4.6 Review

Pulmonary bacteriophage and cystic fibrosis airway mucus: friends or foes?

Related references

Note: Only part of the references are listed.
Article Immunology

Phage Therapy of Mycobacterium Infections: Compassionate Use of Phages in 20 Patients With Drug-Resistant Mycobacterial Disease

Rebekah M. Dedrick et al.

Summary: Bacteriophage therapy shows potential as an adjunctive treatment for nontuberculous Mycobacterium infections. This study observed no adverse reactions, favorable outcomes in at least 50% of patients, and no evidence of phage resistance.

CLINICAL INFECTIOUS DISEASES (2023)

Article Virology

The role of the animal host in the management of bacteriophage resistance during phage therapy

Baptiste Gaborieau et al.

Summary: Multi-drug-resistant bacteria are associated with higher morbidity and mortality. Phage therapy, the use of bacteriophages to cure infections, is being investigated as an alternative to antibiotics. However, the limitations lie in the coevolution between bacteria and bacteriophages, which affects the success of phage therapy. This review discusses the influence of animal hosts on phage resistance and the value of in vitro assays for predicting in vivo dynamics.

CURRENT OPINION IN VIROLOGY (2023)

Editorial Material Infectious Diseases

Phage therapy in pediatrics: the way forward for difficult-to-treat infections?

Annaleise R. Howard-Jones et al.

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY (2022)

Article Multidisciplinary Sciences

Combination of pre-adapted bacteriophage therapy and antibiotics for treatment of fracture-related infection due to pandrug-resistant Klebsiella pneumoniae

Anais Eskenazi et al.

Summary: This case study describes the successful treatment of a bombing victim with a fracture-related pandrug-resistant Klebsiella pneumoniae infection. The combination therapy of pre-adapted bacteriophage and antibiotics resulted in significant clinical, microbiological, and radiological improvement.

NATURE COMMUNICATIONS (2022)

Article Respiratory System

Mucus and mucus flake composition and abundance reflect inflammatory and infection status in cystic fibrosis

Matthew R. Markovetz et al.

Summary: The study reveals that the concentration of mucin and DNA in bronchoalveolar lavage fluid (BALF) progressively increases in cystic fibrosis (CF) patients, along with the presence of non-swellable mucus flakes. The composition and properties of these mucus flakes serve as useful markers for evaluating inflammatory and infection-based changes in CF airways.

JOURNAL OF CYSTIC FIBROSIS (2022)

Article Cell Biology

Combination of in vivo phage therapy data with in silico model highlights key parameters for pneumonia treatment efficacy

Raphaelle Delattre et al.

Summary: This article introduces a strategy that combines in vitro and in vivo experiments with a mathematical model to study the interactions between bacteriophage and bacteria in the context of antibiotic-resistant infections. The article also proposes a method to estimate key parameters for bacteriophage therapeutic efficacy.

CELL REPORTS (2022)

Article Infectious Diseases

Ceftaroline versus vancomycin for treatment of acute pulmonary exacerbations of cystic fibrosis in adults

Marc D. Esquivel et al.

Summary: This retrospective observational cohort study compared the safety and efficacy of ceftaroline with vancomycin for the treatment of methicillin-resistant Staphylococcus aureus (MRSA)-mediated acute pulmonary exacerbations (APEs) in adult cystic fibrosis (CF) patients. The study found that ceftaroline was a viable alternative treatment option for MRSA-mediated APEs in adult CF patients, with similar outcomes to vancomycin.

JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE (2022)

Article Multidisciplinary Sciences

Mucin induces CRISPR-Cas defense in an opportunistic pathogen

Gabriel Magno de Freitas Almeida et al.

Summary: This study reveals that mucin derived from mucus can greatly enhance bacterial defenses against phages, particularly under low nutrient conditions. Furthermore, the presence of competitor bacteria further strengthens the defense mechanisms. These findings highlight the importance of ecological factors in determining bacterial defense strategies against phages.

NATURE COMMUNICATIONS (2022)

Review Infectious Diseases

Efficacy of phage therapy in preclinical models of bacterial infection: a systematic review and meta-analysis

Sergio Alejandro Gomez-Ochoa et al.

Summary: This study found that phage therapy significantly improved animal survival and reduced organ bacterial loads compared with placebo in preclinical animal models. However, high heterogeneity was observed in some comparisons, indicating the need for more evidence to identify factors influencing phage therapy performance for future clinical application.

