MAPK Signaling Pathways in Hepatic Ischemia/Reperfusion Injury

The mitogen-activated protein kinase signaling pathway can be activated by a variety of growth factors, cytokines, and hormones, and mediates numerous intracellular signals related to cellular activities, including cell proliferation, motility, and differentiation. It has been widely studied in the occurrence and development of inflammation and tumor. Hepatic ischemia-reperfusion injury (HIRI) is a common pathophysiological phenomenon that occurs in surgical procedures such as lobectomy and liver transplantation, which is characterized by severe inflammatory reaction after ischemia and reperfusion. In this review, we mainly discuss the role of p38, ERK1/2, JNK in MAPK family and TAK1 and ASK1 in MAPKKK family in HIRI, and try to find an effective treatment for HIRI.

Automated summary

The mitogen-activated protein kinase (MAPK) signaling pathway, which can be triggered by various growth factors, cytokines, and hormones, plays a crucial role in regulating cellular activities such as cell proliferation, motility, and differentiation. It has been extensively studied in the context of inflammation and tumor development. Hepatic ischemia-reperfusion injury (HIRI) is a common pathological phenomenon occurring during surgical procedures like lobectomy and liver transplantation, characterized by severe inflammatory reaction following ischemia and reperfusion. This review mainly focuses on discussing the roles of p38, ERK1/2, JNK in the MAPK family, as well as TAK1 and ASK1 in the MAPKKK family, in HIRI, aiming to identify effective treatments for HIRI.