4.7 Review

Overcoming EGFR Resistance in Metastatic Colorectal Cancer Using Vitamin C: A Review

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

The Role of Anti-EGFR Monoclonal Antibody in mCRC Maintenance Therapy

Meiqin Yuan et al.

Summary: Currently, the combination of anti-EGFR mAb and chemotherapy is the first-line treatment standard for RAS wild-type mCRC. However, there is ongoing debate regarding the use of anti-EGFR mAb for maintenance treatment after the initial treatment. Despite the lack of evidence from large-scale clinical trials, more studies support the use of anti-EGFR mAb for maintenance therapy, although cost and drug resistance remain concerns.

FRONTIERS IN MOLECULAR BIOSCIENCES (2022)

Article Biochemistry & Molecular Biology

Circulating tumor DNA to guide rechallenge with panitumumab in metastatic colorectal cancer: the phase 2 CHRONOS trial

Andrea Sartore-Bianchi et al.

Summary: This study aimed to use blood-based testing of RAS/BRAF/EGFR mutation levels to guide anti-EGFR therapy in patients with colorectal cancer. The results showed that rechallenge therapy with panitumumab, guided by liquid biopsies, had favorable outcomes compared to standard treatments. This suggests that liquid biopsies can effectively and safely guide treatment decisions in patients with mCRC.

NATURE MEDICINE (2022)

Review Oncology

Liquid Biopsy: A Distinctive Approach to the Diagnosis and Prognosis of Cancer

Tetsuyuki Hirahata et al.

Summary: Liquid biopsy is a simple, fast, and valuable technique that analyzes circulating tumor DNA, circulating tumor cells, and other tumor-derived material in the blood to provide a new approach for early cancer diagnosis and prognosis. Compared to tissue biopsy, liquid biopsy has advantages such as lower cost, non-invasiveness, and easier sample collection.

CANCER INFORMATICS (2022)

Review Oncology

Resistance to anti-EGFR therapies in metastatic colorectal cancer: underlying mechanisms and reversal strategies

Jing Zhou et al.

Summary: The article discusses the resistance mechanisms to anti-EGFR monoclonal antibodies, as well as diverse approaches to reverse resistance to this therapy.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

Review Oncology

High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer

Franziska Bottger et al.

Summary: Vitamin C has potential as a potent anti-cancer agent when administered intravenously and in high doses. It demonstrates multi-targeting effects as a cancer-specific, pro-oxidative cytotoxic agent, anti-cancer epigenetic regulator, and immune modulator. Despite lacking strong clinical data and phase III studies, there is a need for more awareness and utilization of this promising, non-toxic cancer treatment.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

Article Oncology

Vitamin C Administration by Intravenous Infusion Increases Tumor Ascorbate Content in Patients With Colon Cancer: A Clinical Intervention Study

Gabi U. Dachs et al.

Summary: The infusion of high-dose ascorbate can increase tumor ascorbate levels and potentially modify tumor biology, with no significant adverse events observed in the clinical study.

FRONTIERS IN ONCOLOGY (2021)

Review Medicine, General & Internal

Diagnosis and Treatment of Metastatic Colorectal Cancer: A Review

Leah H. Biller et al.

Summary: Colorectal cancer is the third most common cause of cancer mortality worldwide. For patients diagnosed with metastatic colorectal cancer, approximately 70% to 75% can survive beyond 1 year. Tailoring treatments based on the molecular and pathologic features of the tumor has shown to improve overall survival rates.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Review Oncology

A Review of Colorectal Cancer in Terms of Epidemiology, Risk Factors, Development, Symptoms and Diagnosis

Tomasz Sawicki et al.

Summary: Colorectal cancer is one of the most common malignant tumors, with increasing incidence and mortality rates each year. Genetic and environmental factors, as well as lifestyle choices, play a significant role in its development. Studying the epidemiology and diagnosis of colorectal cancer is crucial for informing future strategies in disease prevention and control.

