCI-AD and bvFTD, and the impact of spokes damage on ToM performance is mediated by the integrity of hubs. Damage to hubs has an impact on ToM performance independent from the integrity of spokes.

BIOMEDICINES (2022)

Add to Collection

Article Biochemistry & Molecular Biology

The Neurobiological Correlates of Gaze Perception in Healthy Individuals and Neurologic Patients

Simone Battaglia et al.

Summary: The ability to adaptively follow conspecific eye movements is crucial for establishing shared attention and survival. This article discusses the neural bases of gaze-cueing and the perception of gaze direction, as well as the interaction between contextual factors and attention shift. The concept of invariant representation is proposed as a valuable framework for future research in gaze perception.

BIOMEDICINES (2022)

Add to Collection

Editorial Material Biochemistry & Molecular Biology

Editorial of Special Issue 'Dissecting Neurological and Neuropsychiatric Diseases: Neurodegeneration and Neuroprotection'

Masaru Tanaka et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection

Article Psychiatry

Altered striatal functional connectivity and structural dysconnectivity in individuals with bipolar disorder: A resting state magnetic resonance imaging study

Charles Okanda Nyatega et al.

Summary: This study investigated functional abnormalities in the striatum among individuals with bipolar disorder (BD) compared to healthy controls (HC) using MRI evaluations. The findings revealed increased striatal connectivity in BD patients, along with gray matter deficits in specific brain regions. These results suggest that BD may be associated with both structural and functional brain alterations.

FRONTIERS IN PSYCHIATRY (2022)

Add to Collection

Article Psychology, Biological

Characterizing cardiac autonomic dynamics of fear learning in humans

Simone Battaglia et al.

Summary: Understanding the transient dynamics of the autonomic nervous system during fear learning is crucial for the treatment of fear-related disorders. In this study, a novel frequency-domain analysis of heart rate was performed to investigate the physiological processes underlying fear learning. The results revealed that fear learning led to a transient heart rate deceleration and increased parasympathetic (vagal) activity, indicating the involvement of cardiac vagal dynamics in fear learning.

PSYCHOPHYSIOLOGY (2022)

Add to Collection

Editorial Material Biochemistry & Molecular Biology

Integrating Armchair, Bench, and Bedside Research for Behavioral Neurology and Neuropsychiatry: Editorial

Masaru Tanaka et al.

BIOMEDICINES (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Brain Tumor Analysis Using Deep Learning and VGG-16 Ensembling Learning Approaches

Ayesha Younis et al.

Summary: This study aims to use deep learning and neural network classification algorithms to help detect and intervene in brain tumors, proposing an effective method for brain tumor detection using the VGG 16 architecture and MRI images. The method outperforms conventional approaches and achieves high accuracy.

APPLIED SCIENCES-BASEL (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Accuracy of EEG Biomarkers in the Detection of Clinical Outcome in Disorders of Consciousness after Severe Acquired Brain Injury: Preliminary Results of a Pilot Study Using a Machine Learning Approach

Francesco Di Gregorio et al.

Summary: The study found that functional connectivity and dominant frequency based on EEG can accurately predict clinical outcomes in patients with disorders of consciousness. This has significant implications for making appropriate rehabilitative decisions.

BIOMEDICINES (2022)

Add to Collection

Editorial Material Medicine, Research & Experimental

Translational biomedicine-oriented exploratory research on bioactive rotifer-specific biopolymers

Zsolt Datki et al.

Summary: There have been surprising discoveries in comprehensive biopolymer research, such as the description of new types of biopolymers and their expanded applications. The original work of our research group focuses on the discovery of a new biopolymer family called Rotimers, found in rotifers, which have the ability to inactivate and break down neurotoxic aggregates. Current studies show promising biodiversity and bioactivity of Rotimers, with potential applications in translational biomedicine.

ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE (2022)

Add to Collection

Article Psychiatry

Gray matter, white matter and cerebrospinal fluid abnormalities in Parkinson's disease: A voxel-based morphometry study

Charles Okanda Nyatega et al.

