The effect of aloin in blood glucose and antioxidants in male albino rats with Streptozoticin-induced diabetic

The anti-diabetic effect of aloin was examined in vivo in the current study, similar to the study, which for four weeks examined how aloin affected the blood sugar, insulin, and antioxidant levels in both healthy and diabetic rats generated by streptozotocin. Adult male albino rats were experimentally given a single intraperitoneal injection of 60 mg/kg of streptozotocin to induced diabetes. The in vitro experiment uti-lized blood samples, and adult male albino rats' kidneys, pancreas and liver were separated. In compar-ison to control diabetic rats, aloin isolates (30 mg / kg) body weight for 30 days considerably decreased serum glucose and effectively boosted serum insulin levels. Liver and kidney congeners of malondialde-hyde (MDA) were substantially decreased while, Catalase (CAT), superoxide dismutase (SOD) and Congeners Glutathione (GSH) were significantly boosted as contrasted to diabetic rats after aloin therapy. Moreover, a histological assessment of the pancreas was performed. These results show the promise of aloin at a dose of 30 mg/kg body weight for 30 days as an antidia-betic and antioxidant agent. (c) 2023 The Author(s). Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Automated summary

The anti-diabetic and antioxidant effects of aloin were examined in this study. Results showed that aloin significantly decreased blood glucose levels and increased insulin levels, while reducing malondialdehyde levels in the liver and kidneys and increasing the levels of catalase, superoxide dismutase, and glutathione. Histological assessment of the pancreas was also performed. Therefore, aloin has potential as an anti-diabetic and antioxidant agent at a dose of 30 mg/kg body weight for 30 days.