4.7 Review

The Impact of Smoking on Microbiota: A Narrative Review

Related references

Note: Only part of the references are listed.
Article Geriatrics & Gerontology

The Red and Orange Complex Subgingival Microbiome of Cognitive Impairment and Cognitively Normal Elderly with Periodontitis

Fatimah Maria Tadjoedin et al.

Summary: This study aimed to evaluate the subgingival microbiome in elderly Indonesian subjects with periodontitis and cognitive impairment. The findings showed differences in the subgingival microbiota between the cognitively impaired and cognitively normal groups, with a higher abundance of Porphyromonas and Treponema bacteria in the cognitive impairment group. These results suggest a potential link between subgingival microbiota and cognitive impairment, highlighting the need for further investigation into the pathogenesis of cognitive impairment.

GERIATRICS (2022)

Article Medicine, General & Internal

Influence of cigarette smoking on oral microbiota in patients with recurrent aphthous stomatitis

Xue Wang et al.

Summary: The study found that patients with RAS have lower bacterial community diversity compared to non-smokers. The microbial community in smoking-associated RAS is less diverse and distinct from that of non-smokers, with higher abundance of Veillonella, Rothia, and Sneathia and lower abundance of certain genera. Smoking is closely related to changes in the oral microbiota among RAS patients, potentially impacting the pathogenesis of the disease.

JOURNAL OF INVESTIGATIVE MEDICINE (2022)

Article Allergy

Allergic rhinitis, microbiota and passive smoke in children: A pilot study

Giulia Brindisi et al.

Summary: This study evaluated the influence of passive smoke exposure and cotinine levels on nasal obstruction and microbial composition in children with allergic rhinitis. The results showed that passive smoke exposure led to decreased nasal flow and changes in microbial composition, while cotinine levels were associated with specific bacterial taxa abundance and nasal flow.

PEDIATRIC ALLERGY AND IMMUNOLOGY (2022)

Article Multidisciplinary Sciences

Supragingival microbiome alternations as a consequence of smoking different tobacco types and its relation to dental caries

Farah Al-Marzooq et al.

Summary: This study assessed the impact of smoking different tobacco types on the supragingival microbiome and its association with dental caries. The findings revealed significant alterations in the supragingival microbiota among smokers of various tobacco types. Cigarette smokers had a higher prevalence of cariogenic bacteria, while Medwakh smokers had elevated levels of periodontopathogens. The study highlights the importance of smoking in shaping the supragingival microbiome and emphasizes the need for further research on its consequences for oral health.

SCIENTIFIC REPORTS (2022)

Article Biochemistry & Molecular Biology

Cigarette Smoking and Human Gut Microbiota in Healthy Adults: A Systematic Review

Martina Antinozzi et al.

Summary: This systematic review analyzes the relationship between smoking and the composition of gut microbiota in healthy adults. The findings suggest that smoking leads to reduced bacterial species diversity and variability indices, but the results regarding bacterial abundance are mixed.

BIOMEDICINES (2022)

Review Biochemistry & Molecular Biology

Gut Microbiota and Autoimmune Diseases: A Charming Real World Together with Probiotics

Andrea Piccioni et al.

Summary: This review reports the effects of probiotics administration in the most common autoimmune disease and inflammatory immune-mediated diseases. Studies suggest that probiotics may help restore gut eubiosis, thus affecting the pathogenesis and course of these diseases. Despite limited and sometimes contradictory research data, physicians should consider using probiotics as supportive measures in the treatment of patients with these diseases.

CURRENT MEDICINAL CHEMISTRY (2022)

Review Biochemistry & Molecular Biology

Microbiome in Critical Care: An Unconventional and Unknown Ally

Christian Zanza et al.

Summary: This article reviews the role of the microbiota in the development of sepsis in ICU patients and provides the latest research updates. Hospitalization and intensive care in ICU can alter the intestinal microbiota, leading to dysbiosis and serious complications. The microbiota also plays a significant role in the severity of SARS-CoV-2 infection and the development of intestinal complications. By preserving the integrity of the microbiota, interventions like probiotics, synbiotics, and fecal microbiota transplantation can help maintain homeostasis and prevent ICU-associated complications.

CURRENT MEDICINAL CHEMISTRY (2022)

Review Biochemistry & Molecular Biology

Chronic Systemic Low-Grade Inflammation and Modern Lifestyle: The Dark Role of Gut Microbiota on Related Diseases with a Focus on COVID-19 Pandemic

Tiziana Mundula et al.

