4.6 Article

Co-Expression of Transcriptional Regulators and Housekeeping Genes in Streptomyces spp.: A Strategy to Optimize Metabolite Production

Related references

Note: Only part of the references are listed.
Article Plant Sciences

Characterization of the Aminosugar Biosynthetic and Regulatory Genes of Vicenistatin in Monodonata labio-Associated Streptomyces parvus SCSIO Mla-L010

Zhicheng Liang et al.

Summary: Vicenistatin, a potent polyketide antitumor antibiotic, was isolated and its biosynthetic gene cluster was identified from Streptomyces parvus SCSIO Mla-L010. The N-methyltransferase VicG and the positive pathway-specific regulatory gene VicR1 were characterized. The N-demethyl compound 2 exhibited impressive antibacterial activities against various bacteria and reduced cytotoxicity in noncancerous human cell lines.

JOURNAL OF NATURAL PRODUCTS (2022)

Review Environmental Sciences

COVID-19 and antimicrobial resistance: A cross-study

Sidra Ghazali Rizvi et al.

Summary: Antimicrobial resistance is becoming a serious concern due to overuse of antibiotics, exacerbated by the increase in global antibiotic usage during the COVID-19 pandemic. This has led to higher concentrations of residual antibiotics in wastewater, posing a threat to natural water bodies. Urgent measures are needed to curb antibiotic usage and improve wastewater treatment to efficiently remove residual contaminants.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

Article Cell Biology

Volatile Compounds in Actinomycete Communities: A New Tool for Biosynthetic Gene Cluster Activation, Cooperative Growth Promotion, and Drug Discovery

Lorena Cuervo et al.

Summary: This study highlights the importance of discovering new therapeutic alternatives, especially natural compounds that can be used to treat multiresistant pathogens and emerging diseases. The research finds that volatile compounds (VOCs) have the ability to activate biosynthetic pathways of bioactive compounds in Actinomycetes, leading to increased antibiotic production and synthesis of new VOCs. The results demonstrate a novel strategy to exploit the metabolic potential of Actinomycetes and emphasize the significance of studying interactions between different microorganisms sharing the same ecological niche.

CELLS (2022)

Review Infectious Diseases

Antibiotic prescribing in patients with COVID-19: rapid review and meta-analysis

Bradley J. Langford et al.

Summary: The study estimated that approximately three-quarters of patients with COVID-19 receive antibiotic treatment, which is significantly higher than the estimated prevalence of bacterial co-infection. This suggests a potential for high rates of unnecessary antibiotic use in patients with COVID-19.

CLINICAL MICROBIOLOGY AND INFECTION (2021)

Review Biotechnology & Applied Microbiology

Recent Advances in Silent Gene Cluster Activation in Streptomyces

Zhenyu Liu et al.

Summary: This review discusses the commonly used strategies for activating silent BGCs in Streptomyces, focusing on approaches applied in heterologous and native hosts to accelerate the discovery of natural products.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

Article Microbiology

Pan-Genome of the Genus Streptomyces and Prioritization of Biosynthetic Gene Clusters With Potential to Produce Antibiotic Compounds

Carlos Caicedo-Montoya et al.

Summary: This study utilized 121 genome sequences of the genus Streptomyces to estimate genomic diversity and identify potential antibiotic gene clusters. The open pan-genome of Streptomyces was observed, with a high quantity of unique gene families across species. Phylogenetic relationships were described using multiple markers, and 33 biosynthetic gene clusters with antibiotic potential were identified.

FRONTIERS IN MICROBIOLOGY (2021)

Article Microbiology

Complete Genome Analysis of Undecylprodigiosin Pigment Biosynthesizing Marine Streptomyces Species Displaying Potential Bioactive Applications

Chatragadda Ramesh et al.

Summary: Marine Streptomyces species are not fully explored for their pigment molecules and genes. This study reports the genome of Streptomyces sp. BSE6.1, isolated from coastal sediment of the Andaman and Nicobar Islands in India, which carries gene clusters related to the synthesis of various secondary metabolites including undecylprodigiosin. The genome of this strain contains multiple polyketide synthases genes, and the red pigment undecylprodigiosin produced by this strain has potential applications in the food and pharmaceutical industries.

MICROORGANISMS (2021)

Article Microbiology

A Multidisciplinary Approach to Unraveling the Natural Product Biosynthetic Potential of a Streptomyces Strain Collection Isolated from Leaf-Cutting Ants

Ana Ceniceros et al.

Summary: By analyzing the genomes of 12 Streptomyces sp. strains isolated from leaf-cutting ants of the Attini tribe, it was revealed that over half of the predicted biosynthetic gene clusters were strain-specific, indicating the potential for novel compound discovery in this strain collection.

MICROORGANISMS (2021)

Article Biochemistry & Molecular Biology

antiSMASH 6.0: improving cluster detection and comparison capabilities

Kai Blin et al.

Summary: antiSMASH, a tool for detecting biosynthetic gene clusters in microorganisms, has been updated to version 6, which increases the supported cluster types, displays the structure of multi-modular BGCs, adds a new comparison algorithm, allows integration of results from other prediction tools, and improves detection of tailoring enzymes in RiPP clusters.

