4.8 Article

CD47KO/CRT dual-bioengineered cell membrane-coated nanovaccine combined with anti-PD-L1 antibody for boosting tumor immunotherapy

Related references

Note: Only part of the references are listed.
Review Biotechnology & Applied Microbiology

Identification of tumor antigens with immunopeptidomics

Chloe Chong et al.

Summary: Identification of actionable tumor antigens is crucial for various cancer immunotherapies, including T cell receptor-transduced T cells and patient-specific mRNA or peptide vaccines. By eluting human leukocyte antigen-bound peptides from tumors and subjecting these to mass spectrometry analysis, noncanonical antigens can be discovered, which may lead to more effective treatment options.

NATURE BIOTECHNOLOGY (2022)

Article Biotechnology & Applied Microbiology

Engineered a dual-targeting biomimetic nanomedicine for pancreatic cancer chemoimmunotherapy

Meng Wang et al.

Summary: The dual-targeting nanomedicine, PG@KMCM, was developed to target tumor-associated macrophages and reprogram the tumor microenvironment, enhancing the therapeutic potential against pancreatic cancer. Combination with PD-L1 immune checkpoint inhibitor further improved the anti-tumoral effect by reprograming the immune-suppressive tumor microenvironment.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

Article Engineering, Biomedical

Combining mannose receptor mediated nanovaccines and gene regulated PD-L1 blockade for boosting cancer immunotherapy

Jie Chen et al.

Summary: This study explores an intensive tumor immunotherapeutic strategy by combining mannosylated nanovaccines with gene regulated PD-L1 blockade. The mannose modified nanovaccines can effectively co-encapsulate antigen and adjuvant, promoting endocytosis and cross presentation in dendritic cells. However, the limited inhibition of tumor growth by nanovaccines in the immunosuppressed tumor microenvironment can be overcome by combining with gene regulated PD-L1 blockade, leading to significant tumor remission.

BIOACTIVE MATERIALS (2022)

Review Engineering, Biomedical

White Blood Cell Membrane-Coated Nanoparticles: Recent Development and Medical Applications

Dan Wang et al.

Summary: White blood cell membrane-coated nanoparticles (WBC-NPs) are a novel type of nanomaterial with wide-ranging medical applications, including drug delivery, biological neutralization, immune modulation, and tumor cell isolation. By fusing the plasma membranes of white blood cells, WBC-NPs inherit the antigenic properties of the source cells and exhibit broad biointerfacing properties.

ADVANCED HEALTHCARE MATERIALS (2022)

Article Engineering, Biomedical

Engineered extracellular vesicles for concurrent Anti-PDL1 immunotherapy and chemotherapy

Yundi Chen et al.

Summary: Research shows that engineered universal EVs carrying PD-1 proteins are effective in reducing cancer cell proliferation, inducing apoptosis, and blocking PD-L1 mediated T cell suppression. These EVs demonstrate strong anti-tumor activity in tumor models, with efficacy comparable to clinical anti-PD1 monoclonal antibodies.

BIOACTIVE MATERIALS (2022)

Article Multidisciplinary Sciences

Identification of a subset of immunosuppressive P2RX1-negative neutrophils in pancreatic cancer liver metastasis

Xu Wang et al.

Summary: A subset of immunosuppressive P2RX1-negative neutrophils accumulate in the liver metastases of pancreatic ductal adenocarcinoma (PDAC), expressing increased levels of immunosuppressive molecules such as PD-L1 and having enhanced mitochondrial metabolism. The upregulation of the transcription factor Nrf2 in P2RX1-deficient neutrophils is associated with PD-L1 expression and metabolic reprogramming, contributing to the evasion of antitumor immunity by metastatic PDAC tumors.

NATURE COMMUNICATIONS (2021)

Article Oncology

Evorpacept alone and in combination with pembrolizumab or trastuzumab in patients with advanced solid tumours (ASPEN-01): a first-in-human, open-label, multicentre, phase 1 dose-escalation and dose-expansion study

Nehal J. Lakhani et al.

Summary: The study evaluated the safety, pharmacokinetics, pharmacodynamics, and anticancer activity of a new drug in patients with solid tumors. The results suggest that this new drug in combination with other medications may have potential therapeutic effects for patients with advanced solid tumors.

LANCET ONCOLOGY (2021)

Article Biochemistry & Molecular Biology

Immune responses to two and three doses of the BNT162b2 mRNA vaccine in adults with solid tumors

Rachna T. Shroff et al.

Summary: Cancer patients showed diminished immune responses to the BNT162b2 mRNA vaccine compared to the control group, but a third dose of the vaccine was found to be safe and significantly improved humoral immunity against SARS-CoV-2.

NATURE MEDICINE (2021)

Editorial Material Chemistry, Multidisciplinary

Engineering biomimetic epigenetic nanoinducer improves cancer immunotherapy

Yuliang Zhao

SCIENCE CHINA-CHEMISTRY (2021)

Article Multidisciplinary Sciences

Synergistic effect of tumor chemo-immunotherapy induced by leukocyte-hitchhiking thermal-sensitive micelles

Jing Qi et al.

