4.7 Article

Prevalence of Antiphospholipid Antibodies and Association With Incident Cardiovascular Events

Related references

Note: Only part of the references are listed.
Article Immunology

Cardiovascular disease risk in antiphospholipid syndrome: Thrombo-inflammation and atherothrombosis

Maria G. Tektonidou

Summary: Antiphospholipid syndrome (APS), an autoimmune disorder, primarily affects young adults and is characterized by the presence of antiphospholipid antibodies along with vascular manifestations. The pathogenesis of cardiovascular disease (CVD) in APS involves factors such as platelet activation, thrombosis, and the role of oxidized low-density lipoprotein. In addition, traditional risk factors including smoking, hypertension, hyperlipemia, and obesity are associated with subclinical atherosclerosis and cardiovascular events in APS.

JOURNAL OF AUTOIMMUNITY (2022)

Article Hematology

Solid Phase Assays for Antiphospholipid Antibodies

Katrien M. J. Devreese

Summary: The diagnosis of antiphospholipid syndrome relies on detecting circulating antiphospholipid antibodies, with anticardiolipin and anti-beta 2-glycoprotein I antibodies being laboratory criteria. While solid phase assays are essential for diagnosing APS, there are still substantial inter-assay differences in detecting these antibodies.

SEMINARS IN THROMBOSIS AND HEMOSTASIS (2022)

Article Rheumatology

Epidemiology of Antiphospholipid Syndrome in the General Population

Jesse Y. Dabit et al.

Summary: The epidemiology of antiphospholipid syndrome remains poorly understood, with limited population-based studies available. More research is needed to understand the prevalence and incidence of APS among diverse populations.

CURRENT RHEUMATOLOGY REPORTS (2021)

Article Multidisciplinary Sciences

Cholesterol efflux capacity and its association with prevalent metabolic syndrome in a multi-ethnic population (Dallas Heart Study)

Oludamilola Akinmolayemi et al.

Summary: The study found that regardless of the CEC assay used, CEC was negatively associated with MetS. CEC was negatively associated with waist circumference and positively associated with HDL-C, but not with other MetS components. There was an interaction by sex but not by race with regards to the association between CEC and MetS.

PLOS ONE (2021)

Article Multidisciplinary Sciences

New-onset IgG autoantibodies in hospitalized patients with COVID-19

Sarah Esther Chang et al.

Summary: In hospitalized COVID-19 patients, approximately 50% have detectable autoantibodies primarily targeting autoantigens associated with rare disorders. Additionally, a subset of autoantibodies develop de novo following SARS-CoV-2 infection.

NATURE COMMUNICATIONS (2021)

Review Medicine, Research & Experimental

The intersection of COVID-19 and autoimmunity

Jason S. Knight et al.

Summary: Severe COVID-19 may be associated with inappropriate immune responses that can trigger or exacerbate autoimmunity. Research has shown that a subset of critical COVID-19 patients develop autoantibodies, suggesting a potential link between preexisting autoimmunity and severe disease. Additionally, functional autoantibodies have been identified in some individuals following SARS-CoV-2 infection, indicating the possibility of de novo autoimmunity being triggered by the virus.

JOURNAL OF CLINICAL INVESTIGATION (2021)

Review Medicine, General & Internal

Sex Differences in Systemic Lupus Erythematosus: Epidemiology, Clinical Considerations, and Disease Pathogenesis

Julie S. Nusbaum et al.

MAYO CLINIC PROCEEDINGS (2020)

Review Medicine, General & Internal

Antiphospholipid syndrome: a clinical perspective

Yu Zuo et al.

CHINESE MEDICAL JOURNAL (2020)

Article Rheumatology

NETs in APS: Current Knowledge and Future Perspectives

Ajay Tambralli et al.

CURRENT RHEUMATOLOGY REPORTS (2020)

Article Cell Biology

Prothrombotic autoantibodies in serum from patients hospitalized with COVID-19

Yu Zuo et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

Article Hematology

New Insights in the Pathophysiology of Antiphospholipid Syndrome

Anastasia Sacharidou et al.

SEMINARS IN THROMBOSIS AND HEMOSTASIS (2018)

Review Immunology

The Contribution of Autoantibodies to Inflammatory Cardiovascular Pathology

Lee A. Meier et al.

FRONTIERS IN IMMUNOLOGY (2018)

Article Cardiac & Cardiovascular Systems

Multimodality Strategy for Cardiovascular Risk Assessment Performance in 2 Population-Based Cohorts

James A. de Lemos et al.

CIRCULATION (2017)

Article Cardiac & Cardiovascular Systems

Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis

Michael A. Gimbrone et al.

CIRCULATION RESEARCH (2016)

Letter Cardiac & Cardiovascular Systems

Antinuclear Antibodies Are Associated With All-Cause Mortality and Cardiovascular Outcomes in the General Population

Elizabeth Blair Solow et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2015)

Article Biochemistry & Molecular Biology

A sensitive assay for ABCA1-mediated cholesterol efflux using BODIPY-cholesterol

Sandhya Sankaranarayanan et al.

JOURNAL OF LIPID RESEARCH (2011)

Article Rheumatology

The United States to Africa lupus prevalence gradient revisited

G. S. Gilkeson et al.

LUPUS (2011)

Article Rheumatology

Risk factors for ANA positivity in healthy persons

Quan-Zhen Li et al.

ARTHRITIS RESEARCH & THERAPY (2011)

Article Biochemistry & Molecular Biology

Netting neutrophils in autoimmune small-vessel vasculitis

Kai Kessenbrock et al.

NATURE MEDICINE (2009)

Review Rheumatology

Ethnic and geographical variation in antiphospholipid (Hughes) syndrome

I Uthman et al.

ANNALS OF THE RHEUMATIC DISEASES (2005)

Article Immunology

Epidemiology of the antiphospholipid antibody syndrome

M Petri

JOURNAL OF AUTOIMMUNITY (2000)