☆ 4.7 Article

Hydrogen Sulfide Inhibited Sympathetic Activation in D-Galactose-Induced Aging Rats by Upregulating Klotho and Inhibiting Inflammation in the Paraventricular Nucleus

BIOMEDICINES (2023)

Related references

Note: Only part of the references are listed.

Article Medicine, Research & Experimental

Hydrogen sulfide ameliorated preeclampsia via suppression of toll-like receptor 4-activated inflammation in the rostral ventrolateral medulla of rats

Jiexian Du et al.

Summary: This study suggests that inflammation in the RVLM caused by microglial activation may contribute to the progression of preeclampsia (PE) via an overactive sympathetic system. Hydrogen sulfide (H2S) could reduce PE by inhibiting inflammation in the RVLM. These findings might provide a new target for the treatment of PE.

BIOMEDICINE & PHARMACOTHERAPY (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Hydrogen sulfide alleviates particulate matter-induced emphysema and airway inflammation by suppressing ferroptosis

Ying Wang et al.

Summary: This study found that H2S alleviates PM-induced emphysema and airway inflammation by restoring redox balance and inhibiting ferroptosis through regulating the Nrf2-PPAR-ferritinophagy signaling pathway.

FREE RADICAL BIOLOGY AND MEDICINE (2022)

Add to Collection

Article Biochemistry & Molecular Biology

The renin-angiotensin system and cardiovascular autonomic control in aging

Amanda J. Miller et al.

Summary: Aging is the greatest risk factor for developing hypertension and cardiovascular-related diseases, with dysfunction of organ systems and an imbalance in the autonomic nervous system playing key roles in age-related cardiovascular risk. The renin-angiotensin system is an important hormonal modulator in cardiovascular autonomic control during aging, with current research focusing on angiotensin II versus angiotensin-(1-7) pathways and pharmacological treatment strategies targeting this system for future studies.

PEPTIDES (2022)

Add to Collection

Article Genetics & Heredity

Pcsk6 Deficiency Promotes Cardiomyocyte Senescence by Modulating Ddit3-Mediated ER Stress

Wenxing Zhan et al.

Summary: PCSK6 expression is decreased in cardiac aging and it modulates cardiomyocyte senescence possibly via DDIT3-mediated endoplasmic reticulum stress.

GENES (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Hydrogen Sulfide Inhibits Ferroptosis in Cardiomyocytes to Protect Cardiac Function in Aging Rats

Zihui Liang et al.

Summary: The decline in cardiac function and remodeling in elderly individuals is associated with decreased endogenous H2S levels and cardiomyocyte ferroptosis. The protective effects of exogenous H2S on cardiac function may be attributed to the inhibition of cardiomyocyte ferroptosis and regulation of iron metabolism. This research highlights the importance of H2S and iron homeostasis in maintaining cardiac function during aging.

FRONTIERS IN MOLECULAR BIOSCIENCES (2022)

Add to Collection

Article Cardiac & Cardiovascular Systems

Association between serum klotho levels and cardiovascular disease risk factors in older adults

Jaeho Lee et al.

Summary: This study aimed to explore the association between circulating serum klotho levels and risk factors for CVD in adults. The results showed that lower serum klotho levels were associated with high BMI, smoking, alcohol consumption, and lipid parameters (triglycerides and total cholesterol).

BMC CARDIOVASCULAR DISORDERS (2022)

Add to Collection

Article Cardiac & Cardiovascular Systems

Deficiency of cystathionine gamma-lyase promotes aortic elastolysis and medial degeneration in aged mice

Jiechun Zhu et al.

Summary: This study revealed the involvement of the CSE/H2S system in the pathogenesis of aortic elastolysis and medial degeneration by maintaining the inactive form of matrix metalloproteinases (MMPs), suggesting that the CSE/H2S system can be a target for the prevention of age-related medial degeneration and treatment of aortic aneurysm.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2022)

Add to Collection

Article Materials Science, Biomaterials

Hydrogen sulfide releasing hydrogel for alleviating cardiac inflammation and protecting against myocardial ischemia-reperfusion injury

Qi Zhang et al.

