☆ 4.6 Article

Combining skin and olfactory α-synuclein seed amplification assays (SAA)-towards biomarker-driven phenotyping in synucleinopathies

NPJ PARKINSONS DISEASE (2023)

Related references

Note: Only part of the references are listed.

Article Biochemical Research Methods

Seed amplification assay for the detection of pathologic alpha-synuclein aggregates in cerebrospinal fluid

Luis Concha-Marambio et al.

Summary: Misfolded alpha-synuclein aggregates can be amplified in vitro using alpha Syn seed amplification assays, which have shown promise as a biochemical test for synucleinopathies. This assay can detect alpha Syn aggregates in cerebrospinal fluid samples from patients with Parkinson's disease, dementia with Lewy bodies, or multiple-system atrophy, and distinguish between samples from patients with Parkinson's disease and those with multiple-system atrophy.

NATURE PROTOCOLS (2023)

Add to Collection

Article Neurosciences

Alpha-synuclein seeding shows a wide heterogeneity in multiple system atrophy

Ivan Martinez-Valbuena et al.

Summary: This study revealed significant differences in the seeding activity of alpha-synuclein in the brains of patients with Multiple System Atrophy (MSA), as well as regional variations within individual brains. These findings provide important experimental groundwork for future subclassification and rapid diagnostic assays for MSA.

TRANSLATIONAL NEURODEGENERATION (2022)

Add to Collection

Article Clinical Neurology

Effect of olfactory bulb pathology on olfactory function in normal aging

Cecilia Tremblay et al.

Summary: The decline of olfactory function is frequently observed in aging. This study found that tau pathology is commonly observed in the olfactory bulb of normally aging individuals, but it does not independently contribute to age-related olfactory decline. Further involvement of the brain seems to be necessary for age-related olfactory impairment.

BRAIN PATHOLOGY (2022)

Add to Collection

Article Clinical Neurology

Association between probable REM sleep behavior disorder and increased dermal alpha-synuclein deposition in Parkinson's disease

K. Doppler et al.

Summary: In patients with Parkinson's disease, the presence of REM sleep behavior disorder is associated with higher frequency and abundance of dermal alpha-synuclein deposition, resembling those with isolated REM sleep behavior disorder. This suggests a potential link between REM sleep behavior disorder and a specific subtype of Parkinson's disease characterized by peripheral nerve involvement.

PARKINSONISM & RELATED DISORDERS (2022)

Add to Collection

Review Geriatrics & Gerontology

Alpha-Synuclein Strain Variability in Body-First and Brain-First Synucleinopathies

Mie Kristine Just et al.

Summary: Pathogenic alpha-synuclein aggregates are a defining feature of neurodegenerative synucleinopathies. Early differentiation between these diseases is challenging due to clinical heterogeneity. However, recent advancements in seed amplification assays and conformation-specific ligand assays show promise in differentiating synucleinopathies.

FRONTIERS IN AGING NEUROSCIENCE (2022)

Add to Collection

Article Neurosciences

A postmortem study suggests a revision of the dual-hit hypothesis of Parkinson's disease

Per Borghammer et al.

Summary: The dual-hit hypothesis of Parkinson's disease suggests that a neurotropic pathogen leads to formation of alpha-synuclein pathology that enters the brain from the olfactory bulb and the dorsal motor nucleus of the vagus. However, a re-analysis of postmortem datasets found that early body-first Lewy body disease (LBD) cases rarely had olfactory bulb pathology, while early brain-first LBD cases almost always showed olfactory bulb pathology. This supports the idea that the pathological process starts in either the olfactory bulb or the enteric nervous system, but not both simultaneously.

NPJ PARKINSONS DISEASE (2022)

Add to Collection

Article Neurosciences

Olfactory swab sampling optimization for α-synuclein aggregate detection in patients with Parkinson's disease

Matilde Bongianni et al.

Summary: This study found that nasal swab testing performed at the agger nasi significantly increased the sensitivity of real-time quaking-induced conversion (RT-QuIC) detection of pathological alpha-synuclein in patients with Parkinson's disease (PD). The study also observed the presence of alpha-synuclein and phospho-alpha-synuclein deposits in nasal swabs from PD patients.

