4.8 Review

Genetic scissors CRISPR/Cas9 genome editing cutting-edge biocarrier technology for bone and cartilage repair

Journal

BIOACTIVE MATERIALS
Volume 22, Issue -, Pages 254-273

Publisher

KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2022.09.026

Keywords

CRISPR; Cas9; Genome editing; Bone repair; Cartilage repair

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CRISPR/Cas9 is a revolutionary genome editing technology with numerous advantages and great potential in bone and cartilage repair. This review discusses the research status and development trends of CRISPR/Cas9 in bone and cartilage repair.
CRISPR/Cas9 is a revolutionary genome editing technology with the tremendous advantages such as precisely targeting/shearing ability, low cost and convenient operation, becoming an efficient and indispensable tool in biological research. As a disruptive technique, CRISPR/Cas9 genome editing has a great potential to realize a future breakthrough in the clinical bone and cartilage repairing as well. This review highlights the research status of CRISPR/Cas9 system in bone and cartilage repair, illustrates its mechanism for promoting osteogenesis and chondrogenesis, and explores the development tendency of CRISPR/Cas9 in bone and cartilage repair to over-come the current limitations.

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