[18F]FES PET Resolves the Diagnostic Dilemma of COVID-19-Vaccine-Associated Hypermetabolic Lymphadenopathy in ER-Positive Breast Cancer

Article Radiology, Nuclear Medicine & Medical Imaging

Absolute Lymphocyte Count After COVID-19 Vaccination Is Associated with Vaccine-Induced Hypermetabolic Lymph Nodes on 18F-FDG PET/CT: A Focus in Breast Cancer Care

Romain-David Seban et al.

Summary: Patients with a normal ALC after COVID-19 vaccination were more likely to have v-HLNs on F-18-FDG PET/CT, which might be associated with a stronger immune response to vaccination.

JOURNAL OF NUCLEAR MEDICINE (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

COVID-19 mRNA Vaccination: Age and Immune Status and Its Association with Axillary Lymph Node PET/CT Uptake

Michal Eifer et al.

Summary: After receiving COVID-19 mRNA vaccination, a significant proportion of patients showed uptake in the ipsilateral axillary lymph nodes, which was more common in immunocompetent patients.

JOURNAL OF NUCLEAR MEDICINE (2022)

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Editorial Material Radiology, Nuclear Medicine & Medical Imaging

DOTATATE Uptake in an Axillary Lymph Node After COVID-19 Vaccination

James Brophy et al.

Summary: This report presents a case of DOTATATE PET-avid axillary lymph node following injection of the Johnson & Johnson COVID-19 vaccine. Recent data have shown increased metabolic activity in lymph nodes after COVID-19 vaccination.

CLINICAL NUCLEAR MEDICINE (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

[18F]FDG uptake of axillary lymph nodes after COVID-19 vaccination in oncological PET/CT: frequency, intensity, and potential clinical impact

Stephan Skawran et al.

Summary: FDG-avid axillary lymph nodes are common after COVID-19 vaccination, with a higher frequency observed in patients who received the Moderna vaccine compared to the Pfizer-BioNTech vaccine. Clinical management was affected in some cases due to the presence of FDG-avid lymph nodes.

EUROPEAN RADIOLOGY (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Vaccine-Related Lymph Nodes The Emerging Pitfalls of 18F-Fluorocholine and 68Ga-PSMA-11 PET/CT in the Era of COVID-19 Vaccination

Loic Ah-Thiane et al.

Summary: This study evaluated the incidence and characteristics of lymph nodes related to COVID-19 vaccination on PET/CT using different radiopharmaceuticals. The results showed that the incidence of vaccine-related axillary and supraclavicular lymph nodes varied with different radiopharmaceuticals. Factors such as the nature of the radiopharmaceutical, the number of vaccine doses received, the time interval between vaccination and PET/CT, and the prostate-specific antigen level were associated with the detection of vaccine-related lymph nodes.

CLINICAL NUCLEAR MEDICINE (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Novel68Ga-FAPI PET/CT offers oncologic staging without COVID-19 vaccine-related pitfalls

Tristan T. Demmert et al.

JOURNAL OF NUCLEAR MEDICINE (2022)

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Review Radiology, Nuclear Medicine & Medical Imaging

Recent topics of the clinical utility of PET/MRI in oncology and neuroscience

Yuji Nakamoto et al.

Summary: This article reviews recent studies on PET/MRI, highlighting the diagnostic performance of FDG in oncology and the potential of PSMA PET/MRI for determining biopsy sites. The article also discusses the clinical application of artificial intelligence in PET/MRI imaging and the role of PET/MRI in neuroscience.

ANNALS OF NUCLEAR MEDICINE (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Axillary lymph node characteristics in breast cancer patients versus post-COVID-19 vaccination: Overview of current evidence per imaging modality

T. J. A. van Nijnatten et al.

Summary: The characteristics of axillary lymph nodes may differ between breast cancer diagnosis and post-COVID-19 vaccination. Clinical information regarding injection site, vaccine type, and vaccination date should be documented to improve interpretation and guide treatment.

