Antimicrobial Effects of Lactoferrin against Helicobacter pylori Infection

Article Gastroenterology & Hepatology

Disease trends after Helicobacter pylori eradication based on Japanese nationwide claims and the health check-up database

Kazuhiro Mizukami et al.

Summary: H. pylori eradication therapy reduces the incidence of peptic ulcers and gastritis, but is associated with increased incidence of other chronic diseases.

WORLD JOURNAL OF GASTROENTEROLOGY (2023)

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Review Nutrition & Dietetics

Lactoferrin: A glycoprotein that plays an active role in human health

Xiang Cao et al.

Summary: Lactoferrin (Lf) is a multifunctional glycoprotein found in human and mammalian milk that has various functions including immune regulation, anti-inflammation, antibacterial, antiviral, and antioxidant effects. Its ability to chelate iron and interfere with the cellular receptors of pathogenic microorganisms and their hosts contributes to these functions. Lf is non-toxic and compatible with other supplements, making it widely used in food nutrition, drug carriers, biotechnology, and feed development. This review provides an overview of recent advancements in the structure and physicochemical properties of Lf, as well as clinical studies on human diseases, aiming to serve as a reference for further research and development of Lf-related functional products.

FRONTIERS IN NUTRITION (2023)

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Review Gastroenterology & Hepatology

Efficacy of Helicobacter pylori eradication therapy for functional dyspepsia: updated systematic review and meta-analysis

Alexander C. Ford et al.

Summary: The study suggests that H. pylori eradication therapy can lead to both cure and improvement of symptoms in patients with functional dyspepsia, although the benefit is modest. Successful eradication of H. pylori is associated with a greater effect, but also with more adverse events.

GUT (2022)

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Letter Gastroenterology & Hepatology

Gastrointestinal microbiome and Helicobacter pylori: Eradicate, leave it as it is, or take a personalized benefit-risk approach?

Stanislav Sitkin et al.

Summary: Helicobacter pylori (H. pylori) is a potential human pathogen causing diseases like gastric ulcers and cancer, but it can also have beneficial effects by protecting against certain allergic and autoimmune disorders. Eradication of H. pylori may lead to dysbiosis of gut microbiota, which can be detrimental to some patients.

WORLD JOURNAL OF GASTROENTEROLOGY (2022)

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Article Agriculture, Dairy & Animal Science

Protective effects of recombinant lactoferrin with different iron saturations on enteritis injury in young mice

L. L. Fan et al.

Summary: Apo-LF can significantly alleviate enteritis injury caused by LPS through regulating the PPAR-gamma/ PFKFB3/NF-kappa B inflammatory pathway.

JOURNAL OF DAIRY SCIENCE (2022)

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Article Gastroenterology & Hepatology

Management of Helicobacter pylori infection: the Maastricht VI/Florence consensus report

Peter Malfertheiner et al.

Summary: Helicobacter pylori infection is recognized as an infectious disease and requires optimized management to prevent complications and gastric cancer. Continuous updates in treatment strategies and testing methods are necessary due to rising antibiotic resistance and the impact on gut microbiota.

GUT (2022)

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Article Gastroenterology & Hepatology

Declining trends of prevalence of Helicobacter pylori infection and incidence of gastric cancer in Taiwan: An updated cross-sectional survey and meta-analysis

Mei-Jyh Chen et al.

Summary: The prevalence of Helicobacter pylori infection has declined in Taiwan, which is correlated with the declining trends of age-standardized incidence and mortality of gastric cancer.

HELICOBACTER (2022)

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Review Gastroenterology & Hepatology

Vonoprazan-containingHelicobacter pyloritriple therapies contribution to global antimicrobial resistance

David Y. Graham et al.

Summary: The combination therapy of amoxicillin and proton pump inhibitor for H. pylori treatment is not highly effective due to the inability to maintain a high intragastric pH. Clarithromycin resistance has led to treatment failures, impacting the efficacy of various dual and triple therapies. Optimized vonoprazan-amoxicillin dual therapy has shown to achieve cure rates >= 95%, highlighting the importance of developing antimicrobial stewardship practices for efficient treatment strategies without overuse of antibiotics.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2021)

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Review Biochemistry & Molecular Biology

Diverse Mechanisms of Antimicrobial Activities of Lactoferrins, Lactoferricins, and Other Lactoferrin-Derived Peptides

Spela Gruden et al.

