Journal
LIFE SCIENCES
Volume 167, Issue -, Pages 39-45Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.lfs.2016.10.018
Keywords
Phosphatidylinositol-4,5-bisphosphate; 3-kinase; PI3K; Protein kinase B; AKT; Endocytosis; Exocytosis; Membrane trafficking; Caveolae; Clathrin
Funding
- National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health [AR063084]
- American Heart Association
- Ohio State University/Nationwide Children's Hospital Center for Muscle Health and Neuromuscular Disorders
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Phosphatidylinositol-4,5-bisphosphate 3-kinases (PI3Ks) are regulatory enzymes involved in the generation of lipid species that modulate cellular signaling pathways through downstream effectors to influence a variety of cellular functions. Years of intensive study of PI3Ks have produced a significant body of literature in many areas, including that PI3K can mediate intracellular vesicular trafficking and through these actions contribute to a number of important physiological functions. This review focuses on the crucial roles that PI3K and AKT, a major downstreampartner of PI3K, play in the regulation of vesicle trafficking during various forms of vesicular endocytosis and exocytosis. (C) 2016 Elsevier Inc. All rights reserved.
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