HDL-Based Therapy: Vascular Protection at All Stages

It is known that lipid metabolism disorders are involved in a wide range of pathologies. These pathologies include cardiovascular, metabolic, neurodegenerative diseases, and even cancer. All these diseases lead to serious health consequences, which makes it impossible to ignore them. Unfortunately, these diseases most often have a complex pathogenesis, which makes it difficult to study them and, in particular, diagnose and treat them. HDL is an important part of lipid metabolism, performing many functions under normal conditions. One of such functions is the maintaining of the reverse cholesterol transport. These functions are also implicated in pathology development. Thus, HDL contributes to vascular protection, which has been demonstrated in various conditions: Alzheimer's disease, atherosclerosis, etc. Many studies have shown that serum levels of HDL cholesterol correlate negatively with CV risk. With these data, HDL-C is a promising therapeutic target. In this manuscript, we reviewed HDL-based therapeutic strategies that are currently being used or may be developed soon.

Automated summary

Lipid metabolism disorders are involved in various diseases, including cardiovascular, metabolic, neurodegenerative diseases, and cancer. HDL, an important component of lipid metabolism, plays a significant role in vascular protection. Many studies have shown that low levels of HDL cholesterol are associated with increased cardiovascular risk. Therefore, HDL-C is considered a promising therapeutic target. This review discusses current and potential HDL-based therapeutic strategies.