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Metabolomic Footprint of Disrupted Energetics and Amino Acid Metabolism in Neurodegenerative Diseases: Perspectives for Early Diagnosis and Monitoring of Therapy

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Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

Yu Yamazaki et al.

NATURE REVIEWS NEUROLOGY (2019)

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Dysbiosis of gut microbiota in a selected population of Parkinson's patients

Daniele Pietrucci et al.

PARKINSONISM & RELATED DISORDERS (2019)

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Applications of amyloid, tau, and neuroinflammation PET imaging to Alzheimer's disease and mild cognitive impairment

Avinash Chandra et al.

HUMAN BRAIN MAPPING (2019)

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α-Synuclein pathology in Parkinson's disease and related α-synucleinopathies

Michael X. Henderson et al.

NEUROSCIENCE LETTERS (2019)

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Systemic and central nervous system metabolic alterations in Alzheimer's disease

Vera van der Velpen et al.

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Branched Chain Amino Acids

Michael Neinast et al.

ANNUAL REVIEW OF PHYSIOLOGY, VOL 81 (2019)

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Tryptophan Metabolism in Inflammaging: From Biomarker to Therapeutic Target

Freek J. H. Sorgdrager et al.

FRONTIERS IN IMMUNOLOGY (2019)

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The role of membrane trafficking in the processing of amyloid precursor protein and production of amyloid peptides in Alzheimer's disease

Jing Zhi A. Tan et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2019)

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Indoleamine 2,3-dioxygenase as a novel therapeutic target for Huntington's disease

Fanni A. Boros et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2019)

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Recent advances and perspectives of metabolomics-based investigations in Parkinson's disease

Yaping Shao et al.

MOLECULAR NEURODEGENERATION (2019)

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Kynurenine 3-Monooxygenase Activity in Human Primary Neurons and Effect on Cellular Bioenergetics Identifies New Neurotoxic Mechanisms

Gloria Castellano-Gonzalez et al.

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Future Therapeutic Perspectives into the Alzheimer's Disease Targeting the Oxidative Stress Hypothesis

Jessika P. Teixeira et al.

MOLECULES (2019)

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Deutetrabenazine in the treatment of Huntington's disease

Alby Richard et al.

NEURODEGENERATIVE DISEASE MANAGEMENT (2019)

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Brain Fuel Utilization in the Developing Brain

Pascal Steiner

ANNALS OF NUTRITION AND METABOLISM (2019)

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Mitochondrial Dysfunction in Parkinson's Disease-Cause or Consequence?

Chun Chen et al.

BIOLOGY-BASEL (2019)

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Huntington's disease: a clinical review

P. McColgan et al.

EUROPEAN JOURNAL OF NEUROLOGY (2018)

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Association of branched-chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer's disease: A prospective study in eight cohorts

Juho Tynkkynen et al.

ALZHEIMERS & DEMENTIA (2018)

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Evidence for brain glucose dysregulation in Alzheimer's disease

Yang An et al.

ALZHEIMERS & DEMENTIA (2018)

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Nicotinamide Adenine Dinucleotide Metabolism and Neurodegeneration

Mariana Pehar et al.

ANTIOXIDANTS & REDOX SIGNALING (2018)

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The concept of alpha-synuclein as a prion-like protein: ten years after

Jennifer A. Steiner et al.

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Glycophagy: An emerging target in pathology

Hong Zhao et al.

CLINICA CHIMICA ACTA (2018)

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Cerebrospinal Fluid Biomarkers for Early and Differential Alzheimer's Disease Diagnosis

Maria Bjerke et al.

JOURNAL OF ALZHEIMERS DISEASE (2018)

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Mitochondria and Mitochondrial Cascades in Alzheimer's Disease

Russell H. Swerdlow

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Alternations of Metabolic Profile and Kynurenine Metabolism in the Plasma of Parkinson's Disease

Kuo-Hsuan Chang et al.

