4.6 Article

Curcumin Formulations for Better Bioavailability: What We Learned from Clinical Trials Thus Far?

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Summary: The findings of this study demonstrate that 8 weeks of curcumin supplementation and endurance training significantly improved glycemic indexes in middle-aged women with type 2 diabetes.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2021)

Review Chemistry, Medicinal

From Simple Mouth Cavities to Complex Oral Mucosal Disorders-Curcuminoids as a Promising Therapeutic Approach

Sosmitha Girisa et al.

Summary: Oral diseases are common worldwide and require safe and effective treatments. Curcumin, a natural polyphenol with diverse biological effects, shows promise in treating various oral conditions and has been studied in both in vitro and in vivo studies, as well as in clinical trials.

ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE (2021)

Article Dentistry, Oral Surgery & Medicine

Local application of curcumin-loaded nanoparticles as an adjunct to scaling and root planing in periodontitis: Randomized, placebo-controlled, double-blind split-mouth clinical trial

Cindy Grace Perez-Pacheco et al.

Summary: The study found that a single local application of nanoencapsulated curcumin did not have additional benefits to non-surgical periodontal treatment (NPT) in diseased sites.

CLINICAL ORAL INVESTIGATIONS (2021)

Article Dentistry, Oral Surgery & Medicine

Oral nano-curcuminon gingival inflammation in patients with gingivitis and mild periodontitis

Meisam Malekzadeh et al.

Summary: This study evaluated the effects of oral nano-curcumin on gingival inflammation in patients with gingivitis and mild periodontitis, finding that nano-curcumin has positive effects on reducing inflammation and gingival bleeding. Nano-curcumin capsules with systemic target site have higher bioavailability than topical forms.

CLINICAL AND EXPERIMENTAL DENTAL RESEARCH (2021)

Article Nutrition & Dietetics

Curcumin Improves Delayed Onset Muscle Soreness and Postexercise Lactate Accumulation

Alistair R. Mallard et al.

Summary: The study suggests that curcumin supplementation with improved bioavailability may reduce post-exercise muscle pain and lactate accumulation, leading to quicker recovery and potentially higher training intensity.

JOURNAL OF DIETARY SUPPLEMENTS (2021)

Article Integrative & Complementary Medicine

Effects of curcuminoids on inflammatory status in patients with nonalcoholic fatty liver disease: A randomized controlled trial

Maryam Saberi-Karimian et al.

COMPLEMENTARY THERAPIES IN MEDICINE (2020)

Article Cardiac & Cardiovascular Systems

Effects of fish oil and curcumin supplementation on cerebrovascular function in older adults: A randomized controlled trial

Julia C. Kuszewski et al.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2020)

Article Endocrinology & Metabolism

An Evaluation of a Nutraceutical with Berberine, Curcumin, Inositol, Banaba and Chromium Picolinate in Patients with Fasting Dysglycemia

Giuseppe Derosa et al.

DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY (2020)

Review Medicine, General & Internal

Properties, Extraction Methods, and Delivery Systems for Curcumin as a Natural Source of Beneficial Health Effects

Aleksandra Zielinska et al.

MEDICINA-LITHUANIA (2020)

Article Integrative & Complementary Medicine

Effects of nanocurcumin on inflammatory factors and clinical outcomes in critically ill patients with sepsis: A pilot randomized clinical trial

Arash Karimi et al.

EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE (2020)

Article Immunology

Nano-curcumin therapy, a promising method in modulating inflammatory cytokines in COVID-19 patients

Hamed Valizadeh et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

Review Pharmacology & Pharmacy

Recent developments in formulation design for improving oral bioavailability of curcumin: A review

Zhenqi Liu et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2020)

Article Rheumatology

Fish oil supplementation reduces osteoarthritis-specific pain in older adults with overweight/obesity

Julia C. Kuszewski et al.

RHEUMATOLOGY ADVANCES IN PRACTICE (2020)

Article Integrative & Complementary Medicine

The effects of nano-curcumin supplementation on Th1/Th17 balance in migraine patients: A randomized controlled clinical trial

Mona Djalali et al.

COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE (2020)

Article Integrative & Complementary Medicine

Comparison of oral Nano-Curcumin with oral prednisolone on oral lichen planus: a randomized double-blinded clinical trial

Seyed Javad Kia et al.

BMC COMPLEMENTARY MEDICINE AND THERAPIES (2020)

Article Biochemistry & Molecular Biology

The Effect of Nano-Curcumin Supplementation on Pentraxin 3 Gene Expression and Serum Level in Migraine Patients

Mona Djalali et al.

REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY (2020)

Article Integrative & Complementary Medicine

Effectiveness of an Alcohol-Free Chitosan-Curcuminoid Mouthwash Compared with Chlorhexidine Mouthwash in Denture Stomatitis Treatment: A Randomized Trial

Mian Waqar Mustafa et al.

JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE (2019)

Article Biochemistry & Molecular Biology

Nanocurcumin: A novel strategy in treating ankylosing spondylitis by modulating Th17 cells frequency and function

Mehrzad Hajialilo et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

Article Nutrition & Dietetics

Effective Timing of Curcumin Ingestion to Attenuate Eccentric Exercise-Induced Muscle Soreness in Men

Yoko Tanabe et al.

JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY (2019)

Article Biochemistry & Molecular Biology

Curcumin: Total-Scale Analysis of the Scientific Literature

Andy Wai Kan Yeung et al.

MOLECULES (2019)

Article Gastroenterology & Hepatology

Curcumin and inflammation in non-alcoholic fatty liver disease: a randomized, placebo controlled clinical trial

Saeede Saadati et al.

BMC GASTROENTEROLOGY (2019)

Review Biochemistry & Molecular Biology

Is curcumin bioavailability a problem in humans: lessons from clinical trials

Ajaikumar B. Kunnumakkara et al.

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2019)

Article Biochemistry & Molecular Biology

Curcuminoids plus piperine improve nonalcoholic fatty liver disease: A clinical trial

Yunes Panahi et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

Article Oncology

Treatment for benign thyroid nodules with a combination of natural extracts

Felician Stancioiu et al.

MOLECULAR MEDICINE REPORTS (2019)

Article Endocrinology & Metabolism

Effects of Highly Absorbable Curcumin in Patients with Impaired Glucose Tolerance and Non-Insulin-Dependent Diabetes Mellitus

Masafumi Funamoto et al.

JOURNAL OF DIABETES RESEARCH (2019)

Article Plant Sciences

Efficacy of phospholipidated curcumin in nonalcoholic fatty liver disease: a clinical study

Yunes Panahi et al.

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH (2019)

Article Sport Sciences

Effects of oral curcumin ingested before or after eccentric exercise on markers of muscle damage and inflammation

Yoko Tanabe et al.

SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS (2019)

Article Nutrition & Dietetics

The Effects of Curcumin on Serum Heat Shock Protein 27 Antibody Titers in Patients with Metabolic Syndrome

Farzaneh Mohammadi et al.

JOURNAL OF DIETARY SUPPLEMENTS (2019)

Article Dentistry, Oral Surgery & Medicine

Comparative evaluation of curcumin and antioxidants in the management of oral submucous fibrosis

Arpita Rai et al.

JOURNAL OF INVESTIGATIVE AND CLINICAL DENTISTRY (2019)

Article Dentistry, Oral Surgery & Medicine

Oral administration of nanomicelle curcumin in the prevention of radiotherapy-induced mucositis in head and neck cancers

Zahra Delavarian et al.

SPECIAL CARE IN DENTISTRY (2019)

Article Integrative & Complementary Medicine

Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: a comparative, randomized, double-blind, placebo-controlled study

Armine Haroyan et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2018)

Article Immunology

Changes in Th17 cells function after nanocurcumin use to treat multiple sclerosis

Sanam Dolati et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2018)

Article Endocrinology & Metabolism

Curcumin potentiates cholesterol-lowering effects of phytosterols in hypercholesterolaemic individuals. A randomised controlled trial

Jessica J. A. Ferguson et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2018)

Review Food Science & Technology

Recent advances in emulsion-based delivery approaches for curcumin: From encapsulation to bioaccessibility

Andrea Araiza-Calahorra et al.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2018)

Article Integrative & Complementary Medicine

Curcuma longa (Theracumin®): A Bioavailable Form of Curcumin and Its Cognitive Benefits

Stephanie Maxine Ross

HOLISTIC NURSING PRACTICE (2018)

Review Integrative & Complementary Medicine

Bioavailable curcumin formulations: A review of pharmacokinetic studies in healthy volunteers

Rohitash Jamwal

JOURNAL OF INTEGRATIVE MEDICINE-JIM (2018)

Review Food Science & Technology

Curcumin, an active component of turmeric (Curcuma longa), and its effects on health

Betul Kocaadam et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2017)

Review Pharmacology & Pharmacy

Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases

Ajaikumar B. Kunnumakkara et al.

BRITISH JOURNAL OF PHARMACOLOGY (2017)

Article Chemistry, Medicinal

Effects of Curcumin on Serum Vitamin E Concentrations in Individuals with Metabolic Syndrome

Akram Mohammadi et al.

