4.6 Article

Liquid Chromatography-Tandem Mass Spectrometry Method for Detection and Quantification of Meloxicam and 5′-Carboxymeloxicam in Oral Fluid Samples

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

Simultaneous separation of naproxen and 6-O-desmethylnaproxen metabolite in saliva samples by liquid chromatography-tandem mass spectrometry: Pharmacokinetic study of naproxen alone and associated with esomeprazol-Results

Gabriela Moraes Oliveira et al.

Summary: After analyzing samples from volunteers who took naproxen alone or in combination with esomeprazole, it was found that the combination took longer to reach the maximum concentration, had a longer elimination time, and lower maximum concentrations compared to naproxen alone. The AUC values and clearance rates also differed between the two situations.

PLOS ONE (2022)

Article Biochemistry & Molecular Biology

Detection and quantification of prostaglandin E2 in saliva by liquid chromatography-tandem mass spectrometry using microextraction by packed sorbent

Gabriela Moraes Oliveira et al.

PROSTAGLANDINS & OTHER LIPID MEDIATORS (2022)

Article Biochemistry & Molecular Biology

CYP2C9 Polymorphism Influence in PK/PD Model of Naproxen and 6-O-Desmethylnaproxen in Oral Fluid

Gabriela Moraes Oliveira et al.

Summary: The present study aimed to investigate the impact of polymorphisms in CYP2C9 on the PK/PD parameters of the nonsteroidal anti-inflammatory drug naproxen. A LC-MS/MS method was developed to determine the concentrations of naproxen and its metabolite in oral fluid, and significant differences were observed in the PK parameters of naproxen in relation to CYP2C9 allelic variations. There were no significant differences in the PK parameters of the main metabolite, while the analysis of PGE(2) showed higher levels in the mutated group. The study highlights the relevance of CYP2C9 allelic variations in the PK of naproxen and its main metabolite.

METABOLITES (2022)

Review Biochemistry & Molecular Biology

Analysis of Different Methods of Extracting NSAIDs in Biological Fluid Samples for LC-MS/MS Assays: Scoping Review

Viviane Silva Siqueira Sandrin et al.

Summary: This study aimed to systematically investigate and analyze different drug extraction methods for Liquid Chromatography in Mass Spectrometry assays (LC-MS/MS), focusing on non-steroidal anti-inflammatory drugs in biological fluid samples. Through a comprehensive search and evaluation of literature, it was found that liquid-liquid extraction (LLE) and solid-phase extraction (SPE) were the main methods used. Additionally, modifications of these traditional techniques were also validated for use in LC-MS/MS. The study suggests that future research should explore more ecological, economic, and sustainable extraction approaches.

METABOLITES (2022)

Article Chemistry, Analytical

Determination of Third-Generation Synthetic Cannabinoids in Oral Fluids

Aitor Sorribes-Soriano et al.

Summary: A method for determining synthetic cannabinoids in oral fluid samples has been developed using a MEPS-GC-MS procedure, demonstrating high potential for semi-automated, selective, and sensitive detection. The study evaluated five synthetic cannabinoids as model compounds, showing high recoveries and sensitivity, with potential for future application in oral fluid samples.

JOURNAL OF ANALYTICAL TOXICOLOGY (2021)

Article Chemistry, Medicinal

Physiologically based pharmacokinetic (PBPK) modeling of meloxicam in different CYP2C9 genotypes

Chang-Keun Cho et al.

Summary: The study aimed to develop and validate a physiologically based pharmacokinetic (PBPK) model of meloxicam related to CYP2C9 genetic polymorphism, successfully simulating drug metabolism in different genotypes. The predicted exposures of meloxicam in CYP2C9*1/*3, CYP2C9*1/*13, and CYP2C9*3/*3 genotypes were increased compared to CYP2C9*1/*1 genotype. Through optimization of meloxicam dosing in different genotypes, the study is expected to contribute to reducing the risk of adverse events associated with meloxicam.

ARCHIVES OF PHARMACAL RESEARCH (2021)

Article Chemistry, Medicinal

Physiologically based pharmacokinetic (PBPK) modeling for prediction of celecoxib pharmacokinetics according to CYP2C9 genetic polymorphism

Young-Hoon Kim et al.

Summary: Celecoxib, a drug commonly used for arthritis and pain, is metabolized by CYP2C9 genetic polymorphism. A PBPK model was developed to predict the pharmacokinetics of Celecoxib based on different genotypes of subjects. The study shows the potential for personalized dosing of Celecoxib using genetic information and contributes to precision medicine.

