4.6 Review

Impaired Intestinal Permeability Assessed by Confocal Laser Endomicroscopy-A New Potential Therapeutic Target in Inflammatory Bowel Disease

Related references

Note: Only part of the references are listed.
Article Gastroenterology & Hepatology

Intestinal Barrier Healing Is Superior to Endoscopic and Histologic Remission for Predicting Major Adverse Outcomes in Inflammatory Bowel Disease: The Prospective ERIca Trial

Timo Rath et al.

Summary: In this study, the predictive value of endoscopic and histologic remission for long-term disease behavior in patients with inflammatory bowel diseases (IBD) was compared. The results showed that barrier healing was superior to endoscopic and histologic remission in predicting long-term disease progression. Therefore, barrier healing may be considered as a potential treatment target in future clinical trials.

GASTROENTEROLOGY (2023)

Review Immunology

The Gut Microbiota in Inflammatory Bowel Disease

Peng Qiu et al.

Summary: Crohn's disease and ulcerative colitis are two main forms of inflammatory bowel disease (IBD), and intestinal microorganisms play a key role in the development and maintenance of these diseases. However, the specific causes of IBD are still unclear, and it is unknown whether a single transmissible agent is involved. Changes in the bacterial communities in the gut may be due to inflammatory reactions and tissue destruction, rather than causing the disease itself. Antibiotic therapy has generally been ineffective in treating IBD, but recent studies suggest that manipulating the gut microbiota and interacting with the gut immune system through probiotics, prebiotics, and synbiotics may hold potential in controlling these diseases.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

Article Medicine, General & Internal

Immigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native Patients

Ana Gutierrez et al.

Summary: Compared with native-born patients, first-generation-immigrant IBD patients in Spain show differences in disease onset age, extraintestinal manifestations, and biologics usage.

FRONTIERS IN MEDICINE (2022)

Article Gastroenterology & Hepatology

Plasma and fecal zonulin are not altered by a high green leafy vegetable dietary intervention: secondary analysis of a randomized control crossover trial

Aaron J. Riviere et al.

Summary: A high green leafy vegetable (GLV) diet intervention increased serum zonulin levels and had no effect on fecal zonulin. Lack of concordance between several inflammation-associated biomarkers and zonulin corroborate recent reports of limited utility of zonulin in obese adults free of lower gastrointestinal disease.

BMC GASTROENTEROLOGY (2022)

Review Gastroenterology & Hepatology

The epidemiology of inflammatory bowel disease in Asia and Asian immigrants to Western countries

Satimai Aniwan et al.

Summary: The incidence and prevalence of inflammatory bowel disease (IBD) are rapidly increasing in Asia and among Asian immigrants. This population exhibits unique disease phenotypes in terms of gender predominance and complications.

UNITED EUROPEAN GASTROENTEROLOGY JOURNAL (2022)

Review Nutrition & Dietetics

Dietary Patterns and Gut Microbiota Changes in Inflammatory Bowel Disease: Current Insights and Future Challenges

Jing Yan et al.

Summary: Diet plays a crucial role in regulating gut microbiota and the course of inflammatory bowel disease (IBD), with certain dietary patterns found to be effective in achieving clinical remission of IBD.

NUTRIENTS (2022)

Review Gastroenterology & Hepatology

Confocal laser endomicroscopy in gastro-intestinal endoscopy: technical aspects and clinical applications

Nastazja Dagny Pilonis et al.

Summary: Confocal laser endomicroscopy (CLE) is an advanced endoscopic imaging technology that provides a magnified, cellular level view of gastrointestinal epithelia. It has moderate to high diagnostic accuracy for neoplastic and inflammatory conditions through the gastrointestinal tract. CLE can resolve diagnostic dilemmas in cases where conventional imaging fails and reduce the need for extensive tissue sampling. However, limitations include a narrow field of view, high capital costs, and specialized operator training requirements.

TRANSLATIONAL GASTROENTEROLOGY AND HEPATOLOGY (2022)

Review Gastroenterology & Hepatology

The endoscopic diagnosis of mucosal healing and deep remission in inflammatory bowel disease

Kentaro Moriichi et al.

Summary: In patients with inflammatory bowel disease, the goals of treatment have shifted towards achieving mucosal healing and deep remission. However, the definition of mucosal healing remains controversial, and new endoscopic procedures may help to assess these goals more accurately in the future. Molecular imaging also has the potential to detect factors associated with deep remission.

DIGESTIVE ENDOSCOPY (2021)

Article Gastroenterology & Hepatology

Risk of Relapse in Patients With Ulcerative Colitis With Persistent Endoscopic Healing: A Durable Treatment Endpoint

Sushrut Jangi et al.