EUROPEAN JOURNAL OF RADIOLOGY (2022)

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Article Medicine, General & Internal

Hypermetabolic Ipsilateral Supraclavicular and Axillary Lymphadenopathy: Optimal Time Point for Performing an 18F-FDG PET/CT after COVID-19 Vaccination

Kwadwo Antwi et al.

Summary: The study aimed to assess the incidence of vaccine-related hypermetabolic lymphadenopathy (HLA) in patients with SARS-CoV2 vaccination and determine the optimal timing for F-18-FDG PET/CT. The results showed that FDG PET should be postponed by at least 3 weeks after vaccination, especially when evaluating axillary status accurately.

DIAGNOSTICS (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

FDG PET/CT radiomics as a tool to differentiate between reactive axillary lymphadenopathy following COVID-19 vaccination and metastatic breast cancer axillary lymphadenopathy: a pilot study

Michal Eifer et al.

Summary: The study aimed to differentiate between FDG-avid breast cancer metastatic lymphadenopathy and FDG-avid COVID-19 mRNA vaccine-related axillary lymphadenopathy using machine learning and radiomics. The results demonstrated that radiomics features can effectively differentiate between the two conditions, which may have clinical significance in distinguishing between benign and malignant lymph nodes.

EUROPEAN RADIOLOGY (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

COVID-19 vaccine-related unilateral axillary lymphadenopathy: Pattern on screening breast MRI allowing for a benign assessment

Michael J. Plaza et al.

CLINICAL IMAGING (2021)

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Editorial Material Radiology, Nuclear Medicine & Medical Imaging

COVID-19 vaccination induced axillary nodal uptake on [18F]FDG PET/CT

Ayah Adel Nawwar et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2021)

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Editorial Material Radiology, Nuclear Medicine & Medical Imaging

Imaging of COVID-19 Vaccination at FDG PET/CT

Michal Eifer et al.

RADIOLOGY (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Frequency and Characteristics of Nodal and Deltoid FDG and 11C-Choline Uptake on PET Performed After COVID-19 Vaccination

Dane G. Schroeder et al.

Summary: This study aimed to evaluate the frequency and characteristics of abnormal FDG and C-11-choline uptake on PET performed after COVID-19 vaccination. The results showed occasional increased axillary lymph node or ipsilateral deltoid uptake on FDG or C-11-choline PET after vaccination with the Pfizer-BioNTech or Moderna vaccine. Physicians interpreting PET findings after COVID-19 vaccination should be aware of these characteristics to guide appropriate follow-up management and avoid unnecessary biopsies.

AMERICAN JOURNAL OF ROENTGENOLOGY (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Hypermetabolic lymphadenopathy following administration of BNT162b2 mRNA Covid-19 vaccine: incidence assessed by [18F]FDG PET-CT and relevance to study interpretation

Dan Cohen et al.

Summary: The study investigated the incidence of VAHL after BNT162b2 vaccination and its relevance to PET-CT interpretation in oncologic patients. VAHL was found to be more common and with higher intensity following the booster dose of the vaccine. It is recommended to schedule PET-CT scans during time intervals with lower incidence of VAHL to avoid false or equivocal reports in oncology patients.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Prevalence of Increased FDG PET/CT Axillary Lymph Node Uptake Beyond 6 Weeks after mRNA COVID-19 Vaccination

Yael Eshet et al.

RADIOLOGY (2021)

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Editorial Material Medicine, General & Internal

Immune Response Visualized In Vivo by [18F]-FDG PET/CT after COVID-19 Vaccine

Romain-David Seban et al.

Summary: The deployment of COVID-19 vaccines worldwide has led to immune activation, as evidenced by FDG-avid axillary lymph nodes and increased spleen glucose metabolism, reflecting regional and systemic immune responses. These findings suggest that immune response may be associated with increased glucose metabolism in lymphoid organs, emphasizing the importance for nuclear physicians to recognize such immune responses post-vaccination.

DIAGNOSTICS (2021)

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Review Oncology