Summary: The study introduces E-selectin-modified thermal-sensitive micelles loaded with doxorubicin and an adenosine A2 receptor antagonist to enhance chemotherapy-induced anti-tumor immune responses. This strategy not only increases the tumor accumulation of drugs by hitchhiking with leukocytes, but also improves the immunotherapeutic effects of chemotherapy drugs.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

Genetically engineered cell membrane-coated nanoparticles for targeted delivery of dexamethasone to inflamed lungs

Joon Ho Park et al.

Summary: By exploiting the specific affinity between VLA-4 and VCAM-1, a biomimetic nanoparticle formulation capable of targeting inflammation sites was developed. These nanoparticles coated with cell membranes showed enhanced affinity to target cells, improving the delivery of anti-inflammatory drugs to inflamed lungs and demonstrating significant therapeutic efficacy in vivo.

SCIENCE ADVANCES (2021)

Article Multidisciplinary Sciences

Combination of epigenetic regulation with gene therapy-mediated immune checkpoint blockade induces anti-tumour effects and immune response in vivo

Huapan Fang et al.

Summary: While immunotherapy has shown promise as a cancer treatment, durable benefits are often limited by immune escape mechanisms. This study combines epigenetic regulation with gene therapy for immune checkpoint blockade to enhance anti-tumor effects and immune responses in vivo, providing a potential strategy for tumor treatment and prevention of relapse and metastasis.

NATURE COMMUNICATIONS (2021)

Review Oncology

Therapeutic cancer vaccines

Mansi Saxena et al.

Summary: Therapeutic cancer vaccines aim to induce tumor regression, eradicate minimal residual disease, establish lasting anti-tumor memory, and avoid non-specific or adverse reactions. However, challenges arise due to tumor-induced immunosuppression and immunoresistance, hindering the achievement of these goals.

NATURE REVIEWS CANCER (2021)

Article Multidisciplinary Sciences

Vaccination with CD47 deficient tumor cells elicits an antitumor immune response in mice

Yang Li et al.

NATURE COMMUNICATIONS (2020)

Review Oncology

Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

Lorenzo Galluzzi et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

Article Multidisciplinary Sciences

The pore size of mesoporous silica nanoparticles regulates their antigen delivery efficiency

Xiaoyu Hong et al.

SCIENCE ADVANCES (2020)

Review Cell Biology

Resistance Mechanisms of Anti-PD1/PDL1 Therapy in Solid Tumors

Qingyang Lei et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Review Cell Biology

Detection of immunogenic cell death and its relevance for cancer therapy

Jitka Fucikova et al.

CELL DEATH & DISEASE (2020)

Article Multidisciplinary Sciences

T cell stemness and dysfunction in tumors are triggered by a common mechanism

Suman Kumar Vodnala et al.

SCIENCE (2019)

Article Materials Science, Biomaterials

Zinc ion coordination significantly improved the transfection efficiency of low molecular weight polyethylenimine

Huapan Fang et al.

BIOMATERIALS SCIENCE (2019)

Review Biochemistry & Molecular Biology

Understanding the tumor immune microenvironment (TIME) for effective therapy

Mikhail Binnewies et al.

NATURE MEDICINE (2018)

Review Multidisciplinary Sciences

Personalized vaccines for cancer immunotherapy

Ugur Sahin et al.

SCIENCE (2018)

Review Immunology

SIRPα-CD47 Immune Checkpoint Blockade in Anticancer Therapy

Andre Veillette et al.

TRENDS IN IMMUNOLOGY (2018)

Article Multidisciplinary Sciences

An immunogenic personal neoantigen vaccine for patients with melanoma

Patrick A. Ott et al.

NATURE (2017)

Article Multidisciplinary Sciences

A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer

Paola A. Betancur et al.

NATURE COMMUNICATIONS (2017)

Article Chemistry, Multidisciplinary

Nanoparticulate Delivery of Cancer Cell Membrane Elicits Multiantigenic Antitumor Immunity

Ashley V. Kroll et al.

ADVANCED MATERIALS (2017)

Review Immunology

Immunogenic cell death in cancer and infectious disease

Lorenzo Galluzzi et al.

NATURE REVIEWS IMMUNOLOGY (2017)

Meeting Abstract Oncology

Bispecific antibody targeting of CD47/CD19 to promote enhanced phagocytosis of patient B lymphoma cells.

Zoe Johnson et al.

JOURNAL OF CLINICAL ONCOLOGY (2015)

Article Chemistry, Multidisciplinary

Cancer Cell Membrane-Coated Nanoparticles for Anticancer Vaccination and Drug Delivery

Ronnie H. Fang et al.

NANO LETTERS (2014)

Review Biotechnology & Applied Microbiology

Adenosine receptors:: therapeutic aspects for inflammatory and immune diseases

Gyorgy Hasko et al.

NATURE REVIEWS DRUG DISCOVERY (2008)

Article Biochemistry & Molecular Biology

Calreticulin exposure dictates the immunogenicity of cancer cell death

Michel Obeid et al.

NATURE MEDICINE (2007)