Microwave Radiometry for the Diagnosis and Monitoring of Inflammatory Arthritis

The ability of microwave radiometry (MWR) to detect with high accuracy in-depth temperature changes in human tissues is under investigation in various medical fields. The need for non-invasive, easily accessible imaging biomarkers for the diagnosis and monitoring of inflammatory arthritis provides the background for this application in order to detect the local temperature increase due to the inflammatory process by placing the appropriate MWR sensor on the skin over the joint. Indeed, a number of studies reviewed herein have reported interesting results, suggesting that MWR is useful for the differential diagnosis of arthritis as well as for the assessment of clinical and subclinical inflammation at the individual large or small joint level and the patient level. MWR showed higher agreement with musculoskeletal ultrasound, used as a reference, than with clinical examination in rheumatoid arthritis (RA), while it also appeared useful for the assessment of back pain and sacroiliitis. Further studies with a larger number of patients are warranted to confirm these findings, taking into account the current limitations of the available MWR devices. This may lead to the production of easily accessible and inexpensive MWR devices that will provide a powerful impetus for personalized medicine.

Automated summary

The ability of microwave radiometry (MWR) to accurately detect in-depth temperature changes in human tissues is being investigated for its application in the diagnosis and monitoring of inflammatory arthritis. Studies have shown promising results, suggesting that MWR can be a useful tool for the differential diagnosis of arthritis and for assessing inflammation at both joint and patient levels. However, further studies with larger patient populations are needed to confirm these findings and overcome the current limitations of MWR devices.