4.6 Article

Mouse Liver-Expressed Shiftless Is an Evolutionarily Conserved Antiviral Effector Restricting Human and Murine Hepaciviruses

Related references

Note: Only part of the references are listed.
Article Virology

Shiftless Restricts Viral Gene Expression and Influences RNA Granule Formation during Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication

William Rodriguez et al.

Summary: SHFL is a protein with antiviral properties that can restrict the replication of multiple viruses. It restricts KSHV replication by targeting the expression of critical viral early genes, and affects RNA stability and granule formation.

JOURNAL OF VIROLOGY (2022)

Article Multidisciplinary Sciences

TRIM26 is a critical host factor for HCV replication and contributes to host tropism

Yisha Liang et al.

Summary: Through a genome-wide CRISPR-Cas9 screening, the study identified E3 ligase TRIM26 as a critical host factor for HCV replication, with its deficiency impairing HCV genome replication. Mechanistic studies revealed that TRIM26 mediates the ubiquitination of HCV-encoded NS5B protein and promotes HCV genome replication, while the unique structure of mouse TRIM26 prevents its support for HCV replication, unlike human TRIM26 which can promote HCV infection.

SCIENCE ADVANCES (2021)

Article Virology

Initial Hepatitis C Virus Infection of Adult Hepatocytes Triggers a Temporally Structured Transcriptional Program Containing Diverse Pro- and Antiviral Elements

Birthe Tegtmeyer et al.

Summary: Transcriptional profiling reveals early and massive dysregulation of gene expression in response to HCV infection in primary human hepatocytes, impacting diverse biological processes. Upregulation of IFN-mediated defense programs in infected cells limits viral replication, while downregulation of translation initiation genes suggests a translational shutoff in host cells. These findings suggest a balance between antiviral and proviral programs in infected cells, leading to potential viral persistence.

JOURNAL OF VIROLOGY (2021)

Article Multidisciplinary Sciences

Shiftless inhibits flavivirus replication in vitro and is neuroprotective in a mouse model of Zika virus pathogenesis

Natasha W. Hanners et al.

Summary: Flaviviruses like Zika virus and West Nile virus can cause severe neuropathology if they invade the central nervous system. The interferon-stimulated gene (ISG) effector Shiftless (SHFL) has been identified as a potent inhibitor of various positive-stranded RNA viruses, including multiple Flaviviridae members, and plays an important role in host protection against Zika virus infection and virus-induced neuropathological disease.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Multidisciplinary Sciences

The short isoform of the host antiviral protein ZAP acts as an inhibitor of SARS-CoV-2 programmed ribosomal frameshifting

Matthias M. Zimmer et al.

Summary: Programmed ribosomal frameshifting (PRF) occurs in many viruses, including SARS-CoV-2, allowing translation of multiple proteins from a single transcript. Here, the authors identify the human short isoform of zinc-finger antiviral protein (ZAP-S) as a direct regulator of PRF in SARS-CoV-2, severely impairing frameshifting and directly interacting with SARS-CoV-2 RNA to interfere with frameshift RNA element folding.

NATURE COMMUNICATIONS (2021)

Article Gastroenterology & Hepatology

Efficient acute and chronic infection of stem cell-derived hepatocytes by hepatitis C virus

Arnaud Carpentier et al.

Article Medicine, Research & Experimental

Animal Models of Hepatitis C Virus Infection

Alexander Ploss et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2020)

Article Infectious Diseases

C19orf66 interrupts Zika virus replication by inducing lysosomal degradation of viral NS3

Yun Wu et al.

PLOS NEGLECTED TROPICAL DISEASES (2020)

Article Multidisciplinary Sciences

Liver-expressed Cd302 and Cr1l limit hepatitis C virus cross-species transmission to mice

Richard J. P. Brown et al.

SCIENCE ADVANCES (2020)

Article Gastroenterology & Hepatology

Status of Direct-Acting Antiviral Therapy for Hepatitis C Virus Infection and Remaining Challenges

Thomas F. Baumert et al.

GASTROENTEROLOGY (2019)

Review Gastroenterology & Hepatology

Global epidemiology and burden of HCV infection and HCV-related disease

Aaron P. Thrift et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2017)

Article Medicine, Research & Experimental

Transcriptional response to hepatitis C virus infection and interferon-alpha treatment in the human liver

Tujana Boldanova et al.

EMBO MOLECULAR MEDICINE (2017)

Review Cell Biology

Zinc-finger proteins in health and disease

Matteo Cassandri et al.

CELL DEATH DISCOVERY (2017)

Article Biochemistry & Molecular Biology

MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets

Sudhir Kumar et al.

MOLECULAR BIOLOGY AND EVOLUTION (2016)

Article Gastroenterology & Hepatology

Hepatitis C virus infects rhesus macaque hepatocytes and simianized mice

Margaret A. Scull et al.

HEPATOLOGY (2015)

Review Immunology

Interferon-Stimulated Genes: A Complex Web of Host Defenses

William M. Schneider et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 32 (2014)

Letter Biochemical Research Methods

Improved vectors and genome-wide libraries for CRISPR screening

Neville E. Sanjana et al.

NATURE METHODS (2014)

Article Multidisciplinary Sciences

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

Ophir Shalem et al.

SCIENCE (2014)

Article Gastroenterology & Hepatology

MicroRNA-221 overexpression accelerates hepatocyte proliferation during liver regeneration

Qinggong Yuan et al.

HEPATOLOGY (2013)

Article Multidisciplinary Sciences

Completion of the entire hepatitis C virus life cycle in genetically humanized mice

Marcus Dorner et al.

NATURE (2013)

Review Biochemical Research Methods

Entry and replication of recombinant hepatitis C viruses in cell culture

Gabrielle Vieyres et al.

METHODS (2013)

Article Multidisciplinary Sciences

Human occludin is a hepatitis C virus entry factor required for infection of mouse cells

Alexander Ploss et al.

NATURE (2009)

Article Multidisciplinary Sciences

Modulation of hepatitis C virus RNA abundance by a liver-specific microRNA

CL Jopling et al.

SCIENCE (2005)

Article Biochemistry & Molecular Biology

Triple decoding of hepatitis C virus RNA by programmed translational frameshifting

JA Choi et al.

MOLECULAR AND CELLULAR BIOLOGY (2003)

Article Multidisciplinary Sciences

Efficient initiation of HCV RNA replication in cell culture

KJ Blight et al.

SCIENCE (2000)