TRANSLATIONAL NEURODEGENERATION (2022)

Add to Collection

Review Neurosciences

Opportunities and challenges of alpha-synuclein as a potential biomarker for Parkinson's disease and other synucleinopathies

Pedro Magalhaes et al.

Summary: This review provides an overview of the distribution of alpha-synuclein (aSyn) species in the brain, peripheral tissues, and biological fluids. It analyses previous studies on measuring total aSyn and other modified and aggregated forms of aSyn in different biological fluids. It highlights the conceptual and technical gaps and challenges in developing and validating reliable aSyn biomarkers and proposes recommendations to address these challenges.

NPJ PARKINSONS DISEASE (2022)

Add to Collection

Article Clinical Neurology

Skin α-Synuclein Aggregation Seeding Activity as a Novel Biomarker for Parkinson Disease

Zerui Wang et al.

Summary: The study demonstrates that skin alpha Syn(P) seeding activity can potentially serve as a novel biomarker for antemortem diagnosis of Parkinson disease (PD) and other synucleinopathies. The analysis of skin samples from autopsies and biopsies shows a significant increase in alpha Syn(P) seeding activity in individuals with PD and synucleinopathies compared to controls with tauopathies and non-neurodegenerative diseases.

JAMA NEUROLOGY (2021)

Add to Collection

Article Clinical Neurology

The Rostock International Parkinson's Disease (ROPAD) Study: Protocol and Initial Findings

Volha Skrahina et al.

Summary: The ROPAD study aims to genetically characterize around 10,000 Parkinson's disease patients, with initial data from 1360 participants indicating a genetic diagnostic yield of approximately 14%. This demonstrates the feasibility and effectiveness of the screening protocol for high-throughput genetic characterization and prioritization for research efforts and clinical trials.

MOVEMENT DISORDERS (2021)

Add to Collection

Article Neurosciences

Discrimination of MSA-P and MSA-C by RT-QuIC analysis of olfactory mucosa: the first assessment of assay reproducibility between two specialized laboratories

Connor Bargar et al.

Summary: The study demonstrates that OM-alpha Syn(D) could serve as a novel biomarker for the accurate clinical diagnoses of PD, MSA-P, and MSA-C. Additionally, alpha Syn_RT-QuIC is a reliable assay that can distinguish between MSA-P and MSA-C patients, potentially leading to advancements in patient stratification for emerging pharmacological treatments and clinical trials.

MOLECULAR NEURODEGENERATION (2021)

Add to Collection

Article Neurosciences

Neuropathological evidence of body-first vs. brain-first Lewy body disease

Per Borghammer et al.

Summary: The aggregation of alpha-synuclein into inclusion bodies, known as Lewy pathology, is a key feature of Parkinson's disease and Dementia with Lewy bodies. Post mortem studies have shown that Lewy pathology follows two main distribution patterns in the brain, with some patients having pathogenic alpha-synuclein originating in the enteric nervous system and others originating inside the central nervous system.

NEUROBIOLOGY OF DISEASE (2021)

Add to Collection

Article Clinical Neurology

Alpha-synuclein seeds in olfactory mucosa of patients with isolated REM sleep behaviour disorder

Ambra Stefani et al.

Summary: RT-QuIC detection of alpha-synuclein aggregates in olfactory mucosa showed a linkage between alpha-synuclein pathology and olfactory dysfunction in patients with isolated RBD and Parkinson's disease, indicating a potential for early detection and preventive therapies.

BRAIN (2021)

Add to Collection

Article Neurosciences

Diagnostic value of skin RT-QuIC in Parkinson's disease: a two-laboratory study

Anastasia Kuzkina et al.

Summary: The α-synuclein RT-QuIC assay from minimally invasive skin punch biopsy is a reliable and reproducible biomarker for Parkinson's disease, showing high diagnostic accuracy and inter-rater agreement. The seeding activity correlates with disease progression and certain non-motor symptoms.

NPJ PARKINSONS DISEASE (2021)

Add to Collection

Review Clinical Neurology

Prodromal Parkinson disease subtypes - key to understanding heterogeneity

Daniela Berg et al.

Summary: Parkinson's disease begins its pathological processes and neurodegeneration long before clinical diagnosis, allowing for identification of individuals likely to develop the disease through risk and prodromal markers. Heterogeneity in clinical and prodromal PD suggests that subtypes exist, differentiated by clinical manifestations, pathomechanisms, and progression patterns. Understanding this variability is crucial for early and accurate diagnosis, as well as for targeting neuroprotective interventions effectively.

