Case report: Unusual viral evolutions following antiviral therapies in a patient with concurrent hepatitis B virus and hepatitis C virus infection

Review Biochemistry & Molecular Biology

Hepatitis B Flare in Hepatitis B e Antigen-Negative Patients: A Complicated Cascade of Innate and Adaptive Immune Responses

Ming-Ling Chang et al.

Summary: Chronic hepatitis B virus (HBV) infection is a complex process involving interactions among HBV, hepatocytes, and the host immune system. Hepatitis B flares can occur in both HBeAg-positive and HBeAg-negative patients, and the clinical manifestations vary. This review focuses on the management of HBV flares in HBeAg-negative chronic hepatitis B (CHB) patients and provides insight into the immunopathogenesis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Immunology

Dynamic Changes of Cytokine Profiles and Virological Markers Associated With HBsAg Loss During Peginterferon Alpha-2a Treatment in HBeAg-Positive Chronic Hepatitis B Patients

Minghui Li et al.

Summary: This study investigated the dynamic changes of cytokines and virological markers during HBsAg loss, and found that these changes were associated with the efficacy of PEG-IFN alpha-2a treatment in HBeAg-positive chronic hepatitis B (CHB) patients.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Gastroenterology & Hepatology