Functions and mechanisms of lncRNA MALAT1 in cancer chemotherapy resistance

Chemotherapy is one of the most important treatments for cancer therapy. However, chemotherapy resistance is a big challenge in cancer treatment. Due to chemotherapy resistance, drugs become less effective or no longer effective at all. In recent years, long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been found to be associated with the development of chemotherapy resistance, suggesting that MALAT1 may be an important target to overcome chemotherapy resistance. In this review, we introduced the main mechanisms of chemotherapy resistance associated with MALAT1, which may provide new approaches for cancer treatment.

Automated summary

Chemotherapy is a crucial treatment for cancer, but the emergence of resistance poses a major challenge. Recent studies have identified a link between long non-coding RNA MALAT1 and chemotherapy resistance, suggesting its potential as a target for overcoming resistance. This review explores the mechanisms underlying MALAT1-mediated resistance and presents new possibilities for cancer treatment.