4.7 Editorial Material

Special Issue: Cancer Metastasis and Therapeutic Resistance

Related references

Note: Only part of the references are listed.
Review Pharmacology & Pharmacy

Cell plasticity, senescence, and quiescence in cancer stem cells: Biological and therapeutic implications

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Summary: Cancer stem cells (CSCs) play a crucial role in cancer progression, metastasis, relapse, and therapy resistance. They maintain their self-renewal capability and resist the tumor microenvironment and treatments through mechanisms such as cellular plasticity, senescence, and quiescence. Understanding these mechanisms is important for future therapeutic implications.

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Cisplatin Induces Senescent Lung Cancer Cell-Mediated Sternness Induction via GRP78/Akt-Dependent Mechanism

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Summary: This study revealed that cisplatin treatment can induce cellular senescence and promote stemness induction via the GRP78/Akt signal transduction pathway. The GRP78/MTJ1 complex and stemness markers are upregulated in senescent cells, suggesting that targeting the binding between these proteins or inhibiting GRP78 translocation could be a useful strategy for cancer therapy.

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Osteoblast Secretome Modulated by Abiraterone Treatment Affects Castration Resistant Prostate Cancer Cell Proliferation

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Summary: Abiraterone, a selective inhibitor of androgen biosynthesis, has been approved for the treatment of prostate cancer. This study provides evidence that abiraterone can inhibit prostate cancer cell proliferation through modulation of multiple osteoblast proliferative signals.

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Rhosin Suppressed Tumor Cell Metastasis through Inhibition of Rho/YAP Pathway and Expression of RHAMM and CXCR4 in Melanoma and Breast Cancer Cells

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Summary: The study revealed that inhibiting the RhoA/C-YAP pathway with rhosin can effectively suppress metastasis in melanoma and breast cancer cells, providing a potentially useful therapeutic approach for these patients. Actions of rhosin include inhibition of RhoA/C activation, suppression of RHAMM and CXCR4 expression, and modulation of YAP nuclear localization.

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Drug resistance and Cancer stem cells

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Summary: Therapy resistance is a significant challenge in treating cancer patients, with intrinsic and acquired factors contributing to the development of resistance. CSCs play a key role in therapy resistance, as they are inherently resistant to anticancer treatments and can easily adapt to changes in the tumor microenvironment.

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Anti-Tumor Functions of Prelatent Antithrombin on Glioblastoma Multiforme Cells

Julia Penas-Martinez et al.

Summary: Our study reveals the versatile anti-tumor properties of prelatent antithrombin on U-87 MG glioblastoma multiforme cells, inhibiting migration and invasion while having a lesser effect on proliferation. Prelatent antithrombin down-regulated the expression of VEGFA, pSTAT3, and pERK1/2 in U-87 MG cells.

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Shun-Wen Cheng et al.

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Core-Fucosylated Tetra-Antennary N-Glycan Containing A Single N-Acetyllactosamine Branch Is Associated with Poor Survival Outcome in Breast Cancer

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The Senescence-Stemness Alliance - A Cancer-Hijacked Regeneration Principle

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Antithrombin controls tumor migration, invasion and angiogenesis by inhibition of enteropeptidase

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