4.7 Article

Enhanced Levels of Peroxisome-Derived H2O2 Do Not Induce Pexophagy but Impair Autophagic Flux in HEK-293 and HeLa Cells

Related references

Note: Only part of the references are listed.
Review Cell Biology

Mitochondria ROS and mitophagy in acute kidney injury

Lianjiu Su et al.

Summary: Mitophagy is a crucial mitochondrial quality control mechanism that removes damaged mitochondria and reactive oxygen species (ROS) production. The relationship between mitochondrial oxidative stress, ROS production, and mitophagy is closely intertwined and involved in various pathological conditions of acute kidney injury (AKI). The complex process of mitophagy in mammals involves multiple pathways and its interaction with different types of cell death, such as apoptosis, pyroptosis, and ferroptosis in kidney injury, remains unclear. This review discusses recent advances in understanding the relationship between ROS and mitophagy, the different pathways of mitophagy, the interplay between mitophagy and cell death, and their significance in the pathogenesis of AKI.

AUTOPHAGY (2023)

Review Physiology

THE PHYSIOLOGICAL FUNCTIONS OF HUMAN PEROXISOMES

Ronald J. A. Wanders et al.

Summary: Peroxisomes are subcellular organelles that play a crucial role in human physiology by catalyzing unique metabolic functions. They require the interaction with other organelles through tethering proteins to achieve efficient metabolite transfer. This review focuses on the metabolic role of peroxisomes in humans, discussing their partnership with other organelles, consequences of genetic defects, and their underrated role in viral infections.

PHYSIOLOGICAL REVIEWS (2023)

Article Biochemistry & Molecular Biology

NDP52 acts as a redox sensor in PINK1/Parkin-mediated mitophagy

Tetsushi Kataura et al.

Summary: Mitophagy is essential for maintaining cellular homeostasis. The best characterised pathway involves the stabilisation of PINK1 and recruitment of Parkin to damaged mitochondria. NDP52 recognises ubiquitinated mitochondrial proteins and initiates autophagic vesicle formation. This study found that oxidation of NDP52 is crucial for efficient PINK1/Parkin-dependent mitophagy, and proposed that redox sensing allows mitophagy to function as an oxidative stress response.

EMBO JOURNAL (2023)

Review Cell Biology

Full-coverage regulations of autophagy by ROS: from induction to maturation

Jing Zhou et al.

Summary: Autophagy is a well-conserved recycling process in response to stress, removing oxidized/damaged proteins and organelles to restrict further reactive oxygen species (ROS) production. Oxidative regulations occur throughout all stages of autophagy, including induction, nucleation, expansion, maturation, delivery and degradation, as well as gene transcription. Direct thiol oxidation of key proteins and certain chaperone-like proteins play roles in regulating different aspects of autophagy, while ROS can also inhibit autophagy through oxidation of key regulators.

AUTOPHAGY (2022)

Article Cell Biology

Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology

Helmut Sies et al.

Summary: This article discusses the key issues associated with identifying the physiological roles of oxidants, with a focus on H2O2 and O-2(.-). The article emphasizes the need for more precise measurement of oxidants and specific identification of their signaling targets. It also highlights the importance of inter-organellar communication and the contribution of environmental exposures. Development of tools for real-time detection and quantification of individual oxidants is crucial for achieving these goals.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2022)

Review Cell Biology

Emerging views of OPTN (optineurin) function in the autophagic process associated with disease

Yueping Qiu et al.

Summary: OPTN, as a well-recognized autophagy receptor, plays important roles in different stages of autophagy process. It is associated with various human disorders related to autophagy. Understanding the function of OPTN in autophagy provides valuable insights into the pathogenesis of autophagic diseases and can help in the discovery of potential therapeutic targets.

AUTOPHAGY (2022)

Article Cell Biology

Peroxisome-Derived Hydrogen Peroxide Modulates the Sulfenylation Profiles of Key Redox Signaling Proteins in Flp-In T-REx 293 Cells

Celien Lismont et al.

Summary: This study utilized a new approach to comprehensively and systematically analyze protein thiol targets of peroxisome-derived H2O2, identifying over 400 targets and observing variations in sulfenylation kinetics profiles of key targets from different protein families. Additionally, compelling indirect evidence was obtained suggesting that peroxisome-derived H2O2 may oxidize some targets through a redox relay mechanism, providing valuable insights into the integration of peroxisomes into the cellular H2O2 signaling network.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

Review Biochemistry & Molecular Biology

Life and Death Decisions-The Many Faces of Autophagy in Cell Survival and Cell Death

Ge Yu et al.

