Journal
LEUKEMIA RESEARCH
Volume 49, Issue -, Pages 7-12Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2016.07.006
Keywords
Multiple myeloma; UPR; IRE1α XBP1s; Therapy; Prognosis
Categories
Funding
- Tianjin Science and Technology Support Program [13ZCZCSY20300]
- Planned scientific research program of Tianjin Municipal Education Commission [20140112]
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Multiple myeloma (MM), which arises from the uncontrolled proliferation of malignant plasma cells, is the second most commonly diagnosed hematologic malignancy in the United States. Despite the development and application of novel drugs and autologous stem cell transplantation (ASCT), MM remains an incurable disease and patients become more prone to MM relapse and drug resistance. It is extremely urgent to find novel targeted therapy for MM. To date, the classic signaling pathways underlying MM have included the RAS/RAF/MEK/ERK pathway, the JAK-STAT3 pathway, the PI3K/Akt pathway and the NF-KB pathway. The IRE1 alpha-XBP1 signaling pathway is currently emerging as an important pathway involved in the development of MM. Moreover, it is closely associated with the effect of MM treatment and its prognosis. All these findings indicate that the IRE1 alpha-XBP1 pathway can be a potential treatment target. Herein, we investigate the relationship between the IRE1 alpha-XBP1 pathway and MM and discuss the functions of IRE1 alpha-XBP1-targeted drugs in the treatment of MM. (C) 2016 Elsevier Ltd. All rights reserved.
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