4.7 Article

Mediation Analysis to Untangle Opposing Associations of High-Dose Docosahexaenoic Acid With IQ and Bronchopulmonary Dysplasia in Children Born Preterm

Related references

Note: Only part of the references are listed.
Review Medicine, General & Internal

Association Between Enteral Supplementation With High-Dose Docosahexaenoic Acid and Risk of Bronchopulmonary Dysplasia in Preterm Infants: A Systematic Review and Meta-analysis

Isabelle Marc et al.

Summary: This systematic review and meta-analysis examines the association between daily omega-3 docosahexaenoic acid (DHA) supplementation and bronchopulmonary dysplasia (BPD) in preterm infants born at less than 29 weeks' gestation. The study found that high-dose DHA supplementation during the neonatal period was not associated with BPD overall, but was inversely associated with BPD in trials that used a more stringent definition. These findings suggest that high-dose DHA supplementation should not be recommended for the prevention of BPD in very preterm infants.

JAMA NETWORK OPEN (2023)

Article Pediatrics

Maternal High-Dose DHA Supplementation and Neurodevelopment at 18-22 Months of Preterm Children

Mireille Guillot et al.

Summary: This study aimed to determine whether maternal supplementation with high-dose docosahexaenoic acid (DHA) improved neurodevelopmental outcomes in breastfed, very preterm neonates at 18 to 22 months' corrected age. The study found that overall, maternal DHA supplementation did not improve neurodevelopmental outcomes at 18 to 22 months' corrected age in breastfed, preterm neonates. However, subgroup analyses suggested a potential benefit for language in preterm neonates born before 27 weeks' gestational age.

PEDIATRICS (2022)

Article Medicine, General & Internal

Neonatal Docosahexaenoic Acid in Preterm Infants and Intelligence at 5 Years

Jacqueline F. Gould et al.

Summary: Limited research suggests that DHA supplementation in infants born before 29 weeks of gestation may have a positive impact on cognitive development.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

Article Nutrition & Dietetics

DHA supplementation in infants born preterm and the effect on attention at 18 months' corrected age: follow-up of a subset of the N3RO randomised controlled trial

Erandi Hewawasam et al.

Summary: This study found that DHA supplementation in infants born preterm did not improve attention at 18 months' corrected age.

BRITISH JOURNAL OF NUTRITION (2021)

Article Medicine, General & Internal

Protocol for assessing whether cognition of preterm infants <29 weeks' gestation can be improved by an intervention with the omega-3 long-chain polyunsaturated fatty acid docosahexaenoic acid (DHA): a follow-up of a randomised controlled trial

Jacqueline F. Gould et al.

Summary: This study aimed to determine the effect of enteral DHA supplementation in infants born before 29 weeks' gestation, particularly focusing on the impact on bronchopulmonary dysplasia. The research will also assess cognitive function in a subset of 655 children from five Australian sites, along with measuring height, weight, and head circumference. Findings will be disseminated through peer-reviewed publications and conference presentations.

BMJ OPEN (2021)

Review Medicine, General & Internal

Diagnosis and management of bronchopulmonary dysplasia

Margaret Gilfillan et al.

Summary: Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease in infants, associated with various severe consequences. Research suggests that BPD primarily affects infants born before 29 weeks' gestational age and may lead to chronic diseases in adulthood. Early diagnosis and treatment of BPD are crucial.

BMJ-BRITISH MEDICAL JOURNAL (2021)

Article Health Care Sciences & Services

Mediation effects that emulate a target randomised trial: Simulation-based evaluation of ill-defined interventions on multiple mediators

Margarita Moreno-Betancur et al.

Summary: This passage discusses epidemiological research on interventions to change the pathways of associations and proposes a novel framework for addressing methodological challenges in studying mediation effects. The focus is on simulating hypothetical interventions targeting multiple mediators and evaluating their impact, with an example application in the Victorian Adolescent Health Cohort Study.

STATISTICAL METHODS IN MEDICAL RESEARCH (2021)

Review Medicine, General & Internal

A Guideline for Reporting Mediation Analyses of Randomized Trials and Observational Studies The AGReMA Statement

Hopin Lee et al.

Summary: The AGReMA reporting guideline provides international, consensus-based guidance for conducting mediation analyses in randomized trials and observational studies, aiming to improve the transparency and reproducibility of research.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Article Critical Care Medicine

The Diagnosis of Bronchopulmonary Dysplasia in Very Preterm Infants An Evidence-based Approach

Erik A. Jensen et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2019)

Article Pediatrics

Untitled

DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY (2018)

Review Obstetrics & Gynecology

Cognitive, motor, behavioural and academic performances of children born preterm: a meta-analysis and systematic review involving 64 061 children

J. Allotey et al.

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY (2018)

Article Public, Environmental & Occupational Health

Interventional Effects for Mediation Analysis with Multiple Mediators

Stijn Vansteelandt et al.

EPIDEMIOLOGY (2017)

Article Pediatrics

Can We Define Bronchopulmonary Dysplasia?

Alan H. Jobe et al.

JOURNAL OF PEDIATRICS (2017)

Article Medicine, General & Internal

Docosahexaenoic Acid and Bronchopulmonary Dysplasia in Preterm Infants

Carmel T. Collins et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Mathematical & Computational Biology

Untitled

STATISTICS IN MEDICINE (2016)

Article Public, Environmental & Occupational Health

Analysis of Randomised Trials Including Multiple Births When Birth Size Is Informative

Lisa N. Yelland et al.

PAEDIATRIC AND PERINATAL EPIDEMIOLOGY (2015)

Article Obstetrics & Gynecology

Predictors of Bronchopulmonary Dysplasia

Andrea Trembath et al.

CLINICS IN PERINATOLOGY (2012)

Article Mathematical & Computational Biology

Improper analysis of trials randomised using stratified blocks or minimisation

Brennan C. Kahan et al.

STATISTICS IN MEDICINE (2012)