Summary: Patients with active UC treated-to-target of clinical remission, who achieve and maintain symptomatic remission and EH over consecutive endoscopies, have a low risk of relapse, particularly in a subset of patients who simultaneously achieve histological remission. Therefore, persistent EH may be an important indicator of deep remission.

JOURNAL OF CROHNS & COLITIS (2021)

Review Gastroenterology & Hepatology

Endoscopic imaging in inflammatory bowel disease: current developments and emerging strategies

Jouke J. H. Van der Laan et al.

Summary: Advancements in enhanced and magnified endoscopy have improved assessment of ileocolonic mucosa in IBD. Implementing molecular imaging in endoscopy could help overcome clinical challenges by providing real-time in vivo view of targeted biomarkers. Label-free modalities may optimize mucosal healing and dysplasia detection in IBD patients.

EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY (2021)

Article Gastroenterology & Hepatology

STRIDE-II: An Update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) Initiative of the International Organization for the Study of IBD (IOIBD): Determining Therapeutic Goals for Treat-to-Target strategies in IBD

Dan Turner et al.

Summary: STRIDE-II presents treatment targets for both adult and pediatric IBD, including long-term and short-term goals. These targets cover aspects such as clinical response, endoscopic healing, quality of life, and growth, providing guidance for improving patient outcomes.

GASTROENTEROLOGY (2021)

Article Gastroenterology & Hepatology

Biomarkers for assessment of intestinal permeability in clinical practice

Benjamin Seethaler et al.

Summary: Biomarkers from blood and fecal samples are associated with established tests of intestinal permeability, suggesting their potential use in assessing gut barrier function in prospective cohort studies and large-scale clinical trials where tracer-based tests may not be feasible. Plasma LBP is identified as a promising biomarker for intestinal permeability in adults, while fecal zonulin shows potential as a biomarker in overweight and obese individuals.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2021)

Article Gastroenterology & Hepatology

Development and Validation of Test for Leaky Gut Small Intestinal and Colonic Permeability Using Sugars in Healthy Adults

Katayoun Khoshbin et al.

Summary: This study aimed to obtain normative data on small intestinal and colonic permeability. Results showed that C-13-mannitol is the preferred probe for small intestinal permeability, while C-12-mannitol is not suitable for use.

GASTROENTEROLOGY (2021)

Article Microbiology

Regulation of the gut barrier by carbohydrates from diet - Underlying mechanisms and possible clinical implications

Stephan C. Bischoff et al.

Summary: The gut barrier is considered relevant in the pathogenesis of various diseases, but its regulation, especially involving food components and gut microbiota, is poorly understood. Further research is needed to clarify the role of these factors in gut barrier function and disease development.

INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY (2021)

Review Gastroenterology & Hepatology

Evolving role of endoscopy in inflammatory bowel disease: Going beyond diagnosis

Paulina Nunez et al.

Summary: Endoscopic evaluation plays a crucial role in predicting disease activity and severity in inflammatory bowel diseases, with mucosal healing associated with improved clinical outcomes and incorporated into standard care. Therapeutic endoscopic options and surveillance strategies, including early detection of neoplasia, continue to advance with evolving technology and visualization techniques.

WORLD JOURNAL OF GASTROENTEROLOGY (2021)

Article Nutrition & Dietetics

Gut Microbiota Differences According to Ultra-Processed Food Consumption in a Spanish Population

Amanda Cuevas-Sierra et al.

Summary: The consumption of ultra-processed foods (UPFs) may have varying effects on gut microbiota composition in women and men, leading to changes in the abundance of certain bacteria. This study highlights the importance of considering sex differences in the impact of UPFs on microbiota diversity and profile.

NUTRIENTS (2021)

Review Nutrition & Dietetics

The Role of Intestinal Permeability in Gastrointestinal Disorders and Current Methods of Evaluation

Tim Vanuytsel et al.

Summary: Intestinal permeability plays a crucial role in various gastrointestinal and non-gastrointestinal disorders, with evidence showing its importance in conditions like celiac disease and inflammatory bowel disease. While ex vivo techniques remain the gold standard for assessing epithelial barrier function, in vivo techniques, despite their limitations, are widely used in research and clinical practice.

FRONTIERS IN NUTRITION (2021)

Review Gastroenterology & Hepatology

Artificial intelligence in gastrointestinal endoscopy for inflammatory bowel disease: a systematic review and new horizons

Gian Eugenio Tontini et al.

Summary: AI-assisted endoscopy in the field of IBD is a rapidly growing research area with promising technical results, showing potential to enhance patient management in clinical practice and gastrointestinal endoscopy. Additional confirmation from real-life clinical settings is needed to validate the benefits of AI in assessing UC mucosal activity and CD capsule endoscopy.

THERAPEUTIC ADVANCES IN GASTROENTEROLOGY (2021)

Review Gastroenterology & Hepatology

Nutrition in Inflammatory Bowel Disease

Philipp Schreiner et al.

