Exploring the Phytochemical Profile and Biological Activities of Clerodendrum infortunatum

Article Chemistry, Applied

Chemical composition of a volatile fraction from the leaves ofClerodendrum infortunatumL.

Naresh Babu Gera et al.

Summary: The volatile composition and chemical analysis of Clerodendrum infortunatum L. leaves were investigated in this study. 1-octen-3-ol was identified as the main component along with other compounds.

NATURAL PRODUCT RESEARCH (2022)

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Article Oncology

Edible Sword Bean Extract Induces Apoptosis in Cancer Cells In Vitro and Inhibits Ascites and Solid Tumor Development In Vivo

Prathapan Abeesh et al.

Summary: Edible sword bean extract demonstrated antitumor potential by inhibiting cell growth and inducing apoptosis in both in vitro and in vivo studies on Dalton's lymphoma ascites and lung cancer cell lines.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2021)

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Article Oncology

Amomum subulatum Induces Apoptosis in Tumor Cells and Reduces Tumor Burden in Experimental Animals via Modulating Pro-Inflammatory Cytokines

Drishya Sudarsanan et al.

Summary: The methanolic extract of A. subulatum dry fruits showed anticancer potential by inducing apoptosis in DLA cells, reducing tumor burden, and increasing lifespan. It was found to be safer than the standard drug cyclophosphamide, making it a potential nutraceutical against cancer.

CANCER INVESTIGATION (2021)

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Review Medicine, Research & Experimental

Betulinic acid in the treatment of tumour diseases: Application and research progress

Wenkai Jiang et al.

Summary: Betulinic acid (BA) is a pentacyclic triterpene compound with antitumor activity, predominantly through inducing mitochondrial oxidative stress, regulating transcription factors, and inhibiting signaling pathways. It also enhances cancer cell sensitivity to chemotherapy drugs, demonstrating anticancer effects in various tumor diseases.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Biochemistry & Molecular Biology

Betulinic Acid Restricts Human Bladder Cancer Cell Proliferation In Vitro by Inducing Caspase-Dependent Cell Death and Cell Cycle Arrest, and Decreasing Metastatic Potential

So Young Kim et al.

Summary: The study demonstrates that betulinic acid induces apoptosis, necrosis, and cell cycle arrest in bladder cancer cells through modulation of cell cycle regulators and mitochondrial function, leading to decreased proliferation and migration.

MOLECULES (2021)

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Article Cell Biology

The anti-cancer effect of betulinic acid in u937 human leukemia cells is mediated through ROS-dependent cell cycle arrest and apoptosis

Cheol Park et al.

Summary: Betulinic acid (BA) exhibits anti-cancer properties in U937 leukemia cells by inducing cell cycle arrest at G2/M phase and apoptosis through mechanisms such as increasing ROS levels, down-regulating cyclins, increasing p21WAF1/CIP1 expression, reducing mitochondrial membrane potential, activating caspases, and triggering cytochrome c release.

ANIMAL CELLS AND SYSTEMS (2021)

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Article Biochemistry & Molecular Biology

Bioactive Abietane-Type Diterpenoid Glycosides from Leaves of Clerodendrum infortunatum (Lamiaceae)

Md Josim Uddin et al.

Summary: In this study, two previously undescribed diterpenoids and one known compound were isolated from Clerodendrum infortunatum leaves. These compounds, along with five phenylpropanoids previously isolated from the same source, were tested for their in vitro antidiabetic, anticancer, and anticholinesterase activities. One of the compounds showed potent inhibitory effects against mammalian alpha-amylase.

MOLECULES (2021)

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Article Medicine, Research & Experimental