Summary: This study compared anatomical brain differences between PD patients and healthy controls using voxel-based morphometry (VBM). The results showed that PD patients had lower gray matter volumes in certain brain regions, lower white matter volumes in specific areas, and higher cerebrospinal fluid levels in a particular region compared to controls.

FRONTIERS IN PSYCHIATRY (2022)

Add to Collection

Article Cell Biology

Mesenchymal Stem Cells Ameliorate Cuprizone-Induced Demyelination by Targeting Oxidative Stress and Mitochondrial Dysfunction

Elham Shiri et al.

Summary: The transplantation of mesenchymal stem cells (MSCs) is shown to alleviate demyelination in a mouse model of multiple sclerosis (MS) by promoting antioxidant response, reducing oxidative stress, and improving mitochondrial homeostasis. This results in increased myelinated areas and fibers, as well as a decrease in astrogliosis and microgliosis in the corpus callosum. Furthermore, MSC therapy reverses the effects of copper chelator-induced oxidative stress and mitochondrial dysfunction in MS.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2021)

Add to Collection

Article Biochemical Research Methods

Simultaneous determination of 30 neurologically and metabolically important molecules: A sensitive and selective way to measure tyrosine and tryptophan pathway metabolites and other biomarkers in human serum and cerebrospinal fluid

Zsolt Galla et al.

Summary: This study presents a robust method for concurrent measurement of multiple molecules, which can aid in the diagnosis and understanding of metabolic and neurological disorders. The method meets EMA requirements and is suitable for sample determination in clinical laboratories.

JOURNAL OF CHROMATOGRAPHY A (2021)

Add to Collection

Review Pharmacology & Pharmacy

Addiction and the kynurenine pathway: A new dancing couple?

Nuria Morales-Puerto et al.

Summary: Drug use poses a serious threat to health systems worldwide, with the kynurenine pathway being of interest in relation to addictive behavior. Recent studies suggest that modulation of certain stages of this pathway can reduce, prevent, or abolish drug seeking-like behaviors.

PHARMACOLOGY & THERAPEUTICS (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Kisspeptin-8 Induces Anxiety-Like Behavior and Hypolocomotion by Activating the HPA Axis and Increasing GABA Release in the Nucleus Accumbens in Rats

Katalin Eszter Ibos et al.

Summary: Kp-8 treatment in rats resulted in decreased exploratory and spontaneous locomotion, increased anxiety-related behaviors, and activation of the reproductive axis through Kiss1r. The neurochemical changes in GABA and dopamine release further support the findings.

BIOMEDICINES (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Altered Dynamic Functional Connectivity of Cuneus in Schizophrenia Patients: A Resting-State fMRI Study

Charles Okanda Nyatega et al.

Summary: This study investigated dynamic functional connectivity in the cuneus between SZ patients and healthy controls based on rsfMRI data from the COBRE dataset. The results showed decreased mean strength connectivity between the cuneus and certain brain regions in SZ patients, suggesting that dynamic functional connectivity analysis could reveal patterns not evident in static functional connectivity, providing important insights into schizophrenia.

APPLIED SCIENCES-BASEL (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Functional Characterization of Spinocerebellar Ataxia Associated Dynorphin A Mutant Peptides

Andreas Lieb et al.

Summary: Mutations in the prodynorphin gene are associated with spinocerebellar ataxia type 23 (SCA23). Pathogenic missense mutations lead to elevated levels of mutant peptide with neurotoxic properties. The study showed that SCA23 DynA mutants decrease the potency of KOR activation, both in terms of G-protein dissociation and beta-arrestin recruitment. Molecular modeling suggests that this loss of function is due to disruption of critical interactions between DynA and the receptor.

BIOMEDICINES (2021)

Add to Collection

Article Multidisciplinary Sciences

Quinolinic acid is associated with cognitive deficits in schizophrenia but not major depressive disorder

Flurin Cathomas et al.