PHYTOTHERAPY RESEARCH (2017)

Article Gastroenterology & Hepatology

Of mice and men: a novel dietary supplement for the treatment of ulcerative colitis

Shiran Shapira et al.

THERAPEUTIC ADVANCES IN GASTROENTEROLOGY (2017)

Review Medicine, Research & Experimental

Phytosomal curcumin: A review of pharmacokinetic, experimental and clinical studies

Hamed Mirzaei et al.

BIOMEDICINE & PHARMACOTHERAPY (2017)

Article Pharmacology & Pharmacy

Curcuminoids Plus Piperine Modulate Adipokines in Type 2 Diabetes Mellitus

Yunes Panahi et al.

CURRENT CLINICAL PHARMACOLOGY (2017)

Article Integrative & Complementary Medicine

Curcuminoids modify lipid profile in type 2 diabetes mellitus: A randomized controlled trial

Yunes Panahi et al.

COMPLEMENTARY THERAPIES IN MEDICINE (2017)

Review Medicine, Research & Experimental

Curcumin mediates anticancer effects by modulating multiple cell signaling pathways

Ajaikumar B. Kunnumakkara et al.

CLINICAL SCIENCE (2017)

Article Cardiac & Cardiovascular Systems

Curcumin Lowers Serum Lipids and Uric Acid in Subjects With Nonalcoholic Fatty Liver Disease: A Randomized Controlled Trial

Yunes Panahi et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2016)

Article Gastroenterology & Hepatology

Curcumin and Fennel Essential Oil Improve Symptoms and Quality of Life in Patients with Irritable Bowel Syndrome

Piero Portincasa et al.

JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES (2016)

Article Oncology

Intratumoral Concentrations and Effects of Orally Administered Micellar Curcuminoids in Glioblastoma Patients

Stephan Duetzmann et al.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2016)

Article Chemistry, Medicinal

Treatment of Non-alcoholic Fatty Liver Disease with Curcumin: A Randomized Placebo-controlled Trial

Sepideh Rahmani et al.

PHYTOTHERAPY RESEARCH (2016)

Article Respiratory System

Highly absorptive curcumin reduces serum atherosclerotic low-density lipoprotein levels in patients with mild COPD

Masafumi Funamoto et al.

INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (2016)

Review Pharmacology & Pharmacy

Therapeutic Applications of Curcumin Nanoformulations

Murali M. Yallapu et al.

AAPS JOURNAL (2015)

Article Physiology

Attenuation of indirect markers of eccentric exercise-induced muscle damage by curcumin

Yoko Tanabe et al.

EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY (2015)

Article Nutrition & Dietetics

Colloidal Submicron-Particle Curcumin Exhibits High Absorption Efficiency -A Double-Blind, 3-Way Crossover Study-

Yoichi Sunagawa et al.

JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY (2015)

Article Biotechnology & Applied Microbiology

Oral Curcumin (Meriva) Is Effective as an Adjuvant Treatment and Is Able to Reduce IL-22 Serum Levels in Patients with Psoriasis Vulgaris

Emiliano Antiga et al.

BIOMED RESEARCH INTERNATIONAL (2015)

Article Clinical Neurology

Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population

Katherine H. M. Cox et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2015)

Article Obstetrics & Gynecology

Endometriosis and pain: postsurgical alternative treatment in patients desiring pregnancy

Errico Zupi et al.

JOURNAL OF ENDOMETRIOSIS AND PELVIC PAIN DISORDERS (2015)

Review Pharmacology & Pharmacy

Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biology

Nicolas Bertrand et al.

ADVANCED DRUG DELIVERY REVIEWS (2014)

Article Biochemistry & Molecular Biology

Curcumin glucuronides: Assessing the proliferative activity against human cell lines

Ashutosh Pal et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2014)

Review Pharmacology & Pharmacy

Recent advances in curcumin nanoformulation for cancer therapy

Wing-Hin Lee et al.

EXPERT OPINION ON DRUG DELIVERY (2014)

Article Sport Sciences

Effects of Curcumin Supplementation on Exercise-Induced Oxidative Stress in Humans

M. Takahashi et al.

INTERNATIONAL JOURNAL OF SPORTS MEDICINE (2014)

Review Biochemistry & Molecular Biology

Hybrid Curcumin Compounds: A New Strategy for Cancer Treatment

Marie-Helene Teiten et al.

MOLECULES (2014)

Review Biochemistry & Molecular Biology

The Chemistry of Curcumin: From Extraction to Therapeutic Agent

Kavirayani Indira Priyadarsini

MOLECULES (2014)

Article Nutrition & Dietetics

Comparative absorption of curcumin formulations

Ralf Jaeger et al.