LANCET MICROBE (2022)

Article Respiratory System

Variation in treatment preferences of pulmonary exacerbations among Australian and New Zealand cystic fibrosis physicians

Grace Currie et al.

Summary: There is considerable variation among CF physicians in Australia and New Zealand in their preferred choice of primary antibiotic and use of dornase alfa for CF pulmonary exacerbations. These preferences are driven by professional opinion, highlighting the need for more high-quality clinical trial evidence to inform physician decision making.

BMJ OPEN RESPIRATORY RESEARCH (2021)

Article Pharmacology & Pharmacy

Synergistic activity of phage PEV20-ciprofloxacin combination powder formulation-A proof-of-principle study in a P. aeruginosa lung infection model

Yu Lin et al.

Summary: The study demonstrated that the combination powder of PEV20 and ciprofloxacin significantly reduced the bacterial load in mouse lungs infected with clinical P. aeruginosa strain. The powder also showed reduced lung inflammation associated with its bactericidal effect.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2021)

Review Biochemistry & Molecular Biology

The pharmacokinetics of antibiotics in cystic fibrosis

Anne M. Akkerman-Nijland et al.

Summary: Dosage of antibiotics in cystic fibrosis patients is challenging due to altered pharmacokinetics and difficulty in lung tissue penetration. Different antibiotic classes have varying effects on drug metabolism and excretion, with specific guidelines recommended for optimizing therapy. Inhalation therapy can help achieve higher local antibiotic concentrations in the airways, minimizing systemic exposure and toxicity risk.

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2021)

Review Pediatrics

Bacteriophage therapy for infections in CF

Benjamin K. Chan et al.

Summary: Phage therapy is gaining renewed interest as a potential strategy to combat antibiotic-resistant bacterial infections, particularly in cystic fibrosis patients, but further research is needed to assess its clinical benefits and efficacy.

PEDIATRIC PULMONOLOGY (2021)

Review Microbiology

Overcoming Challenges to Make Bacteriophage Therapy Standard Clinical Treatment Practice for Cystic Fibrosis

Renee N. Ng et al.

Summary: This review discusses the use of primary airway epithelial cells to represent the mucoenvironment of the CF lungs for validating the safety and efficacy of phage therapy. The combination of phage therapy and antimicrobials is gaining attention for delaying the onset of MDR infections. Efforts to translate phage therapy into standard clinical practice have gained traction in the past 5 years, calling for collaboration and standardized policies.

FRONTIERS IN MICROBIOLOGY (2021)

Article Microbiology

Targeting of Mammalian Glycans Enhances Phage Predation in the Gastrointestinal Tract

Sabrina Green et al.

Summary: The interaction of bacteriophages and their prokaryotic hosts in the gastrointestinal tract is crucial for the health of the host, and a novel phage with enhanced lytic cycle in intestinal environments has been discovered. This finding offers the potential for developing mucosal targeting phage to selectively remove invasive pathobiont species.
Article Microbiology

A Novel Group of Promiscuous Podophages Infecting Diverse Gammaproteobacteria from River Communities Exhibits Dynamic Intergenus Host Adaptation

Daniel Cazares et al.

Summary: This study isolated and characterized a group of six novel phages named Atoyac, with a broad host range infecting bacteria from six different genera. The research revealed that similar phages exhibit different infection efficiency and adaptation patterns in diverse hosts, highlighting the dynamic nature of phage promiscuity.

MSYSTEMS (2021)

Review Infectious Diseases

Cystic Fibrosis: Recent Insights into Inhaled Antibiotic Treatment and Future Perspectives

Giovanni Taccetti et al.

Summary: Inhaled antibiotics have greatly improved respiratory diseases in cystic fibrosis patients, especially in treating chronic Pseudomonas aeruginosa infections. These antibiotics offer advantages over systemic therapy by delivering high drug concentrations directly to the lungs. Alternating treatment with inhaled antibiotics is crucial for improving patient outcomes, and long-term use can prevent acute pulmonary exacerbations.

ANTIBIOTICS-BASEL (2021)

Article Virology

Bacteriophage cocktail and phage antibiotic synergism as promising alternatives to conventional antibiotics for the control of multi-drug-resistant uropathogenic Escherichia coli

Shikha Malik et al.

Summary: The study demonstrated that utilizing multiple phages and phage-antibiotic combinations could enhance the control of multidrug-resistant bacteria, offering a potential solution to the challenges posed by the rapidly increasing drug-resistant strains.

