4.8 Article

Peripheral blood mononuclear cell mitochondrial dysfunction in acute alcohol-associated hepatitis

Related references

Note: Only part of the references are listed.
Article Gastroenterology & Hepatology

IL-1 receptor antagonist plus pentoxifylline and zinc for severe alcohol-associated hepatitis

Gyongyi Szabo et al.

Summary: Combination therapy of anakinra, pentoxifylline, and zinc provides similar survival benefits compared to corticosteroid therapy in severe alcohol-associated hepatitis.

HEPATOLOGY (2022)

Review Medicine, Research & Experimental

Mitochondrial dysfunction in cell senescence and aging

Satomi Miwa et al.

Summary: This article summarizes the importance of mitochondrial dysfunction in aging and cell senescence, discusses its relationship with cellular senescence, and proposes an anti-aging therapy that targets mitochondrial dysfunction.

JOURNAL OF CLINICAL INVESTIGATION (2022)

Article Medicine, Research & Experimental

Metabolic reprogramming during hyperammonemia targets mitochondrial function and postmitotic senescence

Avinash Kumar et al.

Summary: The dysregulated metabolism of ammonia causes reversible mitochondrial dysfunction and induces skeletal muscle senescence through transcriptional and translational perturbations. Multiomics analysis showed the impacts of ammonia lowering on mitochondrial function and protein expression. Dysregulated ammonia metabolism led to reversible defects in electron transport chain complexes and senescence-related molecular changes in skeletal muscle.

JCI INSIGHT (2021)

Article Biochemistry & Molecular Biology

Integrated multiomics analysis identifies molecular landscape perturbations during hyperammonemia in skeletal muscle and myotubes

Nicole Welch et al.

Summary: This study utilized a multiomics approach to analyze molecular changes during hyperammonemia in muscle tissues, revealing various types of responses including mitochondrial and oxidative dysfunction, disruption of protein homeostasis, and activation of oxidative stress pathways. Additionally, novel observations were made, such as an increase in expression of antiapoptotic proteins, increased calcium flux, and increased protein glycosylation during hyperammonemia. The data demonstrate complex molecular interactions during adaptive and maladaptive responses to cellular stress induced by hyperammonemia.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

Article Gastroenterology & Hepatology

Differential blood transcriptome modules predict response to corticosteroid therapy in alcoholic hepatitis

Shvetank Sharma et al.

Summary: In patients with severe alcoholic hepatitis, those who do not respond to steroids show higher activity of gene modules related to T and B cells, NK cells, and mitochondrial electron transport chain in PBMCs at baseline and during corticosteroid therapy compared to steroid responders.

JHEP REPORTS (2021)

Article Biochemistry & Molecular Biology

MitoCarta3.0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations

Sneha Rath et al.

Summary: MitoCarta3.0 is a catalog of over 1000 genes encoding the mammalian mitochondrial proteome, with 1136 human genes after manual review. It includes annotations of sub-mitochondrial localization and hierarchical 'MitoPathways', serving as a valuable resource for mitochondrial biology and medicine.

NUCLEIC ACIDS RESEARCH (2021)

Article Medicine, General & Internal

Plasma Krebs Cycle Intermediates in Nonalcoholic Fatty Liver Disease

Yana Sandlers et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Article Biochemistry & Molecular Biology

A novel approach to measure mitochondrial respiration in frozen biological samples

Rebeca Acin-Perez et al.

EMBO JOURNAL (2020)

Article Gastroenterology & Hepatology

Functionally Diverse Inflammatory Responses in Peripheral and Liver Monocytes in Alcohol-Associated Hepatitis

Adam Kim et al.

HEPATOLOGY COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

Ethanol sensitizes skeletal muscle to ammonia-induced molecular perturbations

Sashi Kant et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

Review Immunology

An Overview of Peripheral Blood Mononuclear Cells as a Model for Immunological Research of Toxoplasma gondii and Other Apicomplexan Parasites

John Alejandro Acosta Davila et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2019)

Article Biochemistry & Molecular Biology

Oxidative stress mediates ethanol-induced skeletal muscle mitochondrial dysfunction and dysregulated protein synthesis and autophagy

Avinash Kumar et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

Review Biology

Mitochondrial Dysfunction and the Aging Immune System

Peter J. McGuire

BIOLOGY-BASEL (2019)

Article Biotechnology & Applied Microbiology

Integrating single-cell transcriptomic data across different conditions, technologies, and species

Andrew Butler et al.

NATURE BIOTECHNOLOGY (2018)

Article Pathology

Regulation of Cellular Senescence by miR-34a in Alcoholic Liver Injury

Ying Wan et al.

AMERICAN JOURNAL OF PATHOLOGY (2017)

Article Gastroenterology & Hepatology

Immune dysfunction in acute alcoholic hepatitis

Ashwin D. Dhanda et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2015)

Article Multidisciplinary Sciences

Serum Metabolomic Profiling in Acute Alcoholic Hepatitis Identifies Multiple Dysregulated Pathways

Vikrant Rachakonda et al.

PLOS ONE (2014)

Article Medicine, General & Internal

Mediterranean diet and telomere length in Nurses' Health Study: population based cohort study

Marta Crous-Bou et al.

BMJ-BRITISH MEDICAL JOURNAL (2014)

Review Geriatrics & Gerontology

Is Telomere Length a Biomarker of Aging? A Review

Karen Anne Mather et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2011)

Article Mathematical & Computational Biology

Youden index and optimal cut-point estimated from observations affected by a lower limit of detection

Marcus D. Ruopp et al.

BIOMETRICAL JOURNAL (2008)

Article Agriculture, Multidisciplinary

Effects of alcohol-induced human peripheral blood mononuclear cell (PBMC) pretreated whey protein concentrate (WPC) on oxidative damage

Yang-Ming Tseng et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2008)

Article Biochemical Research Methods

Analysis of mitochondrial function in situ in permeabilized muscle fibers, tissues and cells

Andrey V. Kuznetsov et al.

NATURE PROTOCOLS (2008)

Article Geriatrics & Gerontology

A continuous correlation between oxidative stress and telomere shortening in fibroblasts

Torsten Richter et al.

EXPERIMENTAL GERONTOLOGY (2007)

Article Biochemical Research Methods

Maximizing the retention of antigen specific lymphocyte function after cryopreservation

ML Disis et al.

JOURNAL OF IMMUNOLOGICAL METHODS (2006)

Review Geriatrics & Gerontology

Mitochondria, telomeres and cell senescence

JF Passos et al.

EXPERIMENTAL GERONTOLOGY (2005)

Review Gastroenterology & Hepatology

Alcohol and mitochondria: A dysfunctional relationship

JB Hoek et al.

GASTROENTEROLOGY (2002)