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Alpha-synuclein: Pathology, mitochondrial dysfunction and neuroinflammation in Parkinson's disease

Emily M. Rocha et al.

NEUROBIOLOGY OF DISEASE (2018)

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Mitochondrial calcium imbalance in Parkinson's disease

Marthe H. R. Ludtmann et al.

NEUROSCIENCE LETTERS (2018)

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The NAD plus Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC and Fly Models of Parkinson's Disease

David C. Schoendorf et al.

CELL REPORTS (2018)

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Promising Metabolite Profiles in the Plasma and CSF of Early Clinical Parkinson's Disease

Daniel Stoessel et al.

FRONTIERS IN AGING NEUROSCIENCE (2018)

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On Cell Loss and Selective Vulnerability of Neuronal Populations in Parkinson's Disease

Nicolas Giguere et al.

FRONTIERS IN NEUROLOGY (2018)

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Intercellular Spread of Protein Aggregates in Neurodegenerative Disease

Albert A. Davis et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 34 (2018)

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Norepinephrine stimulates glycogenolysis in astrocytes to fuel neurons with lactate

Jay S. Coggan et al.

PLoS Computational Biology (2018)

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Metabolomic investigations in cerebrospinal fluid of Parkinson's disease

Desiree Willkommen et al.

PLOS ONE (2018)

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Elevated Glutamate and Glutamine Levels in the Cerebrospinal Fluid of Patients With Probable Alzheimer's Disease and Depression

Caroline Madeira et al.

FRONTIERS IN PSYCHIATRY (2018)

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A Critical Evaluation of Wet Biomarkers for Huntington's Disease: Current Status and Ways Forward

Edina Silajdzic et al.

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Plasma concentrations of 8-hydroxy-2'-deoxyguanosine and risk of kidney disease and death in individuals with type 1 diabetes

Manuel Sanchez et al.

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β-Hydroxybutyrate in the Brain: One Molecule, Multiple Mechanisms

Lavanya B. Achanta et al.

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Fats for thoughts: An update on brain fatty acid metabolism

Adele Romano et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2017)

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Epidemiology of Parkinson's disease

Ole-Bjorn Tysnes et al.

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Changes in kynurenine pathway metabolism in Parkinson patients with L-DOPA-induced dyskinesia

Jesper F. Havelund et al.

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Branched-Chain Amino Acids and Brain Metabolism

Justin E. Sperringer et al.

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Recent evidence for an expanded role of the kynurenine pathway of tryptophan metabolism in neurological diseases

Michael D. Lovelace et al.

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Endocytic vesicle rupture is a conserved mechanism of cellular invasion by amyloid proteins

William P. Flavin et al.

ACTA NEUROPATHOLOGICA (2017)

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Metabolic network failures in Alzheimer's disease: A biochemical road map

Jon B. Toledo et al.

ALZHEIMERS & DEMENTIA (2017)

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Striatal synaptic dysfunction and altered calcium regulation in Huntington disease

Lynn A. Raymond

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Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics

Patrycja Puchalska et al.

CELL METABOLISM (2017)

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Brain fluorodeoxyglucose (FDG) PET in dementia

Takashi Kato et al.

AGEING RESEARCH REVIEWS (2016)

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8-Hydroxy-2-Deoxyguanosine Levels and Cardiovascular Disease: A Systematic Review and Meta-Analysis of the Literature

Alessandro Di Minno et al.

ANTIOXIDANTS & REDOX SIGNALING (2016)

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Metabolite mapping reveals severe widespread perturbation of multiple metabolic processes in Huntington's disease human brain

Stefano Patassini et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2016)

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An impaired metabolism of nucleotides underpins a novel mechanism of cardiac remodeling leading to Huntington's disease related cardiomyopathy

Marta Toczek et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2016)

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NAD+ metabolism: Bioenergetics, signaling and manipulation for therapy

Yue Yang et al.

