Journal
FRONTIERS IN VETERINARY SCIENCE
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fvets.2023.1169617
Keywords
dog; stroke; cerebrovascular accident; cerebrospinal fluid; cytokine; chemokine; CXCL1; MCP-1
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This study evaluated the levels of pro- and anti-inflammatory cytokines in dogs with stroke and found that CXCL1 and MCP-1 concentrations were significantly elevated, suggesting their potential role in canine stroke and future research targets.
Introduction: Neuroinflammation that occurs in the brain after stroke has been shown to be important to disease pathogenesis and outcomes. The aim of this study was to evaluate a large number of pro- and anti-inflammatory cytokines in dogs with clinically-confirmed, naturally occurring stroke. Materials and methods: Fifteen dogs with a clinical diagnosis of ischemic stroke and ten healthy control dogs were included in the study. Amultiplex immunoassay was utilized to evaluate cerebrospinal fluid for GM-CSF, IFN-gamma, IL-2, IL-4, IL-6, IL-7, IL-8, IL-10, IL-15, IL-18, IP-10, CXCL1, MCP-1, and TNF-alpha. Results: Mean concentrations of CXCL1 (stroke-436 pg/ml, control-267 pg/ml, p = 0.01) and MCP-1 (stroke-196 pg/ml, control-66 pg/ml, p = 0.0001) were significantly elevated in dogs with stroke when compared with control dogs. Location and type of infarct, duration of clinical signs, and use of anti-inflammatory medications were not associated with differences in cytokine concentration. Discussion: CXCL1 and MCP-1 may play a role in naturally occurring canine stroke and represent targets for future research.
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