Summary: A new H2S-releasing hydrogel system significantly improved microvascular obstruction, prevented myocardial fibrosis, and attenuated cardiac inflammation in an experimental I/R model of rats. The novel H2S-releasing hydrogel represents a promising therapeutic strategy targeting myocardial ischemia-reperfusion injury.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

Add to Collection

Review Urology & Nephrology

Klotho in Clinical Nephrology Diagnostic and Therapeutic Implications

Javier A. Neyra et al.

Summary: Klotho, a membrane protein that serves as a coreceptor for FGF23, is essential for maintaining organ function and preventing multiorgan failure. Systemic Klotho deficiency is commonly associated with kidney diseases. While Klotho shows promise in clinical applications, further research and large prospective human studies are needed to fully understand its diagnostic and therapeutic potential.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)

Add to Collection

Article Cell Biology

Hydrogen sulfide and mesenchymal stem cells-extracted microvesicles attenuate LPS-induced Alzheimer's disease

Basma E. Aboulhoda et al.

Summary: The study showed that miR-155 plays a crucial role in regulating the neuro-inflammatory state and cognitive function in LPS-induced Alzheimer's disease. Treatment with microvesicles and hydrogen sulfide can attenuate inflammation, decrease levels of miR-155 and pAkt, and enhance antioxidant capacity by increasing catalase enzyme activity.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

Add to Collection

Article Agriculture, Multidisciplinary

Ameliorative Effect of Dietary Tryptophan on Neurodegeneration and Inflammation in D-Galactose-Induced Aging Mice with the Potential Mechanism Relying on AMPK/SIRT1/PGC-1α Pathway and Gut Microbiota

Jia Yin et al.

Summary: The study found that dietary tryptophan can improve intestinal inflammation and oxidative stress in aging mice through multiple pathways, as well as increase the levels of indoles in colon contents. Additionally, the tryptophan diet can increase the relative abundance of certain probiotics and improve neurodegeneration and neuroinflammation by regulating multiple signaling pathways.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

Add to Collection

Article Cell Biology

YAP prevents premature senescence of astrocytes and cognitive decline of Alzheimer's disease through regulating CDK6 signaling

Xingxing Xu et al.

Summary: In this study, YAP was found to be downregulated and inactivated in astrocytes of aging and AD model mice, leading to premature senescence of astrocytes. The expression of CDK6 was decreased in YAP knockout astrocytes, and overexpression of CDK6 partially rescued YAP knockout-induced senescence of astrocytes. Activation of YAP signaling by XMU-MP-1 partially rescued astrocyte senescence and improved cognitive function in AD model mice and aging mice.

AGING CELL (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Comparison of Resveratrol Supplementation and Energy Restriction Effects on Sympathetic Nervous System Activity and Vascular Reactivity: A Randomized Clinical Trial

Gustavo Henrique Ferreira Goncalinho et al.

Summary: The study suggests that resveratrol (RSV) does not improve cardiometabolic risk factors, sympathetic activity, and endothelial function, while energy restriction (ER) can decrease plasma noradrenaline, waist circumference, and improve blood lipids without affecting endothelial function. Plasma noradrenaline is positively correlated with nitrate-mediated vasodilation.

MOLECULES (2021)

Add to Collection

Review Neurosciences

Cellular senescence at the crossroads of inflammation and Alzheimer's disease

Ana Guerrero et al.

Summary: This article highlights the role of cellular senescence as a driver of the aging phenotype and discusses the current evidence connecting senescence with AD and neurodegeneration.

TRENDS IN NEUROSCIENCES (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Advanced Glycation End Products Increase Salivary Gland Hypofunction in d-Galactose-Induced Aging Rats and Its Prevention by Physical Exercise

Woo Kwon Jung et al.

