☆ 4.7 Article

Lactate is useful for the efficient replication of porcine epidemic diarrhea virus in cell culture

FRONTIERS IN VETERINARY SCIENCE (2023)

Related references

Note: Only part of the references are listed.

Article Immunology

The Interferon Response Dampens the Usutu Virus Infection-Associated Increase in Glycolysis

Maria Elisabeth Wald et al.

Summary: The study found that USUV infection significantly increase glycolytic activity in cells and inhibit the metabolic potential of glycolysis, contributing to production of virus progeny. The results also suggest that the type I and type III IFN system are determinants for human host cell permissiveness to USUV infection.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

Add to Collection

Article Microbiology

Metabolomic Profiling Reveals New Insight of Fowl Adenovirus Serotype 4 Infection

Haiying Ma et al.

Summary: A study found that highly pathogenic fowl adenovirus serotype 4 (FAdV-4) infection can restore the metabolic networks in host cells, and host cell metabolism plays an important role in virus replication. Furthermore, the production of the virus was significantly reduced when the host cells were cultured in glucose or glutamine-deficient conditions.

FRONTIERS IN MICROBIOLOGY (2022)

Add to Collection

Article Biology

Multi-omics insights into host-viral response and pathogenesis in Crimean-Congo hemorrhagic fever viruses for novel therapeutic target

Ujjwal Neogi et al.

Summary: Through system biology analysis of CCHF patients and cell infection models, this study found that CCHFV infection causes host metabolic reprogramming and negative coordination with biological signaling systems. Blocking key metabolic pathways can inhibit viral replication. Interferon-mediated antiviral mechanisms play an important role at the system level and during viral replication.

ELIFE (2022)

Add to Collection

Article Microbiology

Singapore Grouper Iridovirus Induces Glucose Metabolism in Infected Cells by Activation of Mammalian Target of Rapamycin Signaling

Xixi Guo et al.

Summary: This study reveals the essential role of glucose metabolism and mTOR in SGIV infection and provides new insights into the pathogenesis of iridovirus.

FRONTIERS IN MICROBIOLOGY (2022)

Add to Collection

Review Medicine, Research & Experimental

Host cell glutamine metabolism as a potential antiviral target

Sandro Massao Hirabara et al.

Summary: Viruses consist of a nucleic acid genome and a protein coat, with enveloped viruses having a lipid bilayer membrane. Virus-infected host cells show increased glutamine utilization and metabolism, which is essential for energy production and synthesis of macromolecules necessary for virus assembly.

CLINICAL SCIENCE (2021)

Add to Collection

Article Multidisciplinary Sciences

Hepatitis B virus rigs the cellular metabolome to avoid innate immune recognition

Li Zhou et al.

Summary: Glucose metabolism and innate immunity have co-evolved, but the mechanisms of interaction during HBV infection remain unclear. This study shows that HBV can inhibit RIG-I/MAVS signaling pathway by enhancing glycolysis and lactate production, leading to immune evasion. Lactate binds MAVS, preventing its mitochondrial localization and interfering with antiviral immune response to HBV.

NATURE COMMUNICATIONS (2021)

Add to Collection

Article Immunology

Metabolomics Exploration of Pseudorabies Virus Reprogramming Metabolic Profiles of PK-15 Cells to Enhance Viral Replication

Hongchao Gou et al.

Summary: Metabolomics has shown promise in uncovering the complex mechanisms of virus-host interactions, as demonstrated in a study exploring the metabolic networks in PK-15 cells infected with different PRV strains. The reprogramming of metabolic activities in PK-15 cells by PRV was crucial for enhancing viral replication, particularly through the metabolic flux from glycolysis, PPP, and glutamine metabolism to nucleotide biosynthesis.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

Add to Collection

Article Multidisciplinary Sciences

Influenza A induces lactate formation to inhibit type I IFN in primary human airway epithelium

Jacob Thyrsted et al.

Summary: In this study, the researchers demonstrated that both Influenza A virus (IAV) and severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) induce distinct metabolic changes in human airway epithelium, with lactate dehydrogenase A (LDHA) playing a key role in regulating type I interferon responses and promoting IAV replication. The findings suggest that LDHA and lactate promote IAV replication by inhibiting MAVS-dependent induction of type I IFN in primary human airway epithelium, highlighting a potential target for future antiviral strategies.

ISCIENCE (2021)

Add to Collection

Article Medicine, Research & Experimental

Glycolysis downregulation is a hallmark of HIV-1 latency and sensitizes infected cells to oxidative stress

Iart Luca Shytaj et al.