NATURE REVIEWS NEUROLOGY (2021)

Add to Collection

Article Multidisciplinary Sciences

Discriminating α-synuclein strains in Parkinson's disease and multiple system atrophy

Mohammad Shahnawaz et al.

NATURE (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Potential sources of interference with the highly sensitive detection and quantification of alpha-synuclein seeds by qRT-QuIC

Viktoria C. Ruf et al.

FEBS OPEN BIO (2020)

Add to Collection

Article Neurosciences

The clinical heterogeneity of Parkinson's disease and its therapeutic implications

Julia C. Greenland et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2019)

Add to Collection

Article Behavioral Sciences

Differential Expression of Mucins in Murine Olfactory Versus Respiratory Epithelium

Christopher Kennel et al.

CHEMICAL SENSES (2019)

Add to Collection

Article Clinical Neurology

Unified Staging System for Lewy Body Disorders: Clinicopathologic Correlations and Comparison to Braak Staging

Charles H. Adler et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2019)

Add to Collection

Review Clinical Neurology

Update of the MDS research criteria for prodromal Parkinson's disease

Sebastian Heinzel et al.

MOVEMENT DISORDERS (2019)

Add to Collection

Article Neurosciences

Efficient RT-QuIC seeding activity for α-synuclein in olfactory mucosa samples of patients with Parkinson's disease and multiple system atrophy

Chiara Maria Giulia De Luca et al.

TRANSLATIONAL NEURODEGENERATION (2019)

Add to Collection

Article Clinical Neurology

Neocortical Lewy bodies are associated with impaired odor identification in community-dwelling elders without clinical PD

Sukriti Nag et al.

JOURNAL OF NEUROLOGY (2019)

Add to Collection

Article Microbiology

Modified Protein Misfolding Cyclic Amplification Overcomes Real-Time Quaking-Induced Conversion Assay Inhibitors in Deer Saliva To Detect Chronic Wasting Disease Prions

Kristen A. Davenport et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2018)

Add to Collection

Review Clinical Neurology

Biomarker-Driven Phenotyping in Parkinson's Disease: A Translational Missing Link in Disease-Modifying Clinical Trials

Alberto J. Espay et al.

MOVEMENT DISORDERS (2017)

Add to Collection

Article Clinical Neurology

Diagnosis of Human Prion Disease Using Real-Time Quaking-Induced Conversion Testing of Olfactory Mucosa and Cerebrospinal Fluid Samples

Matilde Bongianni et al.

JAMA NEUROLOGY (2017)

Add to Collection

Article Multidisciplinary Sciences

Detection of prion seeding activity in the olfactory mucosa of patients with Fatal Familial Insomnia

Veronica Redaelli et al.

SCIENTIFIC REPORTS (2017)

Add to Collection

Article Neurosciences

Stability and Reproducibility Underscore Utility of RT-QuIC for Diagnosis of Creutzfeldt-Jakob Disease

Maria Cramm et al.

MOLECULAR NEUROBIOLOGY (2016)

Add to Collection

Article Neurosciences

High-Throughput Mapping of Single-Neuron Projections by Sequencing of Barcoded RNA

Justus M. Kebschull et al.

NEURON (2016)

Add to Collection

Review Clinical Neurology

MDS clinical diagnostic criteria for Parkinson's disease

Ronald B. Postuma et al.

MOVEMENT DISORDERS (2015)

Add to Collection

Article Clinical Neurology

Parkinson disease and incidental Lewy body disease Just a question of time?

Diego Iacono et al.

NEUROLOGY (2015)

Add to Collection

Article Statistics & Probability

Building Bivariate Tables: ThecompareGroupsPackage forR

Isaac Subirana et al.

Journal of Statistical Software (2015)

Add to Collection

Article Clinical Neurology

Cutaneous neuropathy in Parkinson's disease: a window into brain pathology

Kathrin Doppler et al.

ACTA NEUROPATHOLOGICA (2014)

Add to Collection

Article Medicine, General & Internal

A Test for Creutzfeldt-Jakob Disease Using Nasal Brushings

Christina D. Orru et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Add to Collection

Article Clinical Neurology

Olfactory dysfunction in incidental Lewy body disease and Parkinson's disease

Erika Driver-Dunckley et al.