DIGESTION (2020)

Article Surgery

SAGES TAVAC safety and efficacy analysis WATS3D(CDx Diagnostics, Suffern, NY)

Salvatore Docimo et al.

SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES (2020)

Article Cell Biology

Dietary simple sugars alter microbial ecology in the gut and promote colitis in mice

Shahanshah Khan et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

Review Gastroenterology & Hepatology

Novel Imaging Approaches in Inflammatory Bowel Diseases

Parakkal Deepak et al.

INFLAMMATORY BOWEL DISEASES (2019)

Article Gastroenterology & Hepatology

ECCO-ESGAR Guideline for Diagnostic Assessment in IBD Part 2: IBD scores and general principles and technical aspects

Andreas Sturm et al.

JOURNAL OF CROHNS & COLITIS (2019)

Article Gastroenterology & Hepatology

Development and Validation of a Mucosal Impedance Contour Analysis System to Distinguish Esophageal Disorders

Dhyanesh A. Patel et al.

GASTROENTEROLOGY (2019)

Review Gastroenterology & Hepatology

Confocal Laser Endomicroscopy in the Evaluation of Inflammatory Bowel Disease

Anna M. Buchner

INFLAMMATORY BOWEL DISEASES (2019)

Article Multidisciplinary Sciences

Assessing intestinal permeability in Crohn's disease patients using orally administered 52Cr-EDTA

Julius Z. H. von Martels et al.

PLOS ONE (2019)

Review Medicine, General & Internal

History of Inflammatory Bowel Diseases

Giovanni Clemente Actis et al.

JOURNAL OF CLINICAL MEDICINE (2019)

Article Gastroenterology & Hepatology

Past and Future Burden of Inflammatory Bowel Diseases Based on Modeling of Population-Based Data

Stephanie Coward et al.

GASTROENTEROLOGY (2019)

Review Gastroenterology & Hepatology

From bench to bedside: fecal calprotectin in inflammatory bowel diseases clinical setting

Maria Gloria Mumolo et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2018)

Article Gastroenterology & Hepatology

Association of endoscopic and histological remission with clinical course in patients of ulcerative colitis

Vikram Narang et al.

INTESTINAL RESEARCH (2018)

Article Gastroenterology & Hepatology

Understanding and Preventing the Global Increase of Inflammatory Bowel Disease

Gilaad G. Kaplan et al.

GASTROENTEROLOGY (2017)

Review Gastroenterology & Hepatology

Advanced endoscopy imaging in inflammatory bowel diseases

Ralf Kiesslich et al.

GASTROINTESTINAL ENDOSCOPY (2017)

Article Gastroenterology & Hepatology

Secretions of Bifidobacterium infantis and Lactobacillus acidophilus Protect Intestinal Epithelial Barrier Function

Shuangshuang Guo et al.

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION (2017)

Article Gastroenterology & Hepatology

Capillary Flow Rates in the Duodenum of Pediatric Ulcerative Colitis Patients Are Increased and Unrelated to Inflammation

Deenaz Zaidi et al.

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION (2017)

Article Gastroenterology & Hepatology

Increased Intestinal Permeability in Relatives of Patients With Crohn's Disease Is Not Associated With Small Bowel Ulcerations

Christopher W. Teshima et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2017)

Review Gastroenterology & Hepatology

Homeostasis of the gut barrier and potential biomarkers

Jerry M. Wells et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2017)

Review Gastroenterology & Hepatology

Leaky gut - concept or clinical entity?

Eamonn M. M. Quigley

CURRENT OPINION IN GASTROENTEROLOGY (2016)

Editorial Material Gastroenterology & Hepatology

Confocal Laser Endomicroscopy in the Management of IBD: Clearly Superior?

Alastair J. M. Watson

DIGESTIVE DISEASES AND SCIENCES (2016)

Editorial Material Gastroenterology & Hepatology

Confocal laser endomicroscopy for functional barrier imaging in Crohn's disease

Markus F. Neurath

ENDOSCOPY (2016)

Article Gastroenterology & Hepatology

Confocal laser endomicroscopy in ulcerative colitis: a longitudinal study of endomicroscopic changes and response to medical therapy

John Gasdal Karstensen et al.

GASTROINTESTINAL ENDOSCOPY (2016)

Article Gastroenterology & Hepatology

Increased Epithelial Gap Density in the Noninflamed Duodenum of Children With Inflammatory Bowel Diseases

Deenaz Zaidi et al.

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION (2016)

Article Gastroenterology & Hepatology

A Pilot Study of Confocal Laser Endomicroscopy to Predict Barrier Dysfunction and Relapse in Pediatric Inflammatory Bowel Disease

Anton Shavrov et al.

