Correspondence between Aortic and Arterial Stiffness, and Diastolic Dysfunction in Apparently Healthy Female Patients with Post-Acute COVID-19 Syndrome

Article Medicine, General & Internal

Evaluation of Aortic Elasticity Parameters in Survivors of COVID-19 Using Echocardiography Imaging

Ugur Kucuk et al.

Summary: This study found that SARS-CoV-2 may cause impaired aortic elasticity parameters in COVID-19 survivors, which is associated with impaired arterial wall function.

MEDICAL PRINCIPLES AND PRACTICE (2022)

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Article Physiology

Carotid stiffness, intima-media thickness and aortic augmentation index among adults with SARS-CoV-2

Rachel E. Szeghy et al.

Summary: The study revealed that young adults who tested positive for SARS-CoV-2 showed higher carotid artery stiffness, Young's modulus, and aortic augmentation index compared to healthy young adults, suggesting potential detrimental effects on cardiovascular health.

EXPERIMENTAL PHYSIOLOGY (2022)

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Review Cell Biology

COVID-19 and the Vasculature: Current Aspects and Long-Term Consequences

Berenice Martinez-Salazar et al.

Summary: This review summarizes the impact of SARS-CoV-2 infection on the vasculature, including its promotion of vascular inflammation and its relationship with cardiovascular diseases and endothelial changes. The potential long-term consequences of COVID-19 are also discussed.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Article Health Care Sciences & Services

Evolution of Echocardiographic Abnormalities Identified in Previously Healthy Individuals Recovering from COVID-19

Cristina Tudoran et al.

Summary: This study assessed various cardiac abnormalities in post-acute COVID-19 syndrome patients using transthoracic echocardiography (TTE). The findings showed that most of the TTE abnormalities alleviated during the follow-up period, but some abnormalities, especially diastolic dysfunction (DD), may persist, raising concerns about chronic alterations.

JOURNAL OF PERSONALIZED MEDICINE (2022)

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Article Cardiac & Cardiovascular Systems

Vascular Dysfunction of COVID-19 Is Partially Reverted in the Long-Term

Luca Zanoli et al.

Summary: COVID-19 has mid- and long-term effects on vascular and cardiac autonomic function, with increased aortic pulse wave velocity and improved arterial stiffness.

CIRCULATION RESEARCH (2022)

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Article Physiology

Six-month longitudinal tracking of arterial stiffness and blood pressure in young adults following SARS-CoV-2 infection

Rachel E. Szeghy et al.

Summary: This study aimed to investigate the potential long-lasting effects of SARS-CoV-2 infection on markers of arterial stiffness among young adults for 6 months following infection. Carotid femoral pulse wave velocity was significantly reduced while carotid stiffness measures remained unaltered over the 6-month period. These findings suggest several months of recovery from infection may be necessary for young adults to improve various markers of arterial stiffness, possibly contributing to cardiovascular health and recovery among those infected with SARS-CoV-2.

JOURNAL OF APPLIED PHYSIOLOGY (2022)

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Review Biology

Acute and Long-Term Consequences of COVID-19 on Arterial Stiffness-A Narrative Review

Ioana Madalina Zota et al.

Summary: COVID-19 is a complex multisystemic disease with extensive cardiovascular involvement. Emerging evidence shows that the endothelium plays multiple roles in COVID-19 physiopathology. COVID-19 causes early vascular aging and arterial stiffness. Long-term follow-up studies are needed to investigate the reversibility of COVID-19-induced vascular changes and their associated prognostic implications.

LIFE-BASEL (2022)

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Article Multidisciplinary Sciences

Are lipid ratios and triglyceride-glucose index associated with critical care outcomes in COVID-19 patients?

Marzieh Rohani-Rasaf et al.

Summary: Lipid ratios and the TyG index are associated with the severity and mortality of COVID-19. Patients with higher lipid ratios and TyG index are more likely to have severe symptoms and higher risk of death.

PLOS ONE (2022)

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Article Public, Environmental & Occupational Health

Association of triglyceride-glucose index with prognosis of COVID-19: A population-based study

Yoonkyung Chang et al.

Summary: The TyG index, a surrogate marker for insulin resistance, is associated with an increased risk of severe complications in COVID-19 infected patients.