Summary: A declined salivary gland function is commonly observed in elderly people, believed to be contributed by AGEs. Physical exercise has been shown to suppress age-related salivary changes and provide a beneficial option for age-related salivary hypofunction.

CURRENT ISSUES IN MOLECULAR BIOLOGY (2021)

Add to Collection

Review Pharmacology & Pharmacy

Klotho as Potential Autophagy Regulator and Therapeutic Target

Hongjing Zhou et al.

Summary: Klotho protein can delay aging and is associated with various aging-related diseases. By increasing Klotho expression, therapeutic effects can be achieved for these diseases, as Klotho plays a role in regulating the autophagic process.

FRONTIERS IN PHARMACOLOGY (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention

Xudong Zhu et al.

Summary: Significant progress has been made in ageing research, with a focus on epigenetic dynamics and immunometabolic reprogramming in relation to cell senescence. These hotspots not only shape cell identity, but also play a role in cell fate determination. Potential therapeutic interventions targeting cell senescence and regulatory mechanisms using state-of-the-art techniques are discussed.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Resveratrol and organic selenium-rich fermented milk reduces d-galactose-induced cognitive dysfunction in mice

Zhen Wu et al.

Summary: Dietary intervention with functional fermented milk rich in resveratrol and organic selenium has shown promising effects in improving cognitive function and increasing hippocampal neurogenesis in d-galactose model mice. Walnut diets with dairy products can help maintain the expression levels of key proteins related to neurotrophic signaling pathways in the hippocampus. These findings suggest the potential of yogurt rich in resveratrol and organic selenium in treating age-related diseases.

FOOD & FUNCTION (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Regulation of inflammation as an anti-aging intervention

Joana Neves et al.

FEBS JOURNAL (2020)

Add to Collection

Review Genetics & Heredity

The genetics of human ageing

David Melzer et al.

NATURE REVIEWS GENETICS (2020)

Add to Collection

Review Cell Biology

Ageing, age-related diseases and oxidative stress: What to do next?

Jiao Luo et al.

AGEING RESEARCH REVIEWS (2020)

Add to Collection

Article Geriatrics & Gerontology

Regulatory Effect of Anwulignan on the Immune Function Through Its Antioxidation and Anti-Apoptosis in D-Galactose-Induced Aging Mice

Xin Li et al.

CLINICAL INTERVENTIONS IN AGING (2020)

Add to Collection

Article Pharmacology & Pharmacy

Calcitriol ameliorated autonomic dysfunction and hypertension by down-regulating inflammation and oxidative stress in the paraventricular nucleus of SHR

Meng-Lu Xu et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Hydrogen sulfide attenuates renal fibrosis by inducing TET-dependent DNA demethylation on Klotho promoter

Yulu Gu et al.

FASEB JOURNAL (2020)

Add to Collection

Article Cell Biology

Klotho overexpression improves amyloid-beta clearance and cognition in the APP/PS1 mouse model of Alzheimer's disease

Yue Zhao et al.

AGING CELL (2020)

Add to Collection

Review Medicine, Research & Experimental

Brain angiotensin converting enzyme-2 in central cardiovascular regulation

Mazher Mohammed et al.

CLINICAL SCIENCE (2020)

Add to Collection

Article Pharmacology & Pharmacy

Hydrogen Sulfide Attenuated Angiotensin II-Induced Sympathetic Excitation in Offspring of Renovascular Hypertensive Rats

Xiaohong Feng et al.

FRONTIERS IN PHARMACOLOGY (2020)

Add to Collection

Article Multidisciplinary Sciences

L1 drives IFN in senescent cells and promotes age-associated inflammation

Marco De Cecco et al.

NATURE (2019)

Add to Collection

Review Multidisciplinary Sciences

From discoveries in ageing research to therapeutics for healthy ageing

Judith Campisi et al.

NATURE (2019)

Add to Collection

Article Physiology

Parental Renovascular Hypertension-Induced Autonomic Dysfunction in Male Offspring Is Improved by Prenatal or Postnatal Treatment With Hydrogen Sulfide

Qi Guo et al.