Summary: Chronic systemic low-grade inflammation (CSLGI) is a long-term condition that causes damage to organs and tissues and is a major risk factor for chronic diseases. Currently, there is a high global incidence of chronic inflammatory diseases, often related to changes in lifestyle. Lifestyle factors such as diet, stress, smoking, alcohol abuse, physical inactivity, and indoor living and working have an impact on the composition and function of the gut microbiota, which plays a crucial role in CSLGI.

CURRENT MEDICINAL CHEMISTRY (2022)

Review Obstetrics & Gynecology

The Interplay between Androgen and Gut Microbiota: Is There a Microbiota-Gut-Testis Axis

Xiangping Li et al.

Summary: This article reviews the impact of gut microbiota on the host, especially the importance in androgen production and metabolism, as well as the regulation of the reproductive system, and proposes the interaction between microbiota and testis. The research also discusses the relationship between gut microbiota and male health conditions, as well as gender-related diseases.

REPRODUCTIVE SCIENCES (2022)

Article Food Science & Technology

The regulatory effect of fermented black barley on the gut microbiota and metabolic dysbiosis in mice exposed to cigarette smoke

Lingyue Zhong et al.

Summary: This study investigated the protective effects of fermented black barley on cigarette smoke induced damage. The results showed that fermented black barley can alleviate lung and reproductive organ injury, improve sperm motility and antioxidative capacity of the lung. Furthermore, it can also regulate intestinal microbiome diversity and metabolic dysbiosis induced by cigarette smoking.

FOOD RESEARCH INTERNATIONAL (2022)

Review Pharmacology & Pharmacy

Human matters in asthma: Considering the microbiome in pulmonary health

Sandesh J. Marathe et al.

Summary: Microbial communities within humans play a crucial role in health and well-being, and understanding the contribution of the airway microbiome in asthma pathogenesis is of great importance in developing new treatments and optimizing existing therapies.

FRONTIERS IN PHARMACOLOGY (2022)

Article Pharmacology & Pharmacy

Crosstalk between gut microbiota and lung inflammation in murine toxicity models of respiratory exposure or co-exposure to carbon nanotube particles and cigarette smoke extract

Sukanta S. Bhattacharya et al.

Summary: This study found that inhaled carbon nanotubes (CNTs) may cause abnormalities in gut microbiota, and the changes in gut microbiota may play a role in modulating CNT-induced lung immunotoxicity. Co-exposure to tobacco smoke may also modulate the effects of CNTs. Lung exposure to CNTs, cigarette smoke extract (CSE), and their combination induced different effects on gut microbiome, suggesting communication between the lungs and the gut. The study also provided evidence of bidirectional gut-lung crosstalk modulating CNT-induced lung immunotoxicity.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2022)

Review Biochemistry & Molecular Biology

Gut Microbiota and Clostridium difficile: What We Know and the New Frontiers

Andrea Piccioni et al.

Summary: The composition of the human microbiome plays a crucial role in health, and alterations in the microbiota can lead to Clostridium difficile infection.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Biochemistry & Molecular Biology

Health effects associated with smoking: a Burden of Proof study

Xiaochen Dai et al.

Summary: Smoking is a major public health challenge and this study provides comprehensive and up-to-date estimates of the dose-response relationship between smoking and various health outcomes. The findings highlight the strong association between smoking and certain health conditions, providing important information for tobacco control advocates, policy makers, researchers, physicians, smokers, and the general public.

NATURE MEDICINE (2022)

Article Gastroenterology & Hepatology

Cigarette smoke promotes colorectal cancer through modulation of gut microbiota and related metabolites

Xiaowu Bai et al.

Summary: Cigarette smoke exposure alters the gut microbiota and related metabolites, leading to an increased risk of colorectal cancer. Mice exposed to cigarette smoke had dysbiosis of the gut microbiota, increased bile acid metabolites, activated oncogenic signaling pathways, and impaired gut barrier function.
Article Nursing

Environmental Tobacco Smoke Exposure and Breastfeeding Duration Influence the Composition and Dynamics of Gut Microbiota in Young Children Aged 0-2 Years

Tianqu Xie et al.

Summary: Prolonged breastfeeding and reduced smoke exposure are beneficial to the diversity and composition of gut microbiota in young children.

BIOLOGICAL RESEARCH FOR NURSING (2021)

Review Biochemistry & Molecular Biology

Role of the gut microbiota in airway immunity and host defense against respiratory infections

Maike Willers et al.

Summary: Colonization of the intestine with commensal bacteria is essential for maintaining human health and can impact airway immunity and host defense against respiratory infections. Specific compositions and functions of gut commensal microbiota can provide protection against respiratory infections caused by bacterial and viral pathogens. Understanding these relationships can help in modulating gut microbiome maturation to enhance lifelong resistance to respiratory infections.