Summary: Tryptophan and its catabolites have been suggested to link immune system activation and neurotransmitter abnormalities with schizophrenia and major depressive disorder. This study found that patients with MDD had lower kynurenine and 3-hydroxy kynurenine levels, while patients with SZ showed a negative correlation between quinolinic acid and cognitive impairment severity. These results suggest dysregulation of the kynurenine pathway in MDD and SZ.

SCIENTIFIC REPORTS (2021)

Add to Collection

Editorial Material Biochemistry & Molecular Biology

Editorial of Special Issue Crosstalk between Depression, Anxiety, and Dementia: Comorbidity in Behavioral Neurology and Neuropsychiatry

Masaru Tanaka et al.

BIOMEDICINES (2021)

Add to Collection

Article Biochemistry & Molecular Biology

A Role for Xanthurenic Acid in the Control of Brain Dopaminergic Activity

Omar Taleb et al.

Summary: Xanthurenic acid (XA) is a metabolite of the kynurenine pathway synthesized in the brain from dietary or microbial tryptophan, suspected to modulate some pathophysiological mechanisms of neuropsychiatric and/or neurodegenerative diseases. Studies have shown that XA may play an important role in the endocrine system and could affect normal dopaminergic activity in the brain.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Review Immunology

Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease

Li-Ming Chen et al.

Summary: Inflammatory bowel disease (IBD) patients are at a higher risk of depression, which can negatively impact disease prognosis and quality of life. The key metabolic enzyme indoleamine 2,3-dioxygenase (IDO) in the tryptophan-kynurenine metabolic pathway is activated in the inflammatory environment, leading to potentially neurologically active metabolites associated with inflammation-induced depression.

JOURNAL OF NEUROINFLAMMATION (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Neurodegeneration in Multiple Sclerosis: Symptoms of Silent Progression, Biomarkers and Neuroprotective Therapy-Kynurenines Are Important Players

Daniel Sandi et al.

Summary: Neurodegeneration plays a crucial role in the pathogenesis of multiple sclerosis, leading to progression, pathopsychological disturbances, and optic neuropathy. The kynurenine pathway has been highlighted as a potential therapeutic target for neuroprotective drugs in MS, with promising data emerging from clinical evaluations. Further research on the pathway is expected to provide concrete results for everyday medicine in the future.

MOLECULES (2021)

Add to Collection

Review Clinical Neurology

Secondary Progressive Multiple Sclerosis New Insights

Bruce A. C. Cree et al.

Summary: In most cases, multiple sclerosis begins with a relapsing-remitting course followed by secondary progressive MS (SMPS), and there are major differences between RRMS and SPMS in terms of treatment response and diagnosis. However, clear criteria marking the transition from RRMS to SPMS have not been established yet. Early identification of SPMS will require tools that, along with appropriate treatment, may lead to better long-term outcomes.

NEUROLOGY (2021)

Add to Collection

Article Multidisciplinary Sciences

Cuprizone markedly decreases kynurenic acid levels in the rodent brain tissue and plasma

Helga Polyak et al.

Summary: The study aimed to measure the metabolites of the KP in CPZ treated animals, with a focus on KYNA levels. Results showed a marked reduction of KYNA in the demyelinating phase, suggesting a potential involvement of the KP in the pathomechanism of MS in a non-immune mediated model.

HELIYON (2021)

Add to Collection

Review Geriatrics & Gerontology

Kynurenine pathway and human systems

Abdulla A. -B. Badawy

EXPERIMENTAL GERONTOLOGY (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Exploring the Etiological Links behind Neurodegenerative Diseases: Inflammatory Cytokines and Bioactive Kynurenines

Masaru Tanaka et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Add to Collection

Review Cell Biology

The Cuprizone Model: Dos and Do Nots

Jiangshan Zhan et al.

CELLS (2020)

Add to Collection

Review Cell Biology

Kynurenines in the Pathogenesis of Multiple Sclerosis: Therapeutic Perspectives

Tamas Biernacki et al.