Summary: Lactoferrins and their derivatives have important protective roles in the body, including antimicrobial, antitumor, anti-inflammatory, immunomodulatory, and antioxidant activities. While their antimicrobial activity has been extensively studied, the specific mechanisms behind their actions are still not fully understood.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Cell Biology

Helicobacter pylori Virulence Factors-Mechanisms of Bacterial Pathogenicity in the Gastric Microenvironment

Jacek Baj et al.

Summary: Gastric cancer is a prevalent malignancy worldwide and ranks as the fourth leading cause of cancer-related deaths. The pathogenesis of gastric cancer involves the interaction between genetic and environmental factors, with Helicobacter pylori infection playing a major role. Understanding the mechanisms of H. pylori pathogenicity is crucial for developing eradication strategies to prevent carcinogenesis.

CELLS (2021)

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Article Gastroenterology & Hepatology

Adverse Event Profile During the Treatment of Helicobacter pylori: A Real-World Experience of 22,000 Patients From the European Registry on H. pylori Management (Hp-EuReg)

Olga P. Nyssen et al.

Summary: Helicobacter pylori eradication treatment often leads to mild and short-lived adverse events, but these events usually do not significantly impact treatment compliance.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2021)

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Article Gastroenterology & Hepatology

The effect of previous eradication failure on antibiotic resistance of Helicobacter pylori: A retrospective study over 8 years in Beijing

Si-Yu Li et al.

Summary: High primary and secondary resistance rates of clarithromycin, metronidazole, moxifloxacin, and levofloxacin were found in Beijing. Multiple-resistance patterns were common after treatment failure, while resistance rates of amoxicillin and tetracycline remained low and stable.

HELICOBACTER (2021)

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Article Microbiology

An Overview of Helicobacter pylori Survival Tactics in the Hostile Human Stomach Environment

Yi Ying Cheok et al.

Summary: Helicobacter pylori, armed with unique virulence factors, is capable of surviving in the harsh stomach environment and causing inflammation and tissue damage, leading to gastric cancer. The bacterium not only establishes colonization in the stomach, but also manipulates the host immune system to ensure long-term survival.

MICROORGANISMS (2021)

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Article Biochemistry & Molecular Biology

The Innate Immune Glycoprotein Lactoferrin Represses the Helicobacter pylori cag Type IV Secretion System

Jacky Lu et al.

Summary: Chronic infection with Helicobacter pylori increases the risk of gastric diseases, including gastric cancer, with strains encoding the cag T4SS system being associated with more serious disease outcomes. The presence of nutrient iron can modulate the activity of the T4SS and biogenesis of T4SS pili, with lactoferrin exerting antimicrobial activity against H. pylori under iron-limited conditions. Additionally, culturing H. pylori with holo-lactoferrin prior to co-culture with gastric epithelial cells can lead to repression of the cag T4SS activity and decreased biogenesis of T4SS pili.

CHEMBIOCHEM (2021)

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Review Gastroenterology & Hepatology

The prevention of gastric cancer by Helicobacter pylori eradication

Erick A. Argueta et al.

Summary: Studies have shown that eradication of Helicobacter pylori can reduce approximately 50% of sporadic gastric cancer cases. Screening first-degree relatives of gastric cancer cases, preventing metachronous neoplasia after resection of early gastric cancer, and implementing population-based screen and treatment programs in high prevalence areas have all shown similar benefits. Screening for H. pylori, especially among at-risk minority groups, may help prevent gastric cancer even in countries with lower prevalence rates like the United States.

CURRENT OPINION IN GASTROENTEROLOGY (2021)

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Article Gastroenterology & Hepatology

Efficacy of Lactoferrin with Standard Triple Therapy or Sequential Therapy for Helicobacter pylori Eradication: A Randomized Controlled Trial

Fahmy H. Hablass et al.