BIOLOGICAL CHEMISTRY (2021)

Review Gastroenterology & Hepatology

The Microbiota-Gut-Brain Axis: From Motility to Mood

Kara G. Margolis et al.

Summary: The gut-brain axis is crucial in maintaining homeostasis, with the microbiome playing a significant role in modulating signaling along this axis. This axis impacts disorders like irritable bowel syndrome and mood disorders, with serotonin being a key neurotransmitter involved in these conditions. More research is needed before these findings can be applied for diagnostic and therapeutic purposes in patient populations.

GASTROENTEROLOGY (2021)

Review Biotechnology & Applied Microbiology

Relationships among smoking, oxidative stress, inflammation, macromolecular damage, and cancer

Andrew W. Caliri et al.

Summary: Smoking is a major risk factor for various diseases due to the reactive oxygen-and nitrogen species present in tobacco smoke. This oxidative stress can lead to inflammation and cancer initiation or progression through macromolecular damage. Repair mechanisms and antioxidant defense pathways play a role in combating smoking-induced oxidative stress and its consequences.

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH (2021)

Article Microbiology

Disruptions in oral and nasal microbiota in biomass and tobacco smoke associated chronic obstructive pulmonary disease

Dhiraj M. Agarwal et al.

Summary: Chronic exposures to tobacco and biomass smoke are common risk factors for COPD development. The study compared nasal and oral microbiota in healthy individuals, TSCOPD, and BMSCOPD patients, finding differences in microbial abundance, particularly in genera such as Actinomyces and Corynebacterium among COPD subjects. This suggests that dysbiosis in microbial communities may contribute to disease progression and highlights the importance of identifying etiological agents for disease manifestation.

ARCHIVES OF MICROBIOLOGY (2021)

Article Multidisciplinary Sciences

Gut microbiota modulates weight gain in mice after discontinued smoke exposure

Leviel Fluhr et al.

Summary: Smoking and cessation induce a dysbiotic state in the intestines, leading to weight gain. Depletion of gut microbiota induced by antibiotics prevents weight gain after smoking cessation.

NATURE (2021)

Article Pharmacology & Pharmacy

Cigarette smoking exposure breaks the homeostasis of cholesterol and bile acid metabolism and induces gut microbiota dysbiosis in mice with different diets

Yanhong Yang et al.

Summary: The study found that exposure to cigarette smoking can disrupt liver cholesterol metabolism, imbalance bile acids, and alter the composition of gut microbiota. This highlights the importance of smoking bans for public health.

TOXICOLOGY (2021)

Article Immunology

Active Smoking Induces Aberrations in Digestive Tract Microbiota of Rats

Xiang Wang et al.

Summary: This study found that active smoking can lead to hyperglycemia, decreased serum insulin and leptin levels, and induced changes in microbiota structure, composition, and metabolic function along the digestive tract. Active smoking may pose an overlooked health risk through its potential effects on the gut microbiota, which are associated with various chronic diseases.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

Review Medicine, General & Internal

Microbiota in Pancreatic Diseases: A Review of the Literature

Tommaso Schepis et al.

Summary: The gut microbiota plays a crucial role in the development of pancreatic diseases and can be a potential target for therapeutic interventions. Understanding the interaction between gut microbiota and the pancreas is important for the management of these diseases. Modifying the intestinal bacterial flora could have significant therapeutic implications for pancreatic diseases.

JOURNAL OF CLINICAL MEDICINE (2021)

Article Cardiac & Cardiovascular Systems

Impacts of Cigarette Smoking Status on Metabolomic and Gut Microbiota Profile in Male Patients With Coronary Artery Disease: A Multi-Omics Study

Xiaomin Hu et al.

Summary: The study found that smoking can impact the gut microbiota composition and serum metabolites of patients with coronary artery disease, showing differences compared to non-smokers. Multi-omics analysis revealed that specific changes in bacterial taxa may be associated with disease severity or outcomes by mediating metabolites.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

Review Immunology

Role and Mechanism of Gut Microbiota in Human Disease

Yinwei Chen et al.

Summary: The human gut microbiome plays a crucial role in human health, and dysbiosis may lead to various chronic diseases. The mechanisms of its impact on neurodegenerative diseases, cardiovascular diseases, metabolic diseases, and gastrointestinal diseases are extremely complex.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

Article Biochemistry & Molecular Biology

Exposure to a mixture of cigarette smoke carcinogens disturbs gut microbiota and influences metabolic homeostasis in A/J mice

Zhuo Qu et al.

