Journal
METABOLITES
Volume 13, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/metabo13030426
Keywords
sphingolipids; redox; reactive oxygen species; nitric oxide; hydrogen sulfide; hypoxia
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Redox-active mediators are powerful molecules regulating cellular dynamics and gene expression. Reactive oxygen species (ROS), and gasotransmitters such as NO, CO, and H2S, are key mediators, along with sphingolipid molecules. Cross-regulation between redox mediators and sphingolipids influences cell fate and organ function. This review highlights the effects of redox-active mediators on sphingolipid signaling, metabolism, and their impact on pathophysiological processes.
Redox-active mediators are now appreciated as powerful molecules to regulate cellular dynamics such as viability, proliferation, migration, cell contraction, and relaxation, as well as gene expression under physiological and pathophysiological conditions. These molecules include the various reactive oxygen species (ROS), and the gasotransmitters nitric oxide (NO center dot), carbon monoxide (CO), and hydrogen sulfide (H2S). For each of these molecules, direct targets have been identified which transmit the signal from the cellular redox state to a cellular response. Besides these redox mediators, various sphingolipid species have turned out as highly bioactive with strong signalling potential. Recent data suggest that there is a cross-regulation existing between the redox mediators and sphingolipid molecules that have a fundamental impact on a cell's fate and organ function. This review will summarize the effects of the different redox-active mediators on sphingolipid signalling and metabolism, and the impact of this cross-talk on pathophysiological processes. The relevance of therapeutic approaches will be highlighted.
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