Summary: The addition of bovine lactoferrin to anti-H. pylori treatment regimens can increase the success rate of eradication, especially when combined with sequential therapy. Bovine lactoferrin and the presence of endoscopic corpus gastritis are independent predictors for successful eradication of H. pylori.

TURKISH JOURNAL OF GASTROENTEROLOGY (2021)

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Review Biochemistry & Molecular Biology

Lactoferrin: Major Physiological Functions and Applications

Liyuan Hao et al.

CURRENT PROTEIN & PEPTIDE SCIENCE (2019)

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Review Oncology

Effect of Helicobacter pylori eradication on the incidence of gastric cancer: a systematic review and meta-analysis

Kentaro Sugano

GASTRIC CANCER (2019)

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Article Gastroenterology & Hepatology

Guidelines for the management of Helicobacter pylori infection in Japan: 2016 Revised Edition

Mototsugu Kato et al.

HELICOBACTER (2019)

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Review Medicine, Research & Experimental

Multifunctional capacity and therapeutic potential of lactoferrin

Luis Moreno-Exposito et al.

LIFE SCIENCES (2018)

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Review Microbiology

Helicobacter pylori Biofilm Formation and Its Potential Role in Pathogenesis

Skander Hathroubi et al.

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2018)

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Article Multidisciplinary Sciences

Molecular mechanism of inhibitory effects of bovine lactoferrin on the growth of oral squamous cell carcinoma

Chanbora Chea et al.

PLOS ONE (2018)

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Article Medicine, General & Internal

The impact of Helicobacter pylori infection, eradication therapy and probiotic supplementation on gut microenvironment homeostasis: An open-label, randomized clinical trial

Luyi Chen et al.

EBIOMEDICINE (2018)

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Review Medicine, General & Internal

Association of CagA EPIYA-D or EPIYA-C phosphorylation sites with peptic ulcer and gastric cancer risks A meta-analysis

Qiuping Li et al.

MEDICINE (2017)

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Review Gastroenterology & Hepatology

Population screening and treatment of Helicobacter pylori infection

Anthony O'Connor et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2017)

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Article Neurosciences

Bovine lactoferrin reduces extra-territorial facial allodynia/hyperalgesia following a trigeminal nerve injury in the rat

Kayo Horie et al.

BRAIN RESEARCH (2017)

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Review Gastroenterology & Hepatology

ACG Clinical Guideline: Treatment of Helicobacter pylori Infection

William D. Chey et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2017)

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Article Gastroenterology & Hepatology

The Toronto Consensus for the Treatment of Helicobacter pylori Infection in Adults

Carlo A. Fallone et al.

GASTROENTEROLOGY (2016)

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Article Gastroenterology & Hepatology

Vonoprazan, a novel potassium-competitive acid blocker, as a component of first-line and second-line triple therapy for Helicobacter pylori eradication: a phase III, randomised, double-blind study

Kazunari Murakami et al.

GUT (2016)

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Article Medicine, Research & Experimental

Recombinant human lactoferrin enhances the efficacy of triple therapy in mice infected with Helicobacter pylori

Yuping Yuan et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2015)

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Review Chemistry, Multidisciplinary

Immunomodulatory effects of lactoferrin

Tania Siqueiros-Cendon et al.

ACTA PHARMACOLOGICA SINICA (2014)

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Review Gastroenterology & Hepatology

Management of Helicobacter pylori infection-the Maastricht IV/ Florence Consensus Report

Peter Malfertheiner et al.

GUT (2012)

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Article Immunology

Unique Host Iron Utilization Mechanisms of Helicobacter pylori Revealed with Iron-Deficient Chemically Defined Media

Olga Senkovich et al.

INFECTION AND IMMUNITY (2010)

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Review Medicine, General & Internal

Prevention of Gastric Cancer by Helicobacter pylori Eradication

Masahiro Asaka et al.

INTERNAL MEDICINE (2010)

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Article Biochemistry & Molecular Biology

Siderophore-mediated iron acquisition in the staphylococci

Federico C. Beasley et al.