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The clinical symptoms of Parkinson's disease

Sigurlaug Sveinbjornsdottir

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Mitochondrial dysfunction in Parkinson's disease

Anindita Bose et al.

JOURNAL OF NEUROCHEMISTRY (2016)

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Unbiased Metabolomic Investigation of Alzheimer's Disease Brain Points to Dysregulation of Mitochondrial Aspartate Metabolism

Giuseppe Paglia et al.

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Novel Metabolite Biomarkers of Huntington's Disease As Detected by High-Resolution Mass Spectrometry

Stewart F. Graham et al.

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Polyneuropathy in levodopa-treated Parkinson's patients

Karol Szadejko et al.

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Integration of targeted metabolomics and transcriptomics identifies deregulation of phosphatidylcholine metabolism in Huntington's disease peripheral blood samples

Anastasios Mastrokolias et al.

METABOLOMICS (2016)

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Metabolic Biomarkers and Neurodegeneration: A Pathway Enrichment Analysis of Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis

Medi Kori et al.

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY (2016)

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Branched-Chain Amino Acids as New Biomarkers of Major Depression - A Novel Neurobiology of Mood Disorder

Andreas Baranyi et al.

PLOS ONE (2016)

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Can Ketones Help Rescue Brain Fuel Supply in Later Life? Implications for Cognitive Health during Aging and the Treatment of Alzheimer's Disease

Stephen C. Cunnane et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2016)

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Association between Oxidative DNA Damage and Risk of Colorectal Cancer: Sensitive Determination of Urinary 8-Hydroxy-2′-deoxyguanosine by UPLC-MS/MS Analysis

Cheng Guo et al.

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Post-translational modification of α-synuclein in Parkinson's disease

Paul J. Barrett et al.

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Metabolite profiling for the identification of altered metabolic pathways in Alzheimer's disease

Raul Gonzalez-Dominguez et al.

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Parkinson's disease

Lorraine V. Kalia et al.

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Huntington Disease Pathogenesis and Treatment

Praveen Dayalu et al.

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White Matter Lipids as a Ketogenic Fuel Supply in Aging Female Brain: Implications for Alzheimer's Disease

Lauren P. Klosinski et al.

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S-Nitrosylation in Alzheimer's disease

Qing-Fei Zhao et al.

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A systems-level misunderstanding: the plasma metabolome in Huntington's disease

Herminia D. Rosas et al.

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Influence of serum uric acid levels on prognosis and survival in amyotrophic lateral sclerosis: a meta-analysis

Alon Abraham et al.

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Lysophosphatidylcholine and Amide as Metabolites for Detecting Alzheimer Disease Using Ultrahigh-Performance Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry-Based Metabonomics

Yu Cui et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2014)

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Metabolism in HD: Still a Relevant Mechanism?

Wenzhen Duan et al.

MOVEMENT DISORDERS (2014)

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Treatment of Huntington's Disease

Samuel Frank

NEUROTHERAPEUTICS (2014)

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Dopamine Reduction in the Substantia Nigra of Parkinson's Disease Patients Confirmed by In Vivo Magnetic Resonance Spectroscopic Imaging

Adriane Groeger et al.

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Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes

Towfique Raj et al.

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Shared Mechanisms of Neurodegeneration in Alzheimer's Disease and Parkinson's Disease

Anmu Xie et al.

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Increased 3-Hydroxykynurenine serum concentrations differentiate Alzheimer's disease patients from controls

Markus J. Schwarz et al.

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE (2013)

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Calcium-Regulation of Mitochondrial Respiration Maintains ATP Homeostasis and Requires ARALAR/AGC1-Malate Aspartate Shuttle in Intact Cortical Neurons

Irene Llorente-Folch et al.

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Properties of native brain α-synuclein Reply

Tim Bartels et al.

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Mitochondrial dysfunction and oxidative stress in Parkinson's disease

Sudhakar Raja Subramaniam et al.

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Meta-Analysis of Early Nonmotor Features and Risk Factors for Parkinson Disease

Alastair J. Noyce et al.