Summary: Exposure to the mixture of NNK plus BaP was found to trigger lung carcinogenesis and alter fecal bacterial composition. Furthermore, metabolomics analysis showed regulation in various metabolic pathways including purine metabolism, phenylalanine metabolism, and primary bile acid biosynthesis.

CHEMICO-BIOLOGICAL INTERACTIONS (2021)

Article Immunology

Effects of Smoking on Inflammatory Markers in a Healthy Population as Analyzed via the Gut Microbiota

Su Yan et al.

Summary: Smoking significantly alters gut microbiota composition, leading to increased intestinal inflammation. Compared to non-smokers, smokers have distinct gut microbiota profiles, with higher levels of proinflammatory bacteria and lower levels of anti-inflammatory microorganisms.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

Article Immunology

Association Between Oral Microbiota and Cigarette Smoking in the Chinese Population

Yi-Jing Jia et al.

Summary: Cigarette smoking has been shown to alter the composition of oral microbiota, potentially impacting oral health. Additionally, the study revealed differences in oral microbiota diversity between smokers and non-smokers in the Chinese population.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

Review Physiology

Effect of Cigarette Smoke on Gut Microbiota: State of Knowledge

Xiaohua Gui et al.

Summary: Cigarette smoke is a major source of toxic chemical exposures to humans, affecting both neuronal and immune-inflammatory systems. Smoking is a risk factor for intestinal disorders, such as Crohn's disease and peptic ulcer, while also being protective against ulcerative colitis. The mechanisms linking cigarette smoking with intestinal microbiota dysbiosis is not fully understood, but may involve various components in cigarette smoke and interactions between different body systems.

FRONTIERS IN PHYSIOLOGY (2021)

Article Medicine, General & Internal

Airway microbial communities, smoking and asthma in a general population sample

Elena M. Turek et al.

Summary: This study investigated airway bacterial communities in Australian adults, revealing smoking-associated diversity loss and significant abnormalities in microbiota structure, while asthmatic microbiota were selectively affected. The study demonstrated that healthy airway microbiota form a highly structured ecosystem.

EBIOMEDICINE (2021)

Article Microbiology

Cigarette Smoking and Opium Use in Relation to the Oral Microbiota in Iran

Zeni Wu et al.

Summary: This study examined the association between cigarette and opium use with the oral microbiota. The results showed that cigarette and opium use was linked to alterations in the diversity, composition, and presence of certain taxa in the oral microbial community.

MICROBIOLOGY SPECTRUM (2021)

Article Oncology

The effects of smoking and drinking on the oral and esophageal microbiota of healthy people

Zhengqi Li et al.

Summary: This study investigated the effects of smoking and drinking on the microbiota in the saliva and esophagus of healthy individuals. The results showed differences in the microbial communities in the saliva of smoking and drinking individuals compared to non-smokers and non-drinkers, but no significant variances in the esophagus along the upper, middle, and lower segments.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

Review Biochemistry & Molecular Biology

Microbiota and Myopericarditis: The New Frontier in the Car-Diological Field to Prevent or Treat Inflammatory Cardiomyo-Pathies in COVID-19 Outbreak

Andrea Piccioni et al.

Summary: Myopericarditis is an inflammatory heart condition involving the pericardium and myocardium, which can lead to various complications. Its pathogenesis may be related to viral infections, bacterial infections, toxic substances, and immune mediated disorders. Some research has shown the contribution of gut microbiota and its metabolites to cardiac inflammation and disease progression.

BIOMEDICINES (2021)

Article Dentistry, Oral Surgery & Medicine

Subgingival Microbiota Profile in Association with Cigarette Smoking in Young Adults: A Cross-Sectional Study

Kresimir Basic et al.

Summary: This study aimed to investigate the prevalence of subgingival bacteria in young smokers and non-smokers without clinical signs of periodontal disease. It was found that smokers had a significantly higher prevalence of Actinomyces odontolyticus and a significantly lower prevalence of Streptococcus sanguinis compared to non-smokers. Smoking affects the composition of subgingival microbiota, either through depletion of beneficial bacteria or an increase in pathogenic bacteria.

DENTISTRY JOURNAL (2021)

Review Medicine, General & Internal

The Upper Airway Microbiota, Environmental Exposures, Inflammation, and Disease

Ziyad Elgamal et al.

Summary: The microbiota of the upper airways plays a crucial role in maintaining homeostasis and is impacted by environmental pollution, inflammation, and disease. The composition of the microbiota is associated with airborne exposures, diseases, and inflammatory conditions, influencing normal respiratory development and function.