JOURNAL OF INORGANIC BIOCHEMISTRY (2010)

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Article Gastroenterology & Hepatology

Meta-analysis: efficacy of bovine lactoferrin in Helicobacter pylori eradication

A. Sachdeva et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2009)

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Article Biophysics

The Structural Basis for the Prevention of Nonsteroidal Antiinflammatory Drug-Induced Gastrointestinal Tract Damage by the C-Lobe of Bovine Colostrum Lactoferrin

Rafia Mir et al.

BIOPHYSICAL JOURNAL (2009)

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Article Immunology

Attenuation of massive cytokine response to the staphylococcal enterotoxin B superantigen by the innate immunomodulatory protein lactoferrin

J. L. Hayworth et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2009)

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Article Gastroenterology & Hepatology

Meta-Analysis: The Effect of Supplementation with Lactoferrin on Eradication Rates and Adverse Events During Helicobacter pylori Eradication Therapy

Jian Zou et al.

HELICOBACTER (2009)

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Article Microbiology

Annual Change of Primary Resistance to Clarithromycin among Helicobacter pylori Isolates from 1996 through 2008 in Japan

Noriyuki Horiki et al.

HELICOBACTER (2009)

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Article Biotechnology & Applied Microbiology

Lactoferrin and desferrioxamine are ineffective in the treatment of Helicobacter pylori infection and may enhance H-pylori growth and gastric inflammation in mice

H. Q. Huynh et al.

LETTERS IN APPLIED MICROBIOLOGY (2009)

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Article Gastroenterology & Hepatology

Helicobacter pylori eradication with either quadruple regimen with lactoferrin or levofloxacin-based triple therapy:: A multicentre study

A. Zullo et al.

DIGESTIVE AND LIVER DISEASE (2007)

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Article Gastroenterology & Hepatology

Helicobacter pylori eradication:: A randomized prospective study of triple therapy versus triple therapy plus lactoferrin and probiotics

Nicola de Bortoli et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2007)

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Review Microbiology

Pathogenesis of Helicobacter pylori infection

Johannes G. Kusters et al.

CLINICAL MICROBIOLOGY REVIEWS (2006)

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Article Gastroenterology & Hepatology

Bovine lactoferrin for Helicobacter pylori eradication:: an open, randomized, multicentre study

F Di Mario et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2006)

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Article Gastroenterology & Hepatology

Quadruple therapy with lactoferrin for Helicobacter pylori eradication:: A randomised, multicentre study

A Zullo et al.

DIGESTIVE AND LIVER DISEASE (2005)

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Article Gastroenterology & Hepatology

Helicobacter pylori cag-type IV secretion systems facilitates corpus colonization to induce precancerous conditions in Mongolian gerbils

G Rieder et al.

GASTROENTEROLOGY (2005)

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Article Multidisciplinary Sciences

The spatial orientation of Helicobacter pylori in the gastric mucus

S Schreiber et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

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Review Biochemistry & Molecular Biology

Lactoferrin - a multifunctional protein with antimicrobial properties

S Farnaud et al.

MOLECULAR IMMUNOLOGY (2003)

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Article Gastroenterology & Hepatology

Use of bovine lactoferrin for Helicobacter pylori eradication

F Di Mario et al.

DIGESTIVE AND LIVER DISEASE (2003)

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Article Gastroenterology & Hepatology

Use of lactoferrin for Helicobacter pylori eradication -: Preliminary results

F Di Mario et al.

JOURNAL OF CLINICAL GASTROENTEROLOGY (2003)

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Article Multidisciplinary Sciences

A component of innate immunity prevents bacterial biofilm development

PK Singh et al.

NATURE (2002)

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Article Infectious Diseases

Suppressive effect of Lactobacillus gasseri OLL 2716 (LG21) on Helicobacter pylori infection in humans

I Sakamoto et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2001)

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Article Pharmacology & Pharmacy

Recombinant human lactoferrin is effective in the treatment of Helicobacter felis-infected mice

EJ Dial et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2000)

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Antimicrobial Effects of Lactoferrin against Helicobacter pylori Infection

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