Location-aware ingestible microdevices for wireless monitoring of gastrointestinal dynamics

Wireless ingestible microdevices can be tracked through the gastrointestinal tract of large animals in real time and with millimetre-scale spatial resolution by generating three-dimensional magnetic field gradients in the gastrointestinal field-of-view using high-efficiency planar electromagnetic coils, which encode each spatial point with a distinct magnetic field magnitude. Localization and tracking of ingestible microdevices in the gastrointestinal (GI) tract is valuable for the diagnosis and treatment of GI disorders. Such systems require a large field-of-view of tracking, high spatiotemporal resolution, wirelessly operated microdevices and a non-obstructive field generator that is safe to use in practical settings. However, the capabilities of current systems remain limited. Here, we report three dimensional (3D) localization and tracking of wireless ingestible microdevices in the GI tract of large animals in real time and with millimetre-scale resolution. This is achieved by generating 3D magnetic field gradients in the GI field-of-view using high-efficiency planar electromagnetic coils that encode each spatial point with a distinct magnetic field magnitude. The field magnitude is measured and transmitted by the miniaturized, low-power and wireless microdevices to decode their location as they travel through the GI tract. This system could be useful for quantitative assessment of the GI transit-time, precision targeting of therapeutic interventions and minimally invasive procedures.

Automated summary

Wireless ingestible microdevices can be tracked in real time and with millimetre-scale resolution through the GI tract by generating three-dimensional magnetic field gradients using high-efficiency planar electromagnetic coils. This technology has the potential to improve the diagnosis and treatment of GI disorders by enabling quantitative assessment of GI transit-time, precision targeting of therapeutic interventions, and minimally invasive procedures.