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Advantages and disadvantages of PET and SPECT in a busy clinical practice

Timothy M. Bateman

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Network Organization of the Huntingtin Proteomic Interactome in Mammalian Brain

Dyna I. Shirasaki et al.

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Association of COMT, MTHFR, and SLC19A1(RFC-1) polymorphisms with homocysteine blood levels and cognitive impairment in Parkinson's disease

Monika Bialecka et al.

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Diurnal Fluctuation in Histidine Decarboxylase Expression, the Rate Limiting Enzyme for Histamine Production, and Its Disorder in Neurodegenerative Diseases

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Cerebral amyloid angiopathy in the elderly

Anand Viswanathan et al.

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Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation

Mireille Belanger et al.

CELL METABOLISM (2011)

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HD CAG-correlated gene expression changes support a simple dominant gain of function

Jessie C. Jacobsen et al.

HUMAN MOLECULAR GENETICS (2011)

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Ubiquitin-dependent mitochondrial protein degradation

Jin-Mi Heo et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2011)

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Development of biomarkers for Huntington's disease

David W. Weir et al.

LANCET NEUROLOGY (2011)

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Serum levels of N-acetylaspartate in Huntington's disease: Preliminary results

Maddalena Ruggieri et al.

MOVEMENT DISORDERS (2011)

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Histamine in the regulation of wakefulness

Mahesh M. Thakkar

SLEEP MEDICINE REVIEWS (2011)

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DISABILITY AND PROGRESSION IN PARKINSON'S DISEASE

Reijo J. Marttila et al.

ACTA NEUROLOGICA SCANDINAVICA (2010)

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Decreased plasma alanine and isoleucine in Huntington's disease

R. Reilmann et al.

ACTA NEUROLOGICA SCANDINAVICA (2010)

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Dynamic regulation of mitochondrial fission through modification of the dynamin-related protein Drp1

Chuang-Rung Chang et al.

MITOCHONDRIAL RESEARCH IN TRANSLATIONAL MEDICINE (2010)

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The dysregulation of intracellular calcium in Alzheimer disease

Charlene Supnet et al.

CELL CALCIUM (2010)

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Phosphorylation Status of Pyruvate Dehydrogenase Distinguishes Metabolic Phenotypes of Cultured Rat Brain Astrocytes and Neurons

Nader D. Halim et al.

GLIA (2010)

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Regulation of inflammasome activity

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Altered brain mitochondrial metabolism in healthy aging as assessed by in vivo magnetic resonance spectroscopy

Fawzi Boumezbeur et al.

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Blood levels of kynurenines, interleukin-23 and soluble human leucocyte antigen-G at different stages of Huntington's disease

Caroline M. Forrest et al.

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The Contribution of Blood Lactate to Brain Energy Metabolism in Humans Measured by Dynamic 13C Nuclear Magnetic Resonance Spectroscopy

Fawzi Boumezbeur et al.

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Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

Marta Martinez-Vicente et al.

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Glycogen metabolism Metabolic coupling between astrocytes and neurons

Eduardo E. Benarroch

NEUROLOGY (2010)

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Levels of reduced and oxidized coenzymeQ-10 and 8-hydroxy-2′-deoxyguanosine in the cerebrospinal fluid of patients with living Parkinson's disease demonstrate that mitochondrial oxidative damage and/or oxidative DNA damage contributes to the neurodegenerative process

Chiaki Isobe et al.

NEUROSCIENCE LETTERS (2010)

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Indoleamine 2,3-dioxygenase and 3-hydroxy-kynurenine modifications are found in the neuropathology of Alzheimer's disease

David J. Bonda et al.

REDOX REPORT (2010)

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Insulin signaling meets mitochondria in metabolism

Zhiyong Cheng et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2010)

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Mutant Huntingtin induces activation of the Bcl-2/adenovirus E1B 19-kDa interacting protein (BNip3)

J. Sassone et al.

CELL DEATH & DISEASE (2010)

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Serum uric acid levels in patients with Parkinson's disease: Their relationship to treatment and disease duration

Elisabeth Andreadou et al.