FRONTIERS IN PHYSIOLOGY (2019)

Add to Collection

Article Genetics & Heredity

Autophagy plays a critical role in Klotho gene deficiency-induced arterial stiffening and hypertension

Kai Chen et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2019)

Add to Collection

Article Geriatrics & Gerontology

Lower Plasma Klotho Concentrations Are Associated with Vascular Dementia but Not Late-Onset Alzheimer's Disease

Gloria Brombo et al.

GERONTOLOGY (2018)

Add to Collection

Article Cell Biology

Exercise training augments Sirt1-signaling and attenuates cardiac inflammation in D-galactose induced-aging rats

Wei-Kung Chen et al.

AGING-US (2018)

Add to Collection

Article Peripheral Vascular Disease

Klotho Ameliorates Medullary Fibrosis and Pressure Natriuresis in Hypertensive Rat Kidneys

Tsuneo Takenaka et al.

HYPERTENSION (2018)

Add to Collection

Article Cell Biology

H2S Donor NaHS Changes the Production of Endogenous H2S and NO in D-Galactose-Induced Accelerated Ageing

Wei Wu et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2017)

Add to Collection

Review Rehabilitation

Exercise training-induced modification in autonomic nervous system: An update for cardiac patients

Florent Besnier et al.

ANNALS OF PHYSICAL AND REHABILITATION MEDICINE (2017)

Add to Collection

Article Peripheral Vascular Disease

Maternal Renovascular Hypertensive Rats Treatment With Hydrogen Sulfide Increased the Methylation of AT1b Gene in Offspring

Qi Guo et al.

AMERICAN JOURNAL OF HYPERTENSION (2017)

Add to Collection

Article Medicine, Research & Experimental

Qing'E formula alleviates the aging process in D-galactose-induced aging mice

Lin Zhong et al.

BIOMEDICAL REPORTS (2016)

Add to Collection

Article Peripheral Vascular Disease

Microglia Participate in Neurogenic Regulation of Hypertension

Xiao Z. Shen et al.

HYPERTENSION (2015)

Add to Collection

Review Oncology

Klotho: a novel biomarker for cancer

Xiangxiang Zhou et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2015)

Add to Collection

Article Peripheral Vascular Disease

Aging Enhances Autonomic Support of Blood Pressure in Women

Jill N. Barnes et al.

HYPERTENSION (2014)

Add to Collection

Article Geriatrics & Gerontology

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

Claudio Franceschi et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2014)

Add to Collection

Review Physiology

Sympathetic Neural Regulation of Blood Pressure: Influences of Sex and Aging

E. C. J. Hart et al.

PHYSIOLOGY (2014)

Add to Collection

Article Biochemistry & Molecular Biology

Hydrogen Sulfide Mitigates Cardiac Remodeling During Myocardial Infarction via Improvement of Angiogenesis

Natia Qipshidze et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2012)

Add to Collection

Article Pharmacology & Pharmacy

Protein and DNA Oxidation in Different Anatomic Regions of Rat Brain in a Mimetic Ageing Model

Karolin Yanar et al.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2011)

Add to Collection

Article Pharmacology & Pharmacy

Hydrogen Sulfide in the Rostral Ventrolateral Medulla Inhibits Sympathetic Vasomotor Tone through ATP-Sensitive K+ Channels

Qi Guo et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2011)

Add to Collection

Article Physiology

Exercise training prevents the exaggerated exercise pressor reflex in rats with chronic heart failure

Han-Jun Wang et al.

JOURNAL OF APPLIED PHYSIOLOGY (2010)

Add to Collection

Review Neurosciences

The sympathetic control of blood pressure

PG Guyenet

NATURE REVIEWS NEUROSCIENCE (2006)

Add to Collection

Article Multidisciplinary Sciences

Suppression of aging in mice by the hormone Klotho

H Kurosu et al.

SCIENCE (2005)

Add to Collection

© Peeref 2019-2024. All rights reserved.