CELLS (2020)

Add to Collection

Article Chemistry, Analytical

A validated UHPLC-MS method for tryptophan metabolites: Application in the diagnosis of multiple sclerosis

Ferenc Tomosi et al.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2020)

Add to Collection

Article Clinical Neurology

Rising prevalence of multiple sclerosis worldwide: Insights from the Atlas of MS, third edition

Clare Walton et al.

MULTIPLE SCLEROSIS JOURNAL (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Neuronal Proteins as Targets of 3-Hydroxykynurenine: Implications in Neurodegenerative Diseases

Andrea Capucciati et al.

ACS CHEMICAL NEUROSCIENCE (2019)

Add to Collection

Article Health Care Sciences & Services

Young adults' adjustment to a recent diagnosis of multiple sclerosis: The role of identity satisfaction and self-efficacy

Emanuela Calandri et al.

DISABILITY AND HEALTH JOURNAL (2019)

Add to Collection

Article Cell Biology

Laquinimod Supports Remyelination in Non-Supportive Environments

Stella Nyamoya et al.

CELLS (2019)

Add to Collection

Review Behavioral Sciences

Behavioural phenotypes in the cuprizone model of central nervous system demyelination

Monokesh K. Sen et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2019)

Add to Collection

Article Medicine, Research & Experimental

Hypothesis kynurenic and quinolinic acids: The main players of the kynurenine pathway and opponents in inflammatory disease

Abdulla A-B. Badawy

MEDICAL HYPOTHESES (2018)

Add to Collection

Review Clinical Neurology

Multiple sclerosis: experimental models and reality

Hans Lassmann et al.

ACTA NEUROPATHOLOGICA (2017)

Add to Collection

Review Biochemistry & Molecular Biology

Excitotoxins, Mitochondrial and Redox Disturbances in Multiple Sclerosis

Cecilia Rajda et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Add to Collection

Article Immunology

Amino Acid Catabolism in Multiple Sclerosis Affects Immune Homeostasis

Laura Negrotto et al.

JOURNAL OF IMMUNOLOGY (2017)

Add to Collection

Review Chemistry, Analytical

Chromatographic analysis of tryptophan metabolites

Ilona Sadok et al.

JOURNAL OF SEPARATION SCIENCE (2017)

Add to Collection

Review Neurosciences

Kynurenine pathway metabolites and enzymes involved in redox reactions

D. Gonzalez Esquivel et al.

NEUROPHARMACOLOGY (2017)

Add to Collection

Review Neurosciences

Recent evidence for an expanded role of the kynurenine pathway of tryptophan metabolism in neurological diseases

Michael D. Lovelace et al.

NEUROPHARMACOLOGY (2017)

Add to Collection

Article Multidisciplinary Sciences

Kynurenine pathway metabolomics predicts and provides mechanistic insight into multiple sclerosis progression

Chai K. Lim et al.

SCIENTIFIC REPORTS (2017)

Add to Collection

Article Clinical Neurology

Prevalence of of cognitive impairment among Hungarian patients with relapsing-remitting multiple sclerosis and clinically isolated syndrome

Sandi Daniel et al.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2017)

Add to Collection

Review Clinical Neurology

Multiple sclerosis animal models: a clinical and histopathological perspective

Markus Kipp et al.

BRAIN PATHOLOGY (2017)

Add to Collection

Article Psychiatry

Microglial Activity in People at Ultra High Risk of Psychosis and in Schizophrenia: An [C-11]PBR28 PET Brain Imaging Study

Peter S. Bloomfield et al.

AMERICAN JOURNAL OF PSYCHIATRY (2016)

Add to Collection

Editorial Material Multidisciplinary Sciences

IS THERE A REPRODUCIBILITY CRISIS?

Monya Baker

NATURE (2016)

Add to Collection

Review Biochemistry & Molecular Biology

Kynurenines and Multiple Sclerosis: The Dialogue between the Immune System and the Central Nervous System

Cecilia Rajda et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)

Add to Collection

Review Biochemistry & Molecular Biology

Changing the Face of Kynurenines and Neurotoxicity: Therapeutic Considerations

Zsuzsanna Bohar et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)

Add to Collection

Article Immunology

Inefficient clearance of myelin debris by microglia impairs remyelinating processes

Antoine Lampron et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2015)

Add to Collection

Article Biochemistry & Molecular Biology

Free-radical scavenging by tryptophan and its metabolites through electron transfer based processes

Adriana Perez-Gonzalez et al.