CLINICAL NEUROLOGY AND NEUROSURGERY (2009)

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Wild-type but not mutant huntingtin modulates the transcriptional activity of liver X receptors

M. Futter et al.

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Direct measurement of oxidative metabolism in the living brain by microdialysis: a review

H. Ronald Zielke et al.

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The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1

Angel Herrero-Mendez et al.

NATURE CELL BIOLOGY (2009)

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Energy-Efficient Action Potentials in Hippocampal Mossy Fibers

Henrik Alle et al.

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Metabolic profiling of Parkinson's disease: evidence of biomarker from gene expression analysis and rapid neural network detection

Shiek S. S. J. Ahmed et al.

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Complex I deficiency in Parkinson's disease frontal cortex

W. Davis Parker et al.

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A review of Parkinson's disease

C. A. Davie

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Adenosine as a neuromodulator in neurological diseases

Detlev Boison

CURRENT OPINION IN PHARMACOLOGY (2008)

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The itinerary of autophagosomes: From peripheral formation to kiss-and-run fusion with lysosomes

Luca Jahreiss et al.

TRAFFIC (2008)

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The cell-selective neurotoxicity of the Alzheimer's Aβ peptide is determined by surface phosphatidylserine and cytosolic ATP levels.: Membrane binding is required for Aβ toxicity

Olga Simakova et al.

JOURNAL OF NEUROSCIENCE (2007)

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Mitochondrial transport proteins of the brain

D. A. Berkich et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2007)

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Increased oxidative damage and mitochondrial abnormalities in the peripheral blood of Huntington's disease patients

Chiung-Mei Chen et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)

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Early Energy Deficit in Huntington Disease: Identification of a Plasma Biomarker Traceable during Disease Progression

Fanny Mochel et al.

PLOS ONE (2007)

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N-acetylaspartate in the CNS:: From neurodiagnostics to neurobiology

John R. Moffett et al.

PROGRESS IN NEUROBIOLOGY (2007)

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Tauopathies

F. Hernandez et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2007)

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Extracellular NAD and ATP: Partners in immune cell modulation

Friedrich Haag et al.

PURINERGIC SIGNALLING (2007)

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Mitochondrial Aβ:: A potential cause of metabolic dysfunction in Alzheimer's disease

Xi Chen et al.

IUBMB LIFE (2006)

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Seeing is believing: neuroimaging adds to our understanding of cerebral pathology

Gary W. Small et al.

CURRENT OPINION IN PSYCHIATRY (2006)

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AMP-activated protein kinase signaling in metabolic regulation

Yun Chau Long et al.

JOURNAL OF CLINICAL INVESTIGATION (2006)

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Huntington disease patients and transgenic mice have similar pro-catabolic serum metabolite profiles

BR Underwood et al.

BRAIN (2006)

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Oxidative stress promotes mutant huntingtin aggregation and mutant huntingtin-dependent cell death by mimicking proteasomal malfunction

A Goswami et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)

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Article Biochemical Research Methods

Metabolic characterization of the R6/2 transgenic mouse model of Huntington's disease by high-resolution MAS 1H NMR spectroscopy

TA Tsang et al.

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Genome-wide expression profiling of human blood reveals biomarkers for Huntington's disease

F Borovecki et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

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Monocarboxylate transporters in the central nervous system: distribution, regulation and function

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Glutathione metabolism and its implications for health

GY Wu et al.

JOURNAL OF NUTRITION (2004)

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Idiopathic Parkinson's disease:: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen

H Braak et al.

JOURNAL OF NEURAL TRANSMISSION (2003)

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Dichloroacetate effects on glucose and lactate oxidation by neurons and astroglia in vitro and on glucose utilization by brain in vivo

Y Itoh et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

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