Journal
MICROORGANISMS
Volume 11, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/microorganisms11061562
Keywords
immunocompromise; SARS-CoV-2; variants; protracted infection; B-and T-cell immunity
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Immunocompromised individuals with COVID-19 have higher risk, and studying their disease courses and immune responses is crucial. By analyzing the immune response of an immunocompromised individual with a prolonged SARS-CoV-2 infection, we provide insights into the interplay between B- and T-cell immunity in clearing the virus.
Immunocompromised individuals are at higher risk of developing protracted and severe COVID-19, and understanding individual disease courses and SARS-CoV-2 immune responses in these individuals is of the utmost importance. For more than two years, we followed an immunocompromised individual with a protracted SARS-CoV-2 infection that was eventually cleared in the absence of a humoral neutralizing SARS-CoV-2 antibody response. By conducting an in-depth examination of this individual's immune response and comparing it to a large cohort of convalescents who spontaneously cleared a SARS-CoV-2 infection, we shed light on the interplay between B- and T-cell immunity and how they interact in clearing SARS-CoV-2 infection.
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