Journal
DIAGNOSTICS
Volume 13, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/diagnostics13111844
Keywords
gastric cancer; basement membrane-related gene; prognostic; immune; chemotherapy response
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This study identified six BM-related genes and developed a prognostic model for gastric cancer. It was found that activated CD4+ T cells and follicular T cells infiltrated more widely in the low-risk group, which also had higher TMB levels and better prognosis, favoring immunotherapy.
Background: The basement membrane (BM) serves as a major barrier to impede tumor cell invasion and extravasation during metastasis. However, the associations between BM-related genes and GC remain unclear. Methods: RNA expression data and corresponding clinical information of STAD samples were downloaded from the TCGA database. We identified BM-related subtypes and constructed a BM-related gene prognostic model using lasso-Cox regression analysis. We also investigated the single-cell properties of prognostic-related genes and the TME characteristic, TMB status, and chemotherapy response in high- and low-risk groups. Finally, we verified our results in the GEPIA database and human tissue specimens. Results: A six-gene lasso Cox regression model (APOD, CAPN6, GPC3, PDK4, SLC7A2, SVEP1) was developed. Activated CD4+ T cells and follicular T cells were shown to infiltrate more widely in the low-risk group. The low-risk group harbored significantly higher TMB and better prognosis, favoring immunotherapy. Conclusions: We constructed a six-gene BM-related prognostic model for predicting GC prognosis, immune cell infiltration, TMB status, and chemotherapy response. This research provides new ideas for developing more effective individualized treatment of GC patients.
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