VIRUS RESEARCH (2021)

Review Virology

The Safety and Toxicity of Phage Therapy: A Review of Animal and Clinical Studies

Dan Liu et al.

Summary: Phage therapy has garnered renewed interest due to increasing rates of antibiotic resistant bacteria infections. Safety and toxicity data associated with phage therapy in animals and humans have been systematically reviewed from English language publications between 2008-2021. While some adverse events were found in relation to phage therapy, serious events were extremely rare, highlighting the need for structured safety and tolerability endpoints in the therapeutic use of phages. Comprehensive and standardized reporting of potential toxicities associated with phage therapy has generally been lacking in published literature.

VIRUSES-BASEL (2021)

Review Microbiology

Current and Emerging Therapies to Combat Cystic Fibrosis Lung Infections

Jim Manos

Summary: The aim of antimicrobial treatment for bacterial infections in CF lung is to improve infection outcomes for patients. Current treatments include antibiotics with physical therapy, but there are challenges such as bacterial survival in biofilm aggregates. Emerging treatments involving novel compounds or bacteriophages show promise in disrupting biofilm matrix and improving antibiotic access.

MICROORGANISMS (2021)

Review Multidisciplinary Sciences

The arms race between bacteria and their phage foes

Hannah G. Hampton et al.

NATURE (2020)

Article Microbiology

Safety of bacteriophage therapy in severe Staphylococcus aureus infection

Aleksandra Petrovic Fabijan et al.

NATURE MICROBIOLOGY (2020)

Article Multidisciplinary Sciences

Pleiotropy complicates a trade-off between phage resistance and antibiotic resistance

Alita R. Burmeister et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Virology

Abortive Infection: Bacterial Suicide as an Antiviral Immune Strategy

Anna Lopatina et al.

ANNUAL REVIEW OF VIROLOGY, VOL 7, 2020 (2020)

Review Microbiology

Achromobacter Infections and Treatment Options

Burcu Isler et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2020)

Article Primary Health Care

Educating Patients on Unnecessary Antibiotics: Personalizing Potential Harm Aids Patient Understanding

Benjamin J. Miller et al.

JOURNAL OF THE AMERICAN BOARD OF FAMILY MEDICINE (2020)

Article Materials Science, Biomaterials

Mucus and Mucin Environments Reduce the Efficacy of Polymyxin and Fluoroquinolone Antibiotics against Pseudomonas aeruginosa

Tahoura Samad et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2019)

Article Biochemistry & Molecular Biology

Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus

Rebekah M. Dedrick et al.

NATURE MEDICINE (2019)

Article Cell Biology

Mucus accumulation in the lungs precedes structural changes and infection in children with cystic fibrosis

Charles R. Esther et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

Article Surgery

Early clinical experience of bacteriophage therapy in 3 lung transplant recipients

Saima Aslam et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2019)

Article Microbiology

Mucin glycans attenuate the virulence of Pseudomonas aeruginosa in infection

Kelsey M. Wheeler et al.

NATURE MICROBIOLOGY (2019)

Review Pharmacology & Pharmacy

Animal Models in the Pathophysiology of Cystic Fibrosis

Anna Semaniakou et al.

FRONTIERS IN PHARMACOLOGY (2019)

Article Critical Care Medicine

Changing Prevalence of Lower Airway Infections in Young Children with Cystic Fibrosis

Oded Breuer et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2019)

Article Microbiology

Pseudomonas aeruginosa defends against phages through type IV pilus glycosylation

Hanjeong Harvey et al.

NATURE MICROBIOLOGY (2018)

Review Pharmacology & Pharmacy

The biology of mucus: Composition, synthesis and organization

Rama Bansil et al.

ADVANCED DRUG DELIVERY REVIEWS (2018)

Review Respiratory System

ECFS best practice guidelines: the 2018 revision

Carlo Castellani et al.

JOURNAL OF CYSTIC FIBROSIS (2018)

Article Pharmacology & Pharmacy

Use of a Primary Epithelial Cell Screening Tool to Investigate Phage Therapy in Cystic Fibrosis

Stephanie Trend et al.

FRONTIERS IN PHARMACOLOGY (2018)

Article Biochemistry & Molecular Biology

Synthetic Immunotherapeutics against Gram-negative Pathogens

Mary Sabulski Feigman et al.

CELL CHEMICAL BIOLOGY (2018)

Article Evolutionary Biology

Phage treatment of an aortic graft infected with & IT;Pseudomonas aeruginosa & IT;

Benjamin K. Chan et al.

