The Emergence of TRP Channels Interactome as a Potential Therapeutic Target in Pancreatic Ductal Adenocarcinoma

Integral membrane proteins, known as Transient Receptor Potential (TRP) channels, are cellular sensors for various physical and chemical stimuli in the nervous system, respiratory airways, colon, pancreas, bladder, skin, cardiovascular system, and eyes. TRP channels with nine subfamilies are classified by sequence similarity, resulting in this superfamily's tremendous physiological functional diversity. Pancreatic Ductal Adenocarcinoma (PDAC) is the most common and aggressive form of pancreatic cancer. Moreover, the development of effective treatment methods for pancreatic cancer has been hindered by the lack of understanding of the pathogenesis, partly due to the difficulty in studying human tissue samples. However, scientific research on this topic has witnessed steady development in the past few years in understanding the molecular mechanisms that underlie TRP channel disturbance. This brief review summarizes current knowledge of the molecular role of TRP channels in the development and progression of pancreatic ductal carcinoma to identify potential therapeutic interventions.

Automated summary

Integral membrane proteins, called TRP channels, act as cellular sensors in various systems, and their sequence similarity classifies them into nine subfamilies, providing a wide range of physiological functions. Pancreatic Ductal Adenocarcinoma (PDAC) is a highly aggressive form of pancreatic cancer. Despite the difficulty in studying human tissue samples, recent research has made progress in understanding the molecular mechanisms of TRP channel disturbance. This review summarizes the current understanding of TRP channels' role in the development and progression of pancreatic ductal carcinoma, aiming to identify potential therapeutic interventions.