Journal
DIAGNOSTICS
Volume 13, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/diagnostics13111871
Keywords
PET; MRI; image reconstruction; fluorodeoxyglucose; Bayesian penalised likelihood; whole-body imaging; abbreviated MRI
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This study evaluated the diagnostic value of a rapid whole-body FDG PET/MRI approach, combining BPL PET with an optimised beta value and abb-MRI. The study compared its diagnostic performance with standard PET/MRI that uses OSEM PET and std-MRI. Clinical evaluations and assessments were conducted in patients, and the results showed that the combined BPL/abb-MRI approach achieved rapid whole-body PET/MRI in <= 1.5 min per bed position while maintaining comparable diagnostic performance to standard PET/MRI.
This study evaluated the diagnostic value of a rapid whole-body fluorodeoxyglucose (FDG) positron emission tomography (PET)/magnetic resonance imaging (MRI) approach, combining Bayesian penalised likelihood (BPL) PET with an optimised beta value and abbreviated MRI (abb-MRI). The study compares the diagnostic performance of this approach with the standard PET/MRI that utilises ordered subsets expectation maximisation (OSEM) PET and standard MRI (std-MRI). The optimal beta value was determined by evaluating the noise-equivalent count (NEC) phantom, background variability, contrast recovery, recovery coefficient, and visual scores (VS) for OSEM and BPL with beta 100-1000 at 2.5-, 1.5-, and 1.0-min scans, respectively. Clinical evaluations were conducted for NECpatient, NECdensity, liver signal-to-noise ratio (SNR), lesion maximum standardised uptake value, lesion signal-to-background ratio, lesion SNR, and VS in 49 patients. The diagnostic performance of BPL/abb-MRI was retrospectively assessed for lesion detection and differentiation in 156 patients using VS. The optimal beta values were beta 600 for a 1.5-min scan and beta 700 for a 1.0-min scan. BPL/abb-MRI at these beta values was equivalent to OSEM/std-MRI for a 2.5-min scan. By combining BPL with optimal beta and abb-MRI, rapid whole-body PET/MRI could be achieved in <= 1.5 min per bed position, while maintaining comparable diagnostic performance to standard PET/MRI.
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