EVOLUTION MEDICINE AND PUBLIC HEALTH (2018)

Review Pharmacology & Pharmacy

Physicochemical properties of mucus and their impact on transmucosal drug delivery

Jasmim Leal et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

Article Chemistry, Medicinal

Population Pharmacokinetics of Tobramycin Inhalation Solution in Pediatric Patients With Cystic Fibrosis

Xinting Wang et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2017)

Article Multidisciplinary Sciences

Communication between viruses guides lysis-lysogeny decisions

Zohar Erez et al.

NATURE (2017)

Editorial Material Respiratory System

Phage therapy is highly effective against chronic lung infections with Pseudomonas aeruginosa

Elaine M. Waters et al.

THORAX (2017)

Review Immunology

Understanding the Entanglement: Neutrophil Extracellular Traps (NETs) in Cystic Fibrosis

Saira R. Martinez-Aleman et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2017)

Article Biology

Clinical impact of Achromobacter xylosoxidans colonization/infection in patients with cystic fibrosis

M. C. Firmida et al.

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH (2016)

Article Biochemistry & Molecular Biology

Multi-level regulation of cellular glycosylation: from genes to transcript to enzyme to structure

Sriram Neelamegham et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2016)

Article Respiratory System

Continuous alternating inhaled antibiotic therapy in CF: A single center retrospective analysis

C. Van de Kerkhove et al.

JOURNAL OF CYSTIC FIBROSIS (2016)

Article Biotechnology & Applied Microbiology

Coral Mucus Is a Hot Spot for Viral Infections

Hanh Nguyen-Kim et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2015)

Article Biochemistry & Molecular Biology

Exploring the interactions between bacteriophage-encoded glycan binding proteins and carbohydrates

David J. Simpson et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2015)

Article Multidisciplinary Sciences

Subdiffusive motion of bacteriophage in mucosal surfaces increases the frequency of bacterial encounters

Jeremy J. Barr et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Biotechnology & Applied Microbiology

Burkholderia cepacia Complex Phage-Antibiotic Synergy (PAS): Antibiotics Stimulate Lytic Phage Activity

Fatima Kamal et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2015)

Review Respiratory System

The problems of antibiotic resistance in cystic fibrosis and solutions

Carla Lopez-Causape et al.

EXPERT REVIEW OF RESPIRATORY MEDICINE (2015)

Article Biochemistry & Molecular Biology

Lung Phenotype of Juvenile and Adult Cystic Fibrosis Transmembrane Conductance Regulator-Knockout Ferrets

Xingshen Sun et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2014)

Article Medicine, General & Internal

Antimicrobial resistance in the respiratory microbiota of people with cystic fibrosis

Laura J. Sherrard et al.

LANCET (2014)

Article Microbiology

Temperature dependent bacteriophages of a tropical bacterial pathogen

Jinyu Shan et al.

FRONTIERS IN MICROBIOLOGY (2014)

Review Respiratory System

Current concepts: host-pathogen interactions in cystic fibrosis airways disease

Anthony C. Tang et al.

EUROPEAN RESPIRATORY REVIEW (2014)

Article Infectious Diseases

Bacteriophages and Biofilms

David R. Harper et al.

ANTIBIOTICS-BASEL (2014)

Article Immunology

Gene-Silencing Antisense Oligomers Inhibit Acinetobacter Growth In Vitro and In Vivo

Bruce L. Geller et al.

JOURNAL OF INFECTIOUS DISEASES (2013)

Article Medicine, General & Internal

Risk Factors for Bronchiectasis in Children with Cystic Fibrosis

Peter D. Sly et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Multidisciplinary Sciences

A quorum-sensing inhibitor blocks Pseudomonas aeruginosa virulence and biofilm formation

Colleen T. O'Loughlin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Multidisciplinary Sciences

Bacteriophage adhering to mucus provide a non-host-derived immunity

Jeremy J. Barr et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Respiratory System

Treatment of pulmonary exacerbations in cystic fibrosis

Jayesh M. Bhatt

EUROPEAN RESPIRATORY REVIEW (2013)

Article Physiology

The air-liquid interface and use of primary cell cultures are important to recapitulate the transcriptional profile of in vivo airway epithelia

Alejandro A. Pezzulo et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2011)

Article Critical Care Medicine

Infection, Inflammation, and Lung Function Decline in Infants with Cystic Fibrosis

Naveen Pillarisetti et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2011)

Article Microbiology

Quorum Sensing Inhibitors Increase the Susceptibility of Bacterial Biofilms to Antibiotics In Vitro and In Vivo

Gilles Brackman et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2011)

Article Respiratory System

Does bacterial density in cystic fibrosis sputum increase prior to pulmonary exacerbation?