Summary: Autophagy is a conserved process in cell survival and cell death, enabling the degradation of cytoplasmic components. It has the primary role of delivering cytoplasmic components to vacuoles or lysosomes for degradation and can also regulate cell death in certain ways, with complex crosstalk between different pathways.

BIOMOLECULES (2022)

Article Cell Biology

Catalase-deficient mice induce aging faster through lysosomal dysfunction

Raghbendra Kumar Dutta et al.

Summary: This study investigated the role of catalase and lysosomal function in catalase-knockout mice, revealing that mature adult catalase-KO mice exhibited accelerated aging phenotypes compared to wild-type mice, with leaky lysosomes, impaired autophagy, and mTORC1 activation.

CELL COMMUNICATION AND SIGNALING (2022)

Article Biochemistry & Molecular Biology

Catalase deficiency induces reactive oxygen species mediated pexophagy and cell death in the liver during prolonged fasting

Raghbendra Kumar Dutta et al.

Summary: The study demonstrates that prolonged fasting in catalase-knockout mice significantly increases ROS production, leading to liver-specific pexophagy and cell death. The use of antioxidants and autophagy inhibitors can suppress the inflammatory response and disease progression.

BIOFACTORS (2021)

Review Cell Biology

The Peroxisome-Autophagy Redox Connection: A Double-Edged Sword?

Hongli Li et al.

Summary: Peroxisomes contain enzymes involved in H2O2 production and degradation. Dysfunctional peroxisomes are removed through pexophagy, while H2O2 plays a role in mediating autophagic processes. Understanding the bidirectional relationship between peroxisomal H2O2 metabolism and autophagy is a key challenge in studying autophagy-related disorders.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Multidisciplinary Sciences

Therapeutic concentrations of calcineurin inhibitors do not deregulate glutathione redox balance in human renal proximal tubule cells

Yasaman Ramazani et al.

Summary: The calcineurin inhibitors cyclosporine A and tacrolimus are essential in immunosuppressive treatment for solid organ transplantation, but long-term exposure can lead to renal damage. Previous studies suggest oxidative stress plays a role in CNI-associated nephrotoxicity, but use of high drug levels and inaccurate detection methods may lead to misleading results. New research using a proximal tubule cell model from human biopsies found no changes in glutathione redox balance at therapeutic concentrations, but oxidative imbalance was observed with cyclosporine A at supra-therapeutic levels.

PLOS ONE (2021)

Review Cell Biology

Mechanisms and Functions of Pexophagy in Mammalian Cells

Jing Li et al.

Summary: Peroxisomes play essential roles in cellular metabolism, and their dynamic homeostasis is maintained through biogenesis and turnover. Dysregulation of peroxisomes can lead to disease development, highlighting the importance of understanding pexophagy mechanisms.

CELLS (2021)

Review Cell Biology

Mechanisms of Selective Autophagy

Trond Lamark et al.

Summary: Selective autophagy is the degradation of specific intracellular components via selective autophagy receptors, which interact with autophagy-related proteins and may or may not depend on ubiquitin labeling of the cargo.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 37 (2021)

Article Biochemistry & Molecular Biology

Interactions between reactive oxygen species and autophagy Special issue: Death mechanisms in cellular homeostasis

Maureen Redza-Dutordoir et al.

Summary: Oxidative stress is defined as an imbalance between the generation of reactive oxygen species (ROS) and antioxidant defenses, causing excessive damage to biomolecules. Autophagy can regulate ROS levels through various pathways, such as activation of AMPK signaling cascade and ULK1 complex. Autophagy plays a crucial role in regulating oxidative stress by recycling damaged ROS-producing mitochondria.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2021)

Review Biochemistry & Molecular Biology

Redox metabolism: ROS as specific molecular regulators of cell signaling and function

Claudia Lennicke et al.

Summary: Redox reactions play a crucial role in energy metabolism and physiological functions of organisms. Reactive oxygen species (ROS), such as hydrogen peroxide, are important derivatives in normal aerobic metabolism. Hydrogen peroxide can modify protein activity by oxidizing cysteine residues, affecting enzyme and transcription factor functions and cellular processes.

MOLECULAR CELL (2021)

Review Cell Biology

Oligomerization of Selective Autophagy Receptors for the Targeting and Degradation of Protein Aggregates

Wenjun Chen et al.

Summary: This article summarizes the mechanisms of action of receptors in selective protein aggregate autophagy and recent research progress, with a particular focus on how oligomerization of receptors affects pathway determinants and promotes phase separation.

CELLS (2021)

Article Endocrinology & Metabolism

Organelle interplay-peroxisome interactions in health and disease

Michael Schrader et al.