JOURNAL OF INFECTION AND PUBLIC HEALTH (2022)

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Article Biochemistry & Molecular Biology

The Impact of Metabolic Syndrome and Obesity on the Evolution of Diastolic Dysfunction in Apparently Healthy Patients Suffering from Post-COVID-19 Syndrome

Cristina Tudoran et al.

Summary: This study analyzed the evolution of diastolic dysfunction (DD) in individuals with post-COVID-19 syndrome. The results showed that DD was commonly diagnosed in patients with obesity and metabolic syndrome (MS), but there was also a significant prevalence in non-obese individuals. The severity of DD gradually decreased, especially in patients without MS.

BIOMEDICINES (2022)

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Letter Cardiac & Cardiovascular Systems

Endothelial dysfunction in convalescent COVID-19 patients: Systematic review and meta-analysis

Panagiotis Theofilis et al.

ARCHIVES OF CARDIOVASCULAR DISEASES (2022)

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Article Medicine, General & Internal

Clinical assessment of endothelial function in convalescent COVID-19 patients: a meta-analysis with meta-regressions

Pasquale Ambrosino et al.

Summary: Impaired endothelial function can be documented in convalescent COVID-19 patients, especially when residual clinical manifestations persist. Targeting endothelial dysfunction through pharmacological and rehabilitation strategies may represent an attractive therapeutic option.

ANNALS OF MEDICINE (2022)

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Article Peripheral Vascular Disease

Vascular Dysfunction and Its Cardiovascular Consequences During and After COVID-19 Infection: A Narrative Review

Manisha Kar

Summary: The COVID-19 pandemic caused by the SARS-CoV2 virus has led to significant morbidity and mortality globally, with a particular impact on the cardiovascular system and vascular homeostasis. Post-COVID complications, such as endothelial dysfunction and arterial stiffness, can persist for weeks to months following infection, contributing to increased health risks for patients. The disease's pathophysiology involves a complex interplay between the virus's impact on endothelial cells, the renin-angiotensin-aldosterone system, and the kallikrein kinin system, resulting in derangements in vascular function.

VASCULAR HEALTH AND RISK MANAGEMENT (2022)

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Review Nutrition & Dietetics

Visceral adiposity, subcutaneous adiposity, and severe coronavirus disease-2019 (COVID-19): Systematic review and meta-analysis

Raymond Pranata et al.

Summary: Visceral adiposity was associated with increased severity of COVID-19, while subcutaneous adiposity was not significantly different. This indicates the importance of visceral fat as a potential indicator for severe COVID-19 outcomes.

CLINICAL NUTRITION ESPEN (2021)

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Article Cardiac & Cardiovascular Systems

The Triglyceride-Glucose Index, an Insulin Resistance Marker, Was Non-linear Associated With All-Cause and Cardiovascular Mortality in the General Population

Xiao-cong Liu et al.

Summary: The study found a non-linear relationship between TyG index and the risk of all-cause and cardiovascular disease mortality, with threshold values of 9.36 and 9.52. Above these threshold points, TyG index was significantly associated with an increased risk of mortality.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

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Article Medicine, General & Internal

Arterial stiffness in acute COVID-19 and potential associations with clinical outcome

S. Schnaubelt et al.

Summary: COVID-19 appears to be associated with increased arterial stiffness as reflected by higher pulse wave velocities. Higher pulse wave velocity may be related to longer hospital stay and increased mortality, particularly in non-survivors.

JOURNAL OF INTERNAL MEDICINE (2021)

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Article Multidisciplinary Sciences

Estimated pulse wave velocity improves risk stratification for all-cause mortality in patients with COVID-19

Kimon Stamatelopoulos et al.

Summary: Accurate risk stratification is crucial in guiding therapeutic strategies for COVID-19 patients. This study found that estimated pulse wave velocity (ePWV), a marker of arterial stiffness, provided additional prognostic value beyond established risk factors and scores in risk stratification of hospitalized COVID-19 patients. The optimal prognostic ePWV value was 13.0 m/s, suggesting its potential as a clinical tool for refining risk stratification in these patients.

SCIENTIFIC REPORTS (2021)

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Article Medicine, General & Internal

COVID-19 and cardiovascular complications - preliminary results of the LATE-COVID study

Joanna Lewek et al.