CANCERS (2021)

Review Medicine, General & Internal

Liquid Biopsy: A Family of Possible Diagnostic Tools

Battistelli Michela

Summary: Liquid biopsies are excellent diagnostic tools that can be used in various physiological or pathological conditions, including non-invasive prenatal testing and evaluating disease status and treatment methods. Biomarkers in different body fluids can be utilized for assessing pathological and non-pathological conditions.

DIAGNOSTICS (2021)

Review Biochemistry & Molecular Biology

Understanding MAPK Signaling Pathways in Apoptosis

Jicheng Yue et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Biology

The Warburg effect: essential part of metabolic reprogramming and central contributor to cancer progression

Peter Vaupel et al.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2019)

Review Oncology

Targeting cancer vulnerabilities with high-dose vitamin C

Bryan Ngo et al.

NATURE REVIEWS CANCER (2019)

Review Biochemistry & Molecular Biology

Ascorbic Acid in Colon Cancer: From the Basic to the Clinical Applications

Ibrahim El Halabi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Review Oncology

EMT and Treatment Resistance in Pancreatic Cancer

Nicola Gaianigo et al.

CANCERS (2017)

Meeting Abstract Oncology

Broad safety impact of high-dose ascorbic acid and induction chemotherapy for high-risk pancreatic cancer.

Howard Bruckner et al.

JOURNAL OF CLINICAL ONCOLOGY (2017)

Article Biochemistry & Molecular Biology

Pharmacokinetic and anti-cancer properties of high dose ascorbate in solid tumours of ascorbate-dependent mice

Elizabeth J. Campbell et al.

FREE RADICAL BIOLOGY AND MEDICINE (2016)

Article Biochemistry & Molecular Biology

L-Ascorbic acid can abrogate SVCT-2-dependent cetuximab resistance mediated by mutant KRAS in human colon cancer cells

Soo-A. Jung et al.

FREE RADICAL BIOLOGY AND MEDICINE (2016)

Review Dentistry, Oral Surgery & Medicine

Vitamin C: the known and the unknown and Goldilocks

S. J. Padayatty et al.

ORAL DISEASES (2016)

Review Biochemistry & Molecular Biology

The Warburg Effect: How Does it Benefit Cancer Cells?

Maria V. Liberti et al.

TRENDS IN BIOCHEMICAL SCIENCES (2016)

Review Endocrinology & Metabolism

New Reference Values for Vitamin C Intake

Angela Bechthold

ANNALS OF NUTRITION AND METABOLISM (2015)

Review Biochemistry & Molecular Biology

Dual Inhibition of MEK and PI3K Pathway in KRAS and BRAF Mutated Colorectal Cancers

Sally Temraz et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)

Article Oncology

Palliative Vitamin C Application in Patients with Radiotherapy-Resistant Bone Metastases: A Retrospective Study

Ayse Gunes-Bayir et al.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2015)

Review Biochemistry & Molecular Biology

Prognostic and Predictive Roles of KRAS Mutation in Colorectal Cancer

Amanda K. Arrington et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2012)

Article Oncology

Phase I clinical trial of i.v. ascorbic acid in advanced malignancy

L. J. Hoffer et al.

ANNALS OF ONCOLOGY (2008)

Review Oncology

Hypoxia, HIF1 and glucose metabolism in the solid tumour

Nicholas C. Denko

NATURE REVIEWS CANCER (2008)

Article Biochemistry & Molecular Biology

Modulation of hypoxia-inducible factor-1 alpha in cultured primary cells by intracellular ascorbate

Margret C. M. Vissers et al.

FREE RADICAL BIOLOGY AND MEDICINE (2007)

Article Medicine, General & Internal

Changes of terminal cancer patients' health-related quality of life after high dose vitamin C administration

Chang Hwan Yeom et al.

JOURNAL OF KOREAN MEDICAL SCIENCE (2007)

Article Medicine, General & Internal

Vitamin C pharmacokinetics: Implications for oral and intravenous use

SJ Padayatty et al.

ANNALS OF INTERNAL MEDICINE (2004)