ARCHIVES OF PHARMACAL RESEARCH (2021)

Article Biochemical Research Methods

Using a stable isotope-labeled internal standard for liquid chromatography-tandem mass spectrometry quantitation of meloxicam in human plasma

Cuijiao Zhan et al.

Summary: The study developed and validated a highly efficient method for detecting meloxicam in human plasma, using stable isotope-labeled internal standard. The method was fully validated for specificity, sensitivity, accuracy, and other parameters, providing a reliable basis for pharmacokinetic studies of meloxicam in healthy Chinese volunteers. Key pharmacokinetic parameters were determined after a single dose administration of meloxicam.

BIOMEDICAL CHROMATOGRAPHY (2021)

Article Pharmacology & Pharmacy

An Evidence-Based Framework for Evaluating Pharmacogenomics Knowledge for Personalized Medicine

Michelle Whirl-Carrillo et al.

Summary: Clinical annotations in PharmGKB summarize the association between variant-drug pairs and are assigned a level of evidence. To ensure consistency and transparency, a scoring system has been developed to automate LOE assignment. This system improves the quality and reliability of clinical annotations.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2021)

Article Biochemical Research Methods

Microextraction approaches for bioanalytical applications: An overview

Mohamed Abdel-Rehim et al.

JOURNAL OF CHROMATOGRAPHY A (2020)

Review Pharmacology & Pharmacy

Application of Pharmacokinetic-Pharmacodynamic Modeling in Drug Delivery: Development and Challenges

Huixi Zou et al.

FRONTIERS IN PHARMACOLOGY (2020)

Article Biochemistry & Molecular Biology

DrugBank 5.0: a major update to the DrugBank database for 2018

David S. Wishart et al.

NUCLEIC ACIDS RESEARCH (2018)

Article Biochemical Research Methods

Facile derivatization of ultratrace carboxylic acids in saliva for quantification by HPLC-MS/MS

Chao Guo et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2018)

Review Pharmacology & Pharmacy

Meloxicam in the management of post-operative pain: Narrative review

Alex Bekker et al.

JOURNAL OF ANAESTHESIOLOGY CLINICAL PHARMACOLOGY (2018)

Article Biochemical Research Methods

Green approaches in sample preparation of bioanalytical samples prior to chromatographic analysis

Olga Filippou et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2017)

Article Chemistry, Medicinal

Pharmacokinetic and pharmacodynamic evaluation according to absorption differences in three formulations of ibuprofen

Dongseong Shin et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2017)

Article Dentistry, Oral Surgery & Medicine

Effective method for the detection of piroxicam in human plasma using HPLC

Adriana Maria Calvo et al.

BRAZILIAN ORAL RESEARCH (2016)

Review Pharmacology & Pharmacy

PBPK modeling and simulation in drug research and development

Xiaomei Zhuang et al.

ACTA PHARMACEUTICA SINICA B (2016)

Article Anesthesiology

COX-2 Inhibition: What We Learned-A Controversial Update on Safety Data

Jeffrey A. Katz

PAIN MEDICINE (2013)

Article Biochemical Research Methods

Solvent-free microextraction techniques in gas chromatography

Jens Laaks et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2012)

Editorial Material Pharmacology & Pharmacy

Pharmacogenomics Knowledge for Personalized Medicine

M. Whirl-Carrillo et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2012)

Article Medicine, Research & Experimental

Saliva versus Plasma Pharmacokinetics: Theory and Application of a Salivary Excretion Classification System

Nasir Idkaidek et al.

MOLECULAR PHARMACEUTICS (2012)

Review Pharmacology & Pharmacy

Pharmacogenetics of analgesics: toward the individualization of prescription

Victoria Rollason et al.

PHARMACOGENOMICS (2008)

Article Biochemical Research Methods

Determination of meloxicam in human plasma using a HPLC method with UV detection and its application to a pharmacokinetic study

Jung-Woo Bae et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2007)

Article Dentistry, Oral Surgery & Medicine

Analgesic and anti-inflammatory dose-response relationship of 7.5 and 15 mg meloxicam after lower third molar removal:: a double-blind, randomized, crossover study

A. M. Calvo et al.

INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY (2007)

Article Biochemical Research Methods

Determination of meloxicam in human plasma by liquid chromatography-tandem mass spectrometry following transdermal administration

Yue Yuan et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2007)

Article Pharmacology & Pharmacy

Influence of CYP2C9 genotypes on the pharmacokinetics and pharmacodynamics of piroxicam

JA Perini et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2005)

Article Pharmacology & Pharmacy

CYP2C9 genotypes and the pharmacokinetics of tenoxicam in Brazilians

R Vianna-Jorge et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2004)