JOURNAL OF MOLECULAR MODELING (2015)

Add to Collection

Article Chemistry, Inorganic & Nuclear

Iron chelation and redox chemistry of anthranilic acid and 3-hydroxyanthranilic acid: A comparison of two structurally related kynurenine pathway metabolites to obtain improved insights into their potential role in neurological disease development

Vladimir Chobot et al.

JOURNAL OF ORGANOMETALLIC CHEMISTRY (2015)

Add to Collection

Article Behavioral Sciences

Neuropeptide AF induces anxiety-like and antidepressant-like behavior in mice

Miklos Palotai et al.

BEHAVIOURAL BRAIN RESEARCH (2014)

Add to Collection

Review Behavioral Sciences

Cellular and molecular neuropathology of the cuprizone mouse model: Clinical relevance for multiple sclerosis

Jelle Praet et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2014)

Add to Collection

Article Biochemistry & Molecular Biology

Short analogs and mimetics of human urocortin 3 display antidepressant effects in vivo

Kinga Rakosi et al.

PEPTIDES (2014)

Add to Collection

Review Neurosciences

Glial response during cuprizone-induced de- and remyelination in the CNS: lessons learned

Viktoria Gudi et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2014)

Add to Collection

Article Anatomy & Morphology

Regional regulation of glutamate signaling during cuprizone-induced demyelination in the brain

Abolfazl Azami Tameh et al.

ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER (2013)

Add to Collection

Article Clinical Neurology

Hippocampal Demyelination and Memory Dysfunction are Associated with Increased Levels of the Neuronal microRNA miR-124 and Reduced AMPA Receptors

Ranjan Dutta et al.

ANNALS OF NEUROLOGY (2013)

Add to Collection

Article Clinical Neurology

Astrocytes regulate myelin clearance through recruitment of microglia during cuprizone-induced demyelination

Thomas Skripuletz et al.

BRAIN (2013)

Add to Collection

Article Cell Biology

Short-Term Cuprizone Feeding Induces Selective Amino Acid Deprivation with Concomitant Activation of an Integrated Stress Response in Oligodendrocytes

Johannes Goldberg et al.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2013)

Add to Collection

Article Immunology

Distribution of oligodendrocyte loss and mitochondrial toxicity in the cuprizone-induced experimental demyelination model

P. Acs et al.

JOURNAL OF NEUROIMMUNOLOGY (2013)

Add to Collection

Review Biotechnology & Applied Microbiology

Kynurenines in the CNS: recent advances and new questions

Laszlo Vecsei et al.

NATURE REVIEWS DRUG DISCOVERY (2013)

Add to Collection

Review Biochemistry & Molecular Biology

Quinolinic acid, the inescapable neurotoxin

Gilles J. Guillemin

FEBS JOURNAL (2012)

Add to Collection

Review Clinical Neurology

Progressive multiple sclerosis: pathology and pathogenesis

Hans Lassmann et al.

NATURE REVIEWS NEUROLOGY (2012)

Add to Collection

Review Neurosciences

Kynurenines in the mammalian brain: when physiology meets pathology

Robert Schwarcz et al.

NATURE REVIEWS NEUROSCIENCE (2012)

Add to Collection

Article Multidisciplinary Sciences

The Antioxidant Role of Xanthurenic Acid in the Aedes aegypti Midgut during Digestion of a Blood Meal

Vitor L. A. Lima et al.

PLOS ONE (2012)

Add to Collection

Article Behavioral Sciences

Effects of the growth hormone-releasing hormone (GH-RH) antagonist on brain functions in mice

Gyula Telegdy et al.