NUTRITION JOURNAL (2014)

Article Multidisciplinary Sciences

Investigation of the Effects of Curcumin on Serum Cytokines in Obese Individuals: A Randomized Controlled Trial

Shiva Ganjali et al.

SCIENTIFIC WORLD JOURNAL (2014)

Article Biotechnology & Applied Microbiology

Human Pharmacokinetics of High Dose Oral Curcumin and Its Effect on Heme Oxygenase-1 Expression in Healthy Male Subjects

Uros Klickovic et al.

BIOMED RESEARCH INTERNATIONAL (2014)

Review Pharmacology & Pharmacy

Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials

Subash C. Gupta et al.

AAPS JOURNAL (2013)

Article Pharmacology & Pharmacy

Drinkable Preparation of Theracurmin Exhibits High Absorption Efficiency—A Single-Dose, Double-Blind, 4-Way Crossover Study

Tatsuya Morimoto et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2013)

Review Food Science & Technology

Multitargeting by turmeric, the golden spice: From kitchen to clinic

Subash C. Gupta et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2013)

Review Multidisciplinary Sciences

Anti-Inflammatory Therapy in Chronic Disease: Challenges and Opportunities

Ira Tabas et al.

SCIENCE (2013)

Review Chemistry, Multidisciplinary

CurcuminuFrom Molecule to Biological Function

Tuba Esatbeyoglu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)

Article Oncology

Cancer Prevention with Promising Natural Products: Mechanisms of Action and Molecular Targets

Poyil Pratheeshkumar et al.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2012)

Review Pharmacology & Pharmacy

Curcumin nanoformulations: a future nanomedicine for cancer

Murali M. Yallapu et al.

DRUG DISCOVERY TODAY (2012)

Article Nanoscience & Nanotechnology

In vitro suppression of oral squamous cell carcinoma growth by ultrasound-mediated delivery of curcumin microemulsions

Hung-Yin Lin et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2012)

Article Nutrition & Dietetics

Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people

Robert A. DiSilvestro et al.

NUTRITION JOURNAL (2012)

Article Pharmacology & Pharmacy

Innovative Preparation of Curcumin for Improved Oral Bioavailability

Hiroki Sasaki et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2011)

Article Plant Sciences

Comparative Absorption of a Standardized Curcuminoid Mixture and Its Lecithin Formulation

John Cuomo et al.

JOURNAL OF NATURAL PRODUCTS (2011)

Article Toxicology

Curcumin protects DNA damage in a chronically arsenic-exposed population of West Bengal

Jaydip Biswas et al.

HUMAN & EXPERIMENTAL TOXICOLOGY (2010)

Article Pharmacology & Pharmacy

Synthesis and in vitro/in vivo anti-cancer evaluation of curcumin-loaded chitosan/poly(butyl cyanoacrylate) nanoparticles

Jinghua Duan et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2010)

Article Oncology

Phase II trial of curcumin in patients with advanced pancreatic cancer

Navneet Dhillon et al.

CLINICAL CANCER RESEARCH (2008)

Article Engineering, Biomedical

Micelles of poly(ethylene oxide)-b-poly(ε-caprolactone) as vehicles for the solubilization, stabilization, and controlled delivery of curcumin

Zengshuan Ma et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2008)

Review Medicine, Research & Experimental

Bioavailability of curcumin: Problems and promises

Preetha Anand et al.

MOLECULAR PHARMACEUTICS (2007)

Article Oncology

Comparison of systemic availability of curcumin with that of curcumin formulated with phosphatidylcholine

Timothy H. Marczylo et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2007)

Article Biochemical Research Methods

Oral bioavailabilit of curcurnin in rat and the herbal analysis from Curcuma longa by LC-MS/MS

Kuo-Yi Yang et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2007)

Article Gastroenterology & Hepatology

Combination treatment with curcumin and quercetin of adenomas in familial adenomatous polyposis

Marcia Cruz-Correa et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2006)

Article Pharmacology & Pharmacy

Studies of curcumin and curcuminoids.: XXVII.: Cyclodextrin complexation:: solubility, chemical and photochemical stability

HH Tonnesen et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2002)

Article Plant Sciences

Efficacy of turmeric on blood sugar and polyol pathway in diabetic albino rats

N Arun et al.

PLANT FOODS FOR HUMAN NUTRITION (2002)

Article Pharmacology & Pharmacy

Curcumin prevents adriamycin nephrotoxicity in rats

N Venkatesan et al.

BRITISH JOURNAL OF PHARMACOLOGY (2000)