Journal
ACS OMEGA
Volume 8, Issue 25, Pages 22836-22843Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsomega.3c01796
Keywords
-
Categories
Ask authors/readers for more resources
A novel family of julolidine-containing fluorescent rhodolsequipped with a wide variety of substituents was synthesized using a versatile two-step process. The synthesized compounds were fully characterized and demonstrated excellent fluorescence properties for microscopy imaging. The best candidate was conjugated to the therapeutic antibody trastuzumab through a copper-free strain-promoted azide-alkyne click reaction. The rhodol-labeled antibody was successfully used for in vitro confocal and two-photon microscopy imaging of Her2+ cells.
A novel family of julolidine-containing fluorescent rhodolsequippedwith a wide variety of substituents was synthesized in a versatiletwo-step process. The prepared compounds were fully characterizedand exhibited excellent fluorescence properties for microscopy imaging.The best candidate was conjugated to the therapeutic antibody trastuzumabthrough a copper-free strain-promoted azide-alkyne click reaction.The rhodol-labeled antibody was successfully applied for invitro confocal and two-photon microscopy imaging of Her2+cells.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available