4.6 Article

KRAS Mutational Profiles among Colorectal Cancer Patients in the East Coast of Peninsular Malaysia

Related references

Note: Only part of the references are listed.
Article Oncology

Sotorasib for previously treated colorectal cancers with KRASG12C mutation (CodeBreaK100): a prespecified analysis of a single-arm, phase 2 trial

Marwan G. Fakih et al.

Summary: Sotorasib, a specific inhibitor of KRAS(G12C) protein, showed modest anti-tumour activity and manageable safety in heavily pretreated patients with colorectal cancer in a phase 2 trial. The overall response rate of 9.7% did not reach the benchmark, but sotorasib is being evaluated in combination with other therapeutics to enhance potential activity and address potential resistance mechanisms.

LANCET ONCOLOGY (2022)

Article Oncology

Dietary Risk Factors and Odds of Colorectal Adenoma in Malaysia: A Case Control Study

Razinah Sharif et al.

Summary: Current evidence suggests that dietary and lifestyle factors may play an important role in colorectal cancer risk. A case-control study at Hospital Canselor Tuanku Muhriz UKM in Malaysia found that male gender, smoking, family history of cancer, high body fat percentage, high calorie and fat intake, and red meat intake over 100g per day increased the risk of colorectal adenomas (CRA). Conversely, high fiber and calcium intake were found to decrease CRA risk. These modifiable risk factors could be targeted for lifestyle interventions to reduce CRA risk.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2022)

Article Oncology

KRAS-G12C Mutation in One Real-Life and Three Population-Based Nordic Cohorts of Metastatic Colorectal Cancer

Emerik Osterlund et al.

Summary: This study examines the frequency and clinical characteristics of KRAS-G12C mutation in metastatic colorectal cancer patients and compares it to other KRAS mutations. The results show that there are no significant differences in patient characteristics and outcomes between patients with KRAS-G12C tumors and those with other KRAS mutations. This contradicts previous studies that claimed differences in many aspects, often with worse outcomes for those with a KRAS-G12C mutation, although the results were not consistent.

FRONTIERS IN ONCOLOGY (2022)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Review Medicine, Research & Experimental

The current understanding on the impact of KRAS on colorectal cancer

Mingjing Meng et al.

Summary: KRAS mutations are a major driver in CRC and significantly impact the prognosis and survival of patients. Research studies focus on exploring potential therapeutics for KRAS mutant CRC, as well as understanding the pathological consequences and treatment response of these mutations. Challenges and difficulties in treating KRAS mutant CRC are also discussed.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Article Oncology

Serum Tumor Markers Combined With Clinicopathological Characteristics for Predicting MMR and KRAS Status in 2279 Chinese Colorectal Cancer Patients: A Retrospective Analysis

Ning Zhao et al.

Summary: The study found that serum tumor markers and clinicopathological characteristics were significantly associated with the status of KRAS and MMR. The combination of these two factors had a strong predictive power for KRAS mutations and dMMR among colorectal cancer patients.

FRONTIERS IN ONCOLOGY (2021)

Article Surgery

Metastatic Profile of Colorectal Cancer: Interplay Between Primary Tumor Location and KRAS Status

Zachary Zihui Yong et al.

JOURNAL OF SURGICAL RESEARCH (2020)

Review Oncology

Targeting the MAPK Pathway in KRAS-Driven Tumors

Matthias Drosten et al.

CANCER CELL (2020)

Article Gastroenterology & Hepatology

Impact of primary colorectal Cancer location on the KRAS status and its prognostic value

Ming-zhi Xie et al.

BMC GASTROENTEROLOGY (2019)

Article Gastroenterology & Hepatology

G12V and G12C mutations in the gene KRAS are associated with a poorer prognosis in primary colorectal cancer

Tamuro Hayama et al.

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE (2019)

Review Gastroenterology & Hepatology

Update on Sporadic Colorectal Cancer Genetics

Karin M. Hardiman

CLINICS IN COLON AND RECTAL SURGERY (2018)

Review Biochemistry & Molecular Biology

Are Colon and Rectal Cancer Two Different Tumor Entities? A Proposal to Abandon the Term Colorectal Cancer

Stephan Paschke et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Review Gastroenterology & Hepatology

Difference Between Left-Sided and Right-Sided Colorectal Cancer: A Focused Review of Literature

Burcin Baran et al.

GASTROENTEROLOGY RESEARCH (2018)

Article Gastroenterology & Hepatology

Global patterns and trends in colorectal cancer incidence and mortality

Melina Arnold et al.

Article Gastroenterology & Hepatology

Missense Mutations in MLH1, MSH2, KRAS, and APC Genes in Colorectal Cancer Patients in Malaysia

Nor Azian Abdul Murad et al.

DIGESTIVE DISEASES AND SCIENCES (2012)

Article Pathology

Sanger sequencing in routine KRAS testing: a review of 1720 cases from a pathologist's perspective

Umberto Malapelle et al.

JOURNAL OF CLINICAL PATHOLOGY (2012)

Letter Oncology

Mutations of KRAS and BRAF in primary and matched metastatic sites of colorectal cancer

Salvatore Artale et al.

JOURNAL OF CLINICAL ONCOLOGY (2008)

Review Oncology

The MAPK signalling pathways and colorectal cancer

JY Fang et al.

LANCET ONCOLOGY (2005)

Article Oncology

Kirsten ras mutations in patients with colorectal cancer:: the 'RASCAL II' study

HJN Andreyev et al.

BRITISH JOURNAL OF CANCER (2001)