NUCLEIC ACIDS RESEARCH (2021)

Article Biochemistry & Molecular Biology

Specialized Metabolites from Ribosome Engineered Strains of Streptomyces clavuligerus

Arshad Ali Shaikh et al.

Summary: This study utilized an overexpression strategy in combination with untargeted metabolomics, molecular networking, and in silico analysis to annotate 28 metabolites not previously reported in Streptomyces clavuligerus. The manipulation of frr and rpsL in specific conditions led to the production of commonly found plant compounds in S. clavuligerus, with different metabolite production profiles observed. Known and putative gene clusters associated with the production of observed compounds were discussed, highlighting the potential of combining traditional strain engineering and metabolomics technologies for the rapid discovery of novel natural products.

METABOLITES (2021)

Article Biochemistry & Molecular Biology

BldD, a master developmental repressor, activates antibiotic production in two Streptomyces species

Hao Yan et al.

MOLECULAR MICROBIOLOGY (2020)

Article Biotechnology & Applied Microbiology

Engineering of Streptomyces lividans for heterologous expression of secondary metabolite gene clusters

Yousra Ahmed et al.

MICROBIAL CELL FACTORIES (2020)

Article Biotechnology & Applied Microbiology

Biosynthesis Gene Cluster and Oxazole Ring Formation Enzyme for Inthomycins in Streptomyces sp. Strain SYP-A7193

Shao-Yang Hou et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2020)

Review Microbiology

Antibiotics: past, present and future

Matthew I. Hutchings et al.

CURRENT OPINION IN MICROBIOLOGY (2019)

Article Biochemical Research Methods

Manipulation of two regulatory genes for efficient production of chromomycins in Streptomyces reseiscleroticus

Lei Sun et al.

JOURNAL OF BIOLOGICAL ENGINEERING (2018)

Review Microbiology

Connecting Metabolic Pathways: Sigma Factors in Streptomyces spp.

Di Sun et al.

FRONTIERS IN MICROBIOLOGY (2017)

Review Biotechnology & Applied Microbiology

Regulatory genes and their roles for improvement of antibiotic biosynthesis in Streptomyces

Fengjuan Lu et al.

3 BIOTECH (2017)

Review Biotechnology & Applied Microbiology

Regulatory genes and their roles for improvement of antibiotic biosynthesis in Streptomyces

Fengjuan Lu et al.

3 BIOTECH (2017)

Review Biotechnology & Applied Microbiology

Genetic regulation and manipulation for natural product discovery

Jianwei Chen et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2016)

Article Biochemistry & Molecular Biology

Alteramide B is a microtubule antagonist of inhibiting Candida albicans

Yanjiao Ding et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2016)

Article Microbiology

Bacteriophages as Potential Treatment for Urinary Tract Infections

Wilbert Sybesma et al.

FRONTIERS IN MICROBIOLOGY (2016)

Review Biochemistry & Molecular Biology

Natural products in soil microbe interactions and evolution

Matthew F. Traxler et al.

NATURAL PRODUCT REPORTS (2015)

Review Medicine, General & Internal

Totally drug-resistant tuberculosis and adjunct therapies

S. K. Parida et al.

JOURNAL OF INTERNAL MEDICINE (2015)

Article Biotechnology & Applied Microbiology

Deciphering the Regulon of Streptomyces coelicolor AbrC3, a Positive Response Regulator of Antibiotic Production

Sergio Rico et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2014)

Article Biochemistry & Molecular Biology

Insights into Secondary Metabolism from a Global Analysis of Prokaryotic Biosynthetic Gene Clusters

Peter Cimermancic et al.

Article Biotechnology & Applied Microbiology

An Engineered Strong Promoter for Streptomycetes

Weishan Wang et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2013)

Review Microbiology

Bacteriocins - a viable alternative to antibiotics?

Paul D. Cotter et al.

NATURE REVIEWS MICROBIOLOGY (2013)

Article Biotechnology & Applied Microbiology

Overexpression of metK shows different effects on avermectin production in various Streptomyces avermitilis strains

Xuejin Zhao et al.

WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY (2013)

Review Microbiology

Engineering of regulatory cascades and networks controlling antibiotic biosynthesis in Streptomyces

Juan-Francisco Martin et al.

CURRENT OPINION IN MICROBIOLOGY (2010)

Article Multidisciplinary Sciences

Reverse biological engineering of hrdB to enhance the production of avermectins in an industrial strain of Streptomyces avermitilis

Ying Zhuo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Biochemistry & Molecular Biology

Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans

Sebastian Bergmann et al.

NATURE CHEMICAL BIOLOGY (2007)

Article Pharmacology & Pharmacy

Natural products - The future scaffolds for novel antibiotics?

MS Butler et al.

BIOCHEMICAL PHARMACOLOGY (2006)

Article Biotechnology & Applied Microbiology

AfsR as an integrator of signals that are sensed by multiple serine/threonine kinases in Streptomyces coelicolor A3(2)

S Horinouchi

JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2003)