Franziska A. Stressmann et al.

JOURNAL OF CYSTIC FIBROSIS (2011)

Article Medicine, General & Internal

Economic burden ofPseudomonas aeruginosainfection in patients with cystic fibrosis

Sujit S. Sansgiry et al.

JOURNAL OF MEDICAL ECONOMICS (2011)

Article Biotechnology & Applied Microbiology

Evaluation of lytic activity of staphylococcal bacteriophage Sb-1 against freshly isolated clinical pathogens

Leila Kvachadze et al.

MICROBIAL BIOTECHNOLOGY (2011)

Article Biochemistry & Molecular Biology

The Cystic Fibrosis Transmembrane Conductance Regulator Impedes Proteolytic Stimulation of the Epithelial Na+ Channel

Martina Gentzsch et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Immunology

Bacteriophage Therapy of Salmonella enterica: A Fresh Appraisal of Bacteriophage Therapy

Rosanna Capparelli et al.

JOURNAL OF INFECTIOUS DISEASES (2010)

Article Immunology

Bacteriophages Can Treat and Prevent Pseudomonas aeruginosa Lung Infections

Laurent Debarbieux et al.

JOURNAL OF INFECTIOUS DISEASES (2010)

Review Pharmacology & Pharmacy

Resurgence of Colistin: A Review of Resistance, Toxicity, Pharmacodynamics, and Dosing

Lauren M. Lim et al.

PHARMACOTHERAPY (2010)

Article Cell Biology

Cystic Fibrosis Pigs Develop Lung Disease and Exhibit Defective Bacterial Eradication at Birth

David A. Stoltz et al.

SCIENCE TRANSLATIONAL MEDICINE (2010)

Review Pharmacology & Pharmacy

Human primary bronchial lung cell constructs: The new respiratory models

Kelly BeruBe et al.

TOXICOLOGY (2010)

Article Biochemistry & Molecular Biology

Tobramycin and FDA-Approved Iron Chelators Eliminate Pseudomonas aeruginosa Biofilms on Cystic Fibrosis Cells

Sophie Moreau-Marquis et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2009)

Article Chemistry, Multidisciplinary

Cationic Amphiphiles Increase Activity of Aminoglycoside Antibiotic Tobramycin in the Presence of Airway Polyelectrolytes

Kirstin R. Purdy Drew et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)

Review Respiratory System

Neutrophils in cystic fibrosis

D. G. Downey et al.

THORAX (2009)

Review Pediatrics

What's new in cystic fibrosis? From treating symptoms to correction of the basic defect

Marijke Proesmans et al.

EUROPEAN JOURNAL OF PEDIATRICS (2008)

Article Immunology

Human host defense peptide LL-37 prevents bacterial biofilm formation

Joerg Overhage et al.

INFECTION AND IMMUNITY (2008)

Article Infectious Diseases

Phage therapy experience at the Eliava Institute

M. Kutateladze et al.

MEDECINE ET MALADIES INFECTIEUSES (2008)

Article Multidisciplinary Sciences

A physical linkage between cystic fibrosis airway surface dehydration and Pseudomonas aeruginosa biofilms

Hirotoshi Matsui et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Review Biochemistry & Molecular Biology

Glycosylation in cellular mechanisms of health and disease

Kazuaki Ohtsubo et al.

Article Critical Care Medicine

Adult cystic fibrosis exacerbations and new strains of Pseudomonas aeruginosa

SD Aaron et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2004)

Review Microbiology

The interaction of phage and biofilms

IW Sutherland et al.

FEMS MICROBIOLOGY LETTERS (2004)

Article Critical Care Medicine

Macromolecular interactions and ion transport in cystic fibrosis

WB Guggino et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2004)

Article Biotechnology & Applied Microbiology

Evaluation of a cocktail of three bacteriophages for biocontrol of Escherichia coli O157:H7

G O'Flynn et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2004)

Article Biochemistry & Molecular Biology

Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice

M Mall et al.

NATURE MEDICINE (2004)

Article Pediatrics

Methicillin resistant Staphylococcus aureus (MRSA) infection in cystic fibrosis

LS Miall et al.

ARCHIVES OF DISEASE IN CHILDHOOD (2001)