Journal
FRONTIERS IN VETERINARY SCIENCE
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fvets.2023.1117313
Keywords
anesthesia; gabapentin; minimum alveolar concentration (MAC); isoflurane; cat
Categories
Ask authors/readers for more resources
The objective of this study was to determine if oral gabapentin decreases the minimum alveolar concentration (MAC) of isoflurane in cats. The results showed that gabapentin significantly reduced the MAC of isoflurane in cats without affecting cardiovascular and other vital variables.
ObjectiveTo determine if oral gabapentin decreases the minimum alveolar concentration (MAC) of isoflurane in cats. Study designProspective, randomized, blinded, crossover, and experimental study. AnimalsA total of six healthy adult cats (three male, three female) aged 18-42 months, weighing 3.31 +/- 0.26 kg. MethodsCats were randomly given oral gabapentin (100 mg cat(-1)) or placebo 2 h before starting MAC determination, with the crossover treatment given at least 7 days apart. Anesthesia was induced and maintained with isoflurane in oxygen. Isoflurane MAC was determined in duplicate using an iterative bracketing technique and tail clamp method. Hemodynamic and other vital variables were recorded at each stable isoflurane concentration and were compared between gabapentin and placebo treatments at lowest end-tidal isoflurane concentration when cats did not respond to tail clamping. A paired t-test was used to compare normally distributed data, and a Wilcoxon signed-rank test was applied for non-normally distributed data. Significance was set at p < 0.05. Data are mean +/- standard deviation. ResultsIsoflurane MAC in the gabapentin treatment was 1.02 +/- 0.11%, which was significantly lower than that in the placebo treatment (1.49 +/- 0.12%; p < 0.001), decreasing by 31.58 +/- 6.94%. No significant differences were found in cardiovascular and other vital variables between treatments.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available