PARKINSONISM & RELATED DISORDERS (2014)

Add to Collection

Review Neurosciences

A lifetime of neurogenesis in the olfactory system

Jessica H. Brann et al.

FRONTIERS IN NEUROSCIENCE (2014)

Add to Collection

Article Clinical Neurology

The coeruleus/subcoeruleus complex in rapid eye movement sleep behaviour disorders in Parkinson's disease

Daniel Garcia-Lorenzo et al.

BRAIN (2013)

Add to Collection

Article Neurosciences

Aggregation and neurotoxicity of recombinant α-synuclein aggregates initiated by dimerization

Alireza Roostaee et al.

MOLECULAR NEURODEGENERATION (2013)

Add to Collection

Article Clinical Neurology

α-Synuclein in cutaneous autonomic nerves

Ningshan Wang et al.

NEUROLOGY (2013)

Add to Collection

Article Clinical Neurology

Rapid eye movement sleep behavior disorder: devising controlled active treatment studies for symptomatic and neuroprotective therapy-a consensus statement from the International Rapid Eye Movement Sleep Behavior Disorder Study Group

C. H. Schenck et al.

SLEEP MEDICINE (2013)

Add to Collection

Article Otorhinolaryngology

Olfactory neuroepithelium in the superior and middle turbinates: which is the optimal biopsy site?

Fabio de Rezende Pinna et al.

INTERNATIONAL ARCHIVES OF OTORHINOLARYNGOLOGY (2013)

Add to Collection

Article Clinical Neurology

A single-question screen for rapid eye movement sleep behavior disorder: A multicenter validation study

Ronald B. Postuma et al.

MOVEMENT DISORDERS (2012)

Add to Collection

Article Clinical Neurology

Lewy pathology is not the first sign of degeneration in vulnerable neurons in Parkinson disease

Joshua M. Milber et al.

NEUROLOGY (2012)

Add to Collection

Article Microbiology

Prion Disease Blood Test Using Immunoprecipitation and Improved Quaking-Induced Conversion

Christina D. Orru et al.

MBIO (2011)

Add to Collection

Article Behavioral Sciences

Parkinson's Disease The Dual Hit Theory Revisited

Christopher H. Hawkes et al.

INTERNATIONAL SYMPOSIUM ON OLFACTION AND TASTE (2009)

Add to Collection

Article Clinical Neurology

Biopsies of Olfactory Epithelium in Patients with Parkinson's Disease

Martin Witt et al.

MOVEMENT DISORDERS (2009)

Add to Collection

Article Clinical Neurology

Applicability of current staging/categorization of α-synuclein pathology and their clinical relevance

Laura Parkkinen et al.

ACTA NEUROPATHOLOGICA (2008)

Add to Collection

Article Clinical Neurology

Incidental Lewy body disease and preclinical Parkinson disease

Anthony DelleDonne et al.

ARCHIVES OF NEUROLOGY (2008)

Add to Collection

Article Clinical Neurology

The dorsal motor nucleus of the vagus is not an obligatory trigger site of Parkinson's disease:: a critical analysis of α-synuclein staging

M. E. Kalaitzakis et al.

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2008)

Add to Collection

Article Psychology, Mathematical

G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences

Franz Faul et al.

BEHAVIOR RESEARCH METHODS (2007)

Add to Collection

Article Clinical Neurology

Association of olfactory dysfunction with incidental Lewy bodies

G. Webster Ross et al.

MOVEMENT DISORDERS (2006)

Add to Collection

Article Clinical Neurology

International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson's disease: The NMSQuest study

Kallol Ray Chaudhuri et al.

MOVEMENT DISORDERS (2006)

Add to Collection

Article Allergy

Mucin genes have different expression patterns in healthy and diseased upper airway mucosa

A Martínez-Antón et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2006)

Add to Collection

Article Biochemistry & Molecular Biology

Cysteine misincorporation in bacterially expressed human α-synuclein

M Masuda et al.

FEBS LETTERS (2006)

Add to Collection

Review Geriatrics & Gerontology

Staging of brain pathology related to sporadic Parkinson's disease

H Braak et al.

NEUROBIOLOGY OF AGING (2003)

Add to Collection

© Peeref 2019-2024. All rights reserved.