HPV and Cervical Cancer: A Review of Epidemiology and Screening Uptake in the UK

Cervical cancer is the fourth most common malignancy in females worldwide, and a leading cause of death in the United Kingdom (UK). The human papillomavirus (HPV) is the strongest risk factor for developing cervical intraepithelial neoplasia and cancer. Across the UK, the national HPV immunisation programme, introduced in 2008, has been successful in protecting against HPV-related infections. Furthermore, the National Health Service (NHS) implemented the cytology-based cervical cancer screening service to all females aged 25 to 64, which has observed a decline in cervical cancer incidence. In the UK, there has been an overall decline in age-appropriate coverage since April 2010. In 2019, the COVID-19 pandemic disrupted NHS cancer screening and immunisation programmes, leading to a 6.8% decreased uptake of cervical cancer screening from the previous year. Engagement with screening has also been associated with social deprivation. In England, incidence rates of cervical cancer were reported to be 65% higher in the most deprived areas compared to the least, with lifestyle factors such as cigarette consumption contributing to 21% of cervical cancer cases. In this article, we provide an update on the epidemiology of cervical cancer, and HPV pathogenesis and transmission, along with the current prevention programmes within the NHS.

Automated summary

Cervical cancer is a common malignancy in females worldwide and a leading cause of death in the UK, with HPV being the strongest risk factor. The UK has implemented successful national HPV immunisation and cytology-based cervical cancer screening services. However, there has been a decline in age-appropriate coverage since 2010 and the COVID-19 pandemic disrupted screening and immunisation programmes. Socioeconomic factors and lifestyle choices also contribute to the incidence of cervical cancer. This article provides an update on cervical cancer epidemiology, HPV pathogenesis and transmission, and prevention programmes in the NHS.