Summary: Post-COVID-19 cardiovascular complications typically appear 1-4 months after disease recovery, with severe complications observed in 27.5% of hospitalized patients. Compared to those with mild complications, patients with severe complications are more likely to have diabetes, decreased ejection fraction, higher levels of CRP and troponin, as well as experiencing dyspnoea and exercise intolerance more frequently.

ARCHIVES OF MEDICAL SCIENCE (2021)

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Review Endocrinology & Metabolism

COVID-19 and metabolic disease: mechanisms and clinical management

Charlotte Steenblock et al.

Summary: Up to 50% of COVID-19 fatalities are associated with metabolic and vascular disorders. COVID-19 has direct links with the metabolic and endocrine systems, increasing the risk and severity of the disease in patients with metabolic dysfunction such as obesity, hypertension, non-alcoholic fatty liver disease, and diabetes.

LANCET DIABETES & ENDOCRINOLOGY (2021)

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Review Endocrinology & Metabolism

Metabolic dysfunction and immunometabolism in COVID-19 pathophysiology and therapeutics

Rachael Batabyal et al.

Summary: Patients with underlying metabolic dysfunction, such as type 2 diabetes mellitus and obesity, are at a higher risk for COVID-19 complications due to the deranged immune response and cellular energy deprivation, which can lead to multi-organ dysfunction. Novel therapeutic approaches targeting both immune and metabolic pathways, using repurposed drugs or newly developed molecules, show promising results for efficacious treatment of COVID-19 in patients with underlying metabolic conditions.

INTERNATIONAL JOURNAL OF OBESITY (2021)

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Editorial Material Peripheral Vascular Disease

Arterial stiffness and COVID-19: A bidirectional cause-effect relationship

Sahrai Saeed et al.

JOURNAL OF CLINICAL HYPERTENSION (2021)

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Article Health Care Sciences & Services

Alterations of Left Ventricular Function Persisting during Post-Acute COVID-19 in Subjects without Previously Diagnosed Cardiovascular Pathology

Mariana Tudoran et al.

Summary: This study found that some COVID-19 patients without a history of cardiovascular diseases still experienced alterations in left ventricular systolic function and diastolic dysfunction in the weeks following discharge. These changes may be linked to elevated myocardial necrosis markers during the acute phase of the illness.

JOURNAL OF PERSONALIZED MEDICINE (2021)

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Letter Cardiac & Cardiovascular Systems

Vascular complications from SARS-CoV2: a unique finding or a common feature of viral infections?

Igor Vaz

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2021)

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Editorial Material Endocrinology & Metabolism

COVID-19 editorial: mechanistic links and therapeutic challenges for metabolic diseases one year into the COVID-19 pandemic

Christopher M. Tessier et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2021)

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Article Multidisciplinary Sciences

Age-adjusted cut-off values of lipid accumulation product (LAP) for predicting hypertension

Anastasiya M. Kaneva et al.

Summary: The study found that in healthy subjects, the values of lipid accumulation product (LAP) increased with age, while the values did not vary with age in patients with hypertension. Therefore, age-adjusted cut-off values of LAP should be used in diagnosing hypertension to accurately assess the risk.

SCIENTIFIC REPORTS (2021)

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Article Medicine, General & Internal

A Multidisciplinary Approach to Evaluate the Presence of Hepatic and Cardiac Abnormalities in Patients with Post-Acute COVID-19 Syndrome-A Pilot Study

Felix Bende et al.

Summary: The study found that post-acute COVID-19 syndrome may be associated with residual cardiac and hepatic lesions, particularly in more severe cases, putting these patients at risk of developing liver fibrosis and cardiac alterations.

JOURNAL OF CLINICAL MEDICINE (2021)

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Article Peripheral Vascular Disease

Covid-19 Effects on ARTErial StIffness and Vascular AgeiNg: CARTESIAN Study Rationale and Protocol

Rosa Maria Bruno et al.

Summary: The COVID-19 pandemic has led to the launch of the CARTESIAN study, the first international multicenter study into the effects of COVID-19 on non-invasive biomarkers of vascular aging. The study aims to evaluate early vascular aging (EVA) and its relationship with COVID-19 severity, psychosocial factors, comorbidities, and chronic treatments. With participation from 43 centers in 21 countries, the study is expected to provide valuable insights into the impact of COVID-19 on vascular health.

ARTERY RESEARCH (2021)

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Editorial Material Cardiac & Cardiovascular Systems