Summary: The study reveals that latent HIV-1 infection downregulates glycolysis and relies on the pentose phosphate pathway for maintaining latency. Reactivation of the virus can revert this effect and decrease proviral DNA in infected cells.

EMBO MOLECULAR MEDICINE (2021)

Add to Collection

Article Multidisciplinary Sciences

Proteomics of SARS-CoV-2-infected host cells reveals therapy targets

Denisa Bojkova et al.

NATURE (2020)

Add to Collection

Review Immunology

Efficacy of Porcine Epidemic Diarrhea Vaccines: A Systematic Review and Meta-Analysis

Hokeun Won et al.

VACCINES (2020)

Add to Collection

Article Virology

Metabolic reprogramming as a feast for virus replication

K. Polcicova et al.

ACTA VIROLOGICA (2020)

Add to Collection

Article Microbiology

Glycolysis Is an Intrinsic Factor for Optimal Replication of a Norovirus

Karla D. Passalacqua et al.

MBIO (2019)

Add to Collection

Article Biotechnology & Applied Microbiology

Investigation of cell culture conditions for optimal foot-and-mouth disease virus production

Veronika Dill et al.

BMC BIOTECHNOLOGY (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS

Weina Zhang et al.

CELL (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Lipidomic Profiling Reveals Significant Perturbations of Intracellular Lipid Homeostasis in Enterovirus-Infected Cells

Bingpeng Yan et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Add to Collection

Article Virology

A newly isolated Chinese virulent genotype GIIb porcine epidemic diarrhea virus strain: Biological characteristics, pathogenicity and immune protective effects as an inactivated vaccine candidate

Xinsheng Liu et al.

VIRUS RESEARCH (2019)

Add to Collection

Review Biochemistry & Molecular Biology

Including the mitochondrial metabolism of L-lactate in cancer metabolic reprogramming

Lidia de Bari et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2018)

Add to Collection

Article Biotechnology & Applied Microbiology

Vaccination of sows with a dendritic cell-targeted porcine epidemic diarrhea virus S1 protein-based candidate vaccine reduced viral shedding but exacerbated gross pathological lesions in suckling neonatal piglets

Sakthivel Subramaniam et al.

JOURNAL OF GENERAL VIROLOGY (2018)

Add to Collection

Article Virology

Rubella Viruses Shift Cellular Bioenergetics to a More Oxidative and Glycolytic Phenotype with a Strain-Specific Requirement for Glutamine

Nicole C. Bilz et al.

JOURNAL OF VIROLOGY (2018)

Add to Collection

Review Infectious Diseases

Swine enteric coronavirus disease: A review of 4years with porcine epidemic diarrhoea virus and porcine deltacoronavirus in the United States and Canada

M. C. Niederwerder et al.

TRANSBOUNDARY AND EMERGING DISEASES (2018)

Add to Collection

Article Virology

Efficacy of genogroup 1 based porcine epidemic diarrhea live vaccine against genogroup 2 field strain in Japan

Tetsuo Sato et al.

VIROLOGY JOURNAL (2018)

Add to Collection

Article Virology

Porcine epidemic diarrhea in China

Dang Wang et al.

VIRUS RESEARCH (2016)

Add to Collection

Article Veterinary Sciences

An inactivated vaccine made from a US field isolate of porcine epidemic disease virus is immunogenic in pigs as demonstrated by a dose-titration

Emily A. Collin et al.

BMC VETERINARY RESEARCH (2015)

Add to Collection

Article Virology

Dengue Virus Induces and Requires Glycolysis for Optimal Replication

Krystal A. Fontaine et al.

JOURNAL OF VIROLOGY (2015)

Add to Collection

Review Immunology

Porcine epidemic diarrhea: a review of current epidemiology and available vaccines

Daesub Song et al.

CLINICAL AND EXPERIMENTAL VACCINE RESEARCH (2015)

Add to Collection

Article Cell Biology

Adenovirus E4ORF1-Induced MYC Activation Promotes Host Cell Anabolic Glucose Metabolism and Virus Replication

Minh Thai et al.

CELL METABOLISM (2014)

Add to Collection

Article Virology

Vaccinia Virus Requires Glutamine but Not Glucose for Efficient Replication

Krystal A. Fontaine et al.

JOURNAL OF VIROLOGY (2014)

Add to Collection

© Peeref 2019-2024. All rights reserved.