Journal
DIAGNOSTICS
Volume 13, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/diagnostics13061164
Keywords
vertebral metastases; spine stability; radiofrequency ablation; thermal ablation; vertebroplasty; kyphoplasty
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Vertebral body metastases (VBM) are a common site of bone metastasis, and the treatment management presents challenges. Radiofrequency ablation (RFA) is a potential alternative, but it may affect the biomechanics and microanatomy of the vertebral body, increasing the risk of fractures and instability. This study aims to investigate the impact of RFA on spine stability.
Vertebral body metastases (VBM) are one of the most frequent sites of bone metastasis, and their adequate therapeutic management still represents an insidious challenge for both oncologists and surgeons. A possible alternative treatment for VBM is radiofrequency ablation (RFA), a percutaneous technique in which an alternating current is delivered to the tumor lesion producing local heating and consequent necrosis. However, RFA alone could alter the biomechanics and microanatomy of the vertebral body, thus increasing the risk of post-procedure vertebral fractures and spine instability, and indeed the aim of the present study is to investigate the effects of RFA on spine stability. A systematic review according to PRISMA-P guidelines was performed, and 17 papers were selected for the systematic review. The results show how RFA is an effective, safe, and feasible alternative to conventional radiotherapy for the treatment of VBM without indication for surgery, but spine stability is a major issue in this context. Although exerting undeniable benefits on pain control and local tumor recurrence, RFA alone increases the risk of spine instability and consequent vertebral body fractures and collapses. Concomitant safe and feasible therapeutic strategies such as percutaneous vertebroplasty and kyphoplasty have shown synergic positive effects on back pain and improvement in spine stability.
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