BEHAVIOURAL BRAIN RESEARCH (2011)

Add to Collection

Article Neurosciences

Antidepressant-like effects of urocortin 3 fragments

M. Tanaka et al.

BRAIN RESEARCH BULLETIN (2011)

Add to Collection

Review Cell Biology

Endogenous neuroprotection in chronic neurodegenerative disorders: with particular regard to the kynurenines

Denes Zadori et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2011)

Add to Collection

Article

Safety and Immunological Effects of Mesenchymal Stem Cell Transplantation in Patients With Multiple Sclerosis and Amyotrophic Lateral Sclerosis

Dimitrios Karussis et al.

ARCHIVES OF NEUROLOGY (2010)

Add to Collection

Article Neurosciences

Dynamic Expression of Cx47 in Mouse Brain Development and in the Cuprizone Model of Myelin Plasticity

Rosalba Parenti et al.

GLIA (2010)

Add to Collection

Article Neurosciences

17β-Estradiol and Progesterone Prevent Cuprizone Provoked Demyelination of Corpus Callosum in Male Mice

Peter Acs et al.

GLIA (2009)

Add to Collection

Article Neurosciences

Low sociability is associated with reduced size of the corpus callosum in the BALB/cJ inbred mouse strain

Andrew H. Fairless et al.

BRAIN RESEARCH (2008)

Add to Collection

Review Biochemistry & Molecular Biology

Mitochondrial copper metabolism and delivery to cytochrome c oxidase

Darryl Horn et al.

IUBMB LIFE (2008)

Add to Collection

Article Biochemistry & Molecular Biology

Activation of Inflammatory Response by a Combination of Growth Factors in Cuprizone-Induced Demyelinated Brain Leads to Myelin Repair

Juan Carlos Biancotti et al.

NEUROCHEMICAL RESEARCH (2008)

Add to Collection

Article Psychiatry

Quetiapine alleviates the cuprizone-induced white matter pathology in the brain of C57BL/6 mouse

Yanbo Zhang et al.

SCHIZOPHRENIA RESEARCH (2008)

Add to Collection

Article Clinical Neurology

Astrocytic activation in relation to inflammatory markers during clinical exacerbation of relapsing-remitting multiple sclerosis

K. Rejdak et al.

JOURNAL OF NEURAL TRANSMISSION (2007)

Add to Collection

Review Immunology

The involvement of mitochondria in the pathogenesis of multiple sclerosis

Bernadette Kalman et al.

JOURNAL OF NEUROIMMUNOLOGY (2007)

Add to Collection

Review Medicine, General & Internal

Medical progress: Multiple sclerosis - The plaque and its pathogenesis

EM Frohman et al.

NEW ENGLAND JOURNAL OF MEDICINE (2006)

Add to Collection

Article Neurosciences

Demyelination increases radial diffusivity in corpus callosum of mouse brain

SK Song et al.

NEUROIMAGE (2005)

Add to Collection

Review Endocrinology & Metabolism

Oligodendrocytes and ischemic brain injury

D Dewar et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2003)

Add to Collection

Article Medicine, Research & Experimental

Kynurenines and the respiratory parameters on rat heart mitochondria

H Baran et al.

LIFE SCIENCES (2003)

Add to Collection

Article Biochemistry & Molecular Biology

Mammalian copper chaperone Cox17p has an essential role in activation of cytochrome c oxidase and embryonic development

Y Takahashi et al.

MOLECULAR AND CELLULAR BIOLOGY (2002)

Add to Collection

Article Neurosciences

Decreased level of kynurenic acid in cerebrospinal fluid of relapsing-onset multiple sclerosis patients

K Rejdak et al.

NEUROSCIENCE LETTERS (2002)

Add to Collection

Article Biochemistry & Molecular Biology

Effects of systemic and central nervous system localized inflammation on the contributions of metabolic precursors to the L-kynurenine and quinolinic acid pools in brain

T Kita et al.

JOURNAL OF NEUROCHEMISTRY (2002)

Add to Collection

© Peeref 2019-2024. All rights reserved.