New progress in the role of microRNAs in the diagnosis and prognosis of triple negative breast cancer

Triple negative breast cancer is distinguished by its high malignancy, aggressive invasion, rapid progression, easy recurrence, and distant metastases. Additionally, it has a poor prognosis, a high mortality, and is unresponsive to conventional endocrine and targeted therapy, making it a challenging problem for breast cancer treatment and a hotspot for scientific research. Recent research has revealed that certain miRNA can directly or indirectly affect the occurrence, progress and recurrence of TNBC. Their expression levels have a significant impact on TNBC diagnosis, treatment and prognosis. Some miRNAs can serve as biomarkers for TNBC diagnosis and prognosis. This article summarizes the progress of miRNA research in TNBC, discusses their roles in the occurrence, invasion, metastasis, prognosis, and chemotherapy of TNBC, and proposes a treatment strategy for TNBC by interfering with miRNA expression levels.

Automated summary

Triple negative breast cancer (TNBC) is a highly malignant and aggressive form of breast cancer that is difficult to treat. Recent research has shown that certain miRNA can impact the development, progression, and recurrence of TNBC, making them potential biomarkers for diagnosis and prognosis. This article summarizes the progress of miRNA research in TNBC and discusses their roles in various aspects of TNBC, proposing a treatment strategy for TNBC through interfering with miRNA expression levels.