Journal
LEUKEMIA & LYMPHOMA
Volume 58, Issue 3, Pages 569-577Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10428194.2016.1203432
Keywords
Idiopathic cytopenia of undetermined significance; isolated trisomy 8 (+8); myelodysplastic syndrome; myeloid neoplasms
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The significance of an isolated trisomy 8 (+8) in the diagnosis of myelodysplastic syndrome (MDS) is not well established. It is common in MDS, but is not considered as an MDS-defining abnormality in the absence of morphologic dysplasia. We evaluated two groups of patients with isolated +8 and either low-grade MDS (LG-MDS) or idiopathic cytopenia of undetermined significance (ICUS). At presentation, ICUS patients had a lower platelet count (85.0 vs 163.5 x 10(9) cells/L; p = 0.02), while MDS patients had more frequent incidence of isolated anemia (64% vs 0%, p = 0.007). A subset (36%) of ICUS patients progressed to MDS or AML. These patients presented with more severe neutropenia (0.9 vs 3.1 x 10(3)/mu L, p = 0.01) and a trend toward a higher proportion (> 50%) of+8 metaphases compared to those that did not progress (p = 0.05). Thus, ICUS patients with isolated +8 may progress to MDS and AML and deserve close clinical follow-up.
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