Journal
BIOMEDICINES
Volume 11, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/biomedicines11041027
Keywords
enteric nervous system; diabetes; gastroenteropathy; inflammation; cytokine; wireless motility capsule
Ask authors/readers for more resources
Gastroenteropathy, a complication of diabetes, is associated with damage to the enteric nervous system. Systemic inflammation and neuropathy have been reported, but associations with gastroenteropathy are less known. This study explored these associations in individuals with diabetes and found that certain cytokines were associated with gastric and colonic transit times. Inverse correlations between cytokines and symptoms were also observed. These findings suggest a potential interaction between inflammation and the enteric nervous system in diabetes, highlighting the possibility of using anti-inflammatory strategies in managing diabetic gastroenteropathy.
Gastroenteropathy is a common complication in diabetes associated with damages to the enteric nervous system. Systemic low-grade inflammation facilitates neurotoxicity, and associations with peripheral and autonomic neuropathy have been reported. However, less is known of associations with gastroenteropathy. To explore the area cross-sectionally, we included individuals with diabetes (type 1: 56, type 2: 100) and 21 healthy controls. Serum levels of interleukin (IL)-6, IL-8, IL-10, tumour necrosis factor (TNF)-alpha, and interferon (IFN)-gamma were measured by multiplex technology. Segmental gastrointestinal transit times were assessed by wireless motility capsule investigations. Symptoms of gastroparesis were rated on Gastroparesis Cardinal Symptom Index questionnaires. Compared to healthy, levels of TNF-alpha were decreased in type 1 diabetes and increased in type 2 diabetes, while colonic transit time was increased (all p < 0.05). In diabetes, associations between IL-8 and prolonged gastric emptying (odds ratio (OR) 1.07, p = 0.027) and between IL-10 and prolonged colonic transit (OR 29.99, p = 0.013) were seen. Inverse correlations between IL-6 and nausea/vomiting (rho = -0.19, p = 0.026) and bloating (rho = -0.29; p < 0.001) were found. These findings indicate a plausible interaction between inflammation and the enteric nervous system in diabetes, which raises the question of whether anti-inflammatory strategies could be applied in management of diabetic gastroenteropathy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available