Journal
LIPIDS
Volume 51, Issue 8, Pages 989-995Publisher
WILEY
DOI: 10.1007/s11745-016-4172-7
Keywords
Sorbus commixta; Rosaceae; Fatty acids; Neuroprotection; Anti-neuroinflammation
Funding
- Basic Science Research Program through National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [2013R1A1A2A10005315]
- High Value-added Food Technology Development Program, Ministry of Agriculture, Food and Rural Affairs [114006041HD020]
- Institute of Planning & Evaluation for Technology in Food, Agriculture, Forestry & Fisheries (iPET), Republic of Korea [114006041HD020] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Phytochemical investigation of the bark from the stems of Sorbus commixta led to the isolation and characterization of a new fatty acid, sorcomic acid (1), along with nine known analogues (2-10). The structure of the new compound (1) was determined through NMR (H-1 and C-13 NMR, HSQC, HMBC, and NOESY), MS, and specific optical rotation. The known compounds (2-10) were identified by comparison of their spectroscopic data with those in the literature. The biological activities of all the isolated compounds (1-10) were evaluated: compounds 1, 5, and 7 potently induced NGF secretion from C6 glioma cells (233.40 +/- 12.82, 194.40 +/- 8.05, and 185.74 +/- 10.25 %, respectively) and compound 10 reduced NO levels with an IC50 value of 71.25 mu M in murine microglia BV2 cells stimulated by LPS.
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