MEDICINA-LITHUANIA (2021)

Review Biochemistry & Molecular Biology

Airway Microbiota as a Modulator of Lung Cancer

Taichiro Goto

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Biochemistry & Molecular Biology

Gene Therapy for Cystic Fibrosis: Progress and Challenges of Genome Editing

Giulia Maule et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Nutrition & Dietetics

Gut Microbiota in Hypertension and Atherosclerosis: A Review

Barbara J. H. Verhaar et al.

NUTRIENTS (2020)

Article Medicine, Research & Experimental

Revealing oral microbiota composition and functionality associated with heavy cigarette smoking

Mohammad Tahseen Al Bataineh et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

Review Immunology

Microbes, metabolites, and the gut-lung axis

Anh Thu Dang et al.

MUCOSAL IMMUNOLOGY (2019)

Review Substance Abuse

The effect of smoking on caries-erelated microorganisms

Jiayi Wu et al.

TOBACCO INDUCED DISEASES (2019)

Review Medicine, Research & Experimental

Smoking and microbiome in oral, airway, gut and some systemic diseases

Chunrong Huang et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2019)

Review Pediatrics

Lower Airway Microbiota

Giulio Pulvirenti et al.

FRONTIERS IN PEDIATRICS (2019)

Article Multidisciplinary Sciences

The upper-airway microbiota and loss of asthma control among asthmatic children

Yanjiao Zhou et al.

NATURE COMMUNICATIONS (2019)

Article Critical Care Medicine

Lung Microbiota Is Related to Smoking Status and to Development of Acute Respiratory Distress Syndrome in Critically Ill Trauma Patients

Ariane R. Panzer et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2018)

Article Medicine, General & Internal

Association between Cigarette Smoking Status and Composition of Gut Microbiota: Population-Based Cross-Sectional Study

Su Hwan Lee et al.

JOURNAL OF CLINICAL MEDICINE (2018)

Article Microbiology

The effect of cigarette smoking on the oral and nasal microbiota

Guoqin Yu et al.

MICROBIOME (2017)

Article Respiratory System

Risk factors for lung cancer worldwide

Jyoti Malhotra et al.

EUROPEAN RESPIRATORY JOURNAL (2016)

Article Multidisciplinary Sciences

Analysis of the association between host genetics, smoking, and sputum microbiota in healthy humans

Mi Young Lim et al.

SCIENTIFIC REPORTS (2016)

Editorial Material Immunology

Airway microbiota and acute respiratory infection in children

Kohei Hasegawa et al.

EXPERT REVIEW OF CLINICAL IMMUNOLOGY (2015)

Review Gastroenterology & Hepatology

Epidemiology and risk factors for IBD

Ashwin N. Ananthakrishnan

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2015)

Review Otorhinolaryngology

Asthma risk factors

Elina Toskala et al.

INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY (2015)

Article Microbiology

Oral cavity contains distinct niches with dynamic microbial communities

Xin Xu et al.

ENVIRONMENTAL MICROBIOLOGY (2015)

Article Infectious Diseases

Association between cigarette smoking and the vaginal microbiota: a pilot study

Rebecca M. Brotman et al.

BMC INFECTIOUS DISEASES (2014)

Article Gastroenterology & Hepatology

Smoking Cessation Alters Intestinal Microbiota: Insights from Quantitative Investigations on Human Fecal Samples Using FISH

Luc Biedermann et al.

INFLAMMATORY BOWEL DISEASES (2014)

Article Critical Care Medicine

Comparison of the Respiratory Microbiome in Healthy Nonsmokers and Smokers

Alison Morris et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2013)

Article Microbiology

The Human Oral Microbiome

Floyd E. Dewhirst et al.

JOURNAL OF BACTERIOLOGY (2010)

Article Multidisciplinary Sciences

Disordered Microbial Communities in Asthmatic Airways

Markus Hilty et al.

PLOS ONE (2010)

Article Multidisciplinary Sciences

Disordered Microbial Communities in the Upper Respiratory Tract of Cigarette Smokers

Emily S. Charlson et al.

PLOS ONE (2010)

Article Dentistry, Oral Surgery & Medicine

Effects of periodontitis and smoking on the microbiota of oral mucous membranes and saliva in systemically healthy subjects

DL Mager et al.

JOURNAL OF CLINICAL PERIODONTOLOGY (2003)

Article Dentistry, Oral Surgery & Medicine

Relationship of cigarette smoking to the subgingival microbiota

AD Haffajee et al.

JOURNAL OF CLINICAL PERIODONTOLOGY (2001)