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION (2016)

Article Gastroenterology & Hepatology

Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE): Determining Therapeutic Goals for Treat-to-Target

L. Peyrin-Biroulet et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2015)

Review Gastroenterology & Hepatology

Confocal Laser Endomicroscopy in Inflammatory Bowel Disease - A Systematic Review

Ditlev Nytoft Rasmussen et al.

JOURNAL OF CROHNS & COLITIS (2015)

Article Gastroenterology & Hepatology

Confocal laser endomicroscopy: A new gold standard for the assessment of mucosal healing in ulcerative colitis

Vincent Mace et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2015)

Review Gastroenterology & Hepatology

The Economic and Quality-of-Life Burden of Crohn's Disease in Europe and the United States, 2000 to 2013: A Systematic Review

David N. Floyd et al.

DIGESTIVE DISEASES AND SCIENCES (2015)

Article Gastroenterology & Hepatology

Use of confocal laser endomicroscopy to predict relapse of ulcerative colitis

Chang-Qing Li et al.

BMC GASTROENTEROLOGY (2014)

Review Gastroenterology & Hepatology

Intestinal permeability - a new target for disease prevention and therapy

Stephan C. Bischoff et al.

BMC GASTROENTEROLOGY (2014)

Article Gastroenterology & Hepatology

Histologic Remission: The Ultimate Therapeutic Goal in Ulcerative Colitis?

Laurent Peyrin-Biroulet et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2014)

Article Gastroenterology & Hepatology

Confocal laser endomicroscopy

Shailendra S. Chauhan et al.

GASTROINTESTINAL ENDOSCOPY (2014)

Article Gastroenterology & Hepatology

Confocal laser endomicroscopy for prediction of disease relapse in ulcerative colitis: A pilot study

Andrea Buda et al.

JOURNAL OF CROHNS & COLITIS (2014)

Article Multidisciplinary Sciences

Global Spatio-Temporal Patterns in Human Migration: A Complex Network Perspective

Kyle F. Davis et al.

PLOS ONE (2013)

Article Gastroenterology & Hepatology

Assessment of Crohn's disease activity by confocal laser endomicroscopy

Helmut Neumann et al.

INFLAMMATORY BOWEL DISEASES (2012)

Article Gastroenterology & Hepatology

Increased Epithelial Gaps in the Small Intestine Are Predictive of Hospitalization and Surgery in Patients With Inflammatory Bowel Disease

Jean-Francois Turcotte et al.

CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY (2012)

Article Gastroenterology & Hepatology

Evaluation of oesophageal mucosa integrity by the intraluminal impedance technique

Ricard Farre et al.

Article Gastroenterology & Hepatology

Mind The Gaps Confocal Endomicroscopy Showed Increased Density of Small Bowel Epithelial Gaps in Inflammatory Bowel Disease

Julia J. Liu et al.

JOURNAL OF CLINICAL GASTROENTEROLOGY (2011)

Article Gastroenterology & Hepatology

Increased intestinal permeability in inflammatory bowel diseases assessed by iohexol test

Vanya A. Gerova et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2011)

Article Gastroenterology & Hepatology

The safety of intravenous fluorescein for confocal laser endomicroscopy in the gastrointestinal tract

M. B. Wallace et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2010)

Article Gastroenterology & Hepatology

Classification of Inflammation Activity in Ulcerative Colitis by Confocal Laser Endomicroscopy

Chang-Qing Li et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2010)

Article Gastroenterology & Hepatology

How Rapidly Should Remission Be Achieved?

Kim L. Isaacs

DIGESTIVE DISEASES (2010)

Editorial Material Gastroenterology & Hepatology

Confocal Laser Endomicroscopy: Technical Advances and Clinical Applications

Helmut Neumann et al.

GASTROENTEROLOGY (2010)

Review Gastroenterology & Hepatology

Mucosal Healing as an Index of Colitis Activity: Back to Histological Healing for Future Indices

Burton I. Korelitz

INFLAMMATORY BOWEL DISEASES (2010)

Article Gastroenterology & Hepatology

Confocal endomicroscopy in patients with ulcerative colitis

Osamu Watanabe et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2008)

Article Gastroenterology & Hepatology

Permanently increased mucosal permeability in patients with backwash ileitis after ileoanal pouch for ulcerative colitis

Anton J. Kroesen et al.

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY (2008)

Article Gastroenterology & Hepatology

Endoscopic biopsies in Ussing chambers evaluated for studies of macromolecular permeability in the human colon

C Wallon et al.

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY (2005)

Article Medical Laboratory Technology

A simple method for the analysis of urinary sucralose for use in tests of intestinal permeability

ADG Anderson et al.

ANNALS OF CLINICAL BIOCHEMISTRY (2005)