JOURNAL OF INHERITED METABOLIC DISEASE (2020)

Review Biochemistry & Molecular Biology

Roles of Autophagy in Oxidative Stress

Hyeong Rok Yun et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Cell Biology

Slc25a17 Gene Trapped Mice: PMP34 Plays a Role in the Peroxisomal Degradation of Phytanic and Pristanic Acid

Paul P. Van Veldhoven et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Review Biochemistry & Molecular Biology

Complex interplay between autophagy and oxidative stress in the development of pulmonary disease

Wojciech Ornatowski et al.

REDOX BIOLOGY (2020)

Article Multidisciplinary Sciences

Hsc70/Stub1 promotes the removal of individual oxidatively stressed peroxisomes

Bo-Hua Chen et al.

NATURE COMMUNICATIONS (2020)

Review Biochemistry & Molecular Biology

Redox Signaling from and to Peroxisomes: Progress, Challenges, and Prospects

Marc Fransen et al.

ANTIOXIDANTS & REDOX SIGNALING (2019)

Article Multidisciplinary Sciences

Pejvakin-mediated pexophagy protects auditory hair cells against noise-induced damage

Jean Defourny et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Review Biochemistry & Molecular Biology

Peroxisomal Hydrogen Peroxide Metabolism and Signaling in Health and Disease

Celien Lismont et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Biochemistry & Molecular Biology

Peroxisomes as Modulators of Cellular Protein Thiol Oxidation: A New Model System

Celien Lismont et al.

ANTIOXIDANTS & REDOX SIGNALING (2019)

Editorial Material Cell Biology

Regulation of autophagic proteolysis by the N-recognin SQSTM1/p62 of the N-end rule pathway

Hyunjoo Cha-Molstad et al.

AUTOPHAGY (2018)

Article Biochemistry & Molecular Biology

Catalase inhibition induces pexophagy through ROS accumulation

Joon No Lee et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Article Biochemistry & Molecular Biology

Dual role of USP30 in controlling basal pexophagy and mitophagy

Elena Marcassa et al.

EMBO REPORTS (2018)

Review Cell Biology

Cargo recognition and degradation by selective autophagy

Damian Gatica et al.

NATURE CELL BIOLOGY (2018)

Article Multidisciplinary Sciences

Oxidation of Atg3 and Atg7 mediates inhibition of autophagy

Karen Frudd et al.

NATURE COMMUNICATIONS (2018)

Article Multidisciplinary Sciences

Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis

Bernadette Carroll et al.

NATURE COMMUNICATIONS (2018)

Review Cell Biology

Mechanisms of mitophagy in cellular homeostasis, physiology and pathology

Konstantinos Palikaras et al.

NATURE CELL BIOLOGY (2018)

Review Biochemistry & Molecular Biology

The Peroxisome-Mitochondria Connection: How and Why?

Marc Fransen et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Article Biochemistry & Molecular Biology

The pharmacological regulation of cellular mitophagy

Nikolaos D. Georgakopoulos et al.

NATURE CHEMICAL BIOLOGY (2017)

Article Biochemistry & Molecular Biology

The peroxisomal import receptor PEX5 functions as a stress sensor, retaining catalase in the cytosol in times of oxidative stress

Paul A. Walton et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2017)

Article Cell Biology

PEX2 is the E3 ubiquitin ligase required for pexophagy during starvation

Graeme Sargent et al.

JOURNAL OF CELL BIOLOGY (2016)

Article Biochemistry & Molecular Biology

Pexophagy is induced by increasing peroxisomal reactive oxygen species in 1′10-phenanthroline-treated cells

Doo Sin Jo et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

Article Cell Biology

ATM functions at the peroxisome to induce pexophagy in response to ROS

Jiangwei Zhang et al.

NATURE CELL BIOLOGY (2015)

Article Cell Biology

USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria

Christian N. Cunningham et al.

NATURE CELL BIOLOGY (2015)

Review Biochemistry & Molecular Biology

The Role of Lipids in the Control of Autophagy

Claudia Dall'Armi et al.

CURRENT BIOLOGY (2013)

Article Chemistry, Physical

How Does the Environment Affect the Absorption Spectrum of the Fluorescent Protein mKeima?

Marc Nadal-Ferret et al.

JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2013)

Article Microscopy

Potential limitations in the use of KillerRed for fluorescence microscopy

M. Nordgren et al.

JOURNAL OF MICROSCOPY (2012)

Review Cell Biology

Canonical and non-canonical autophagy: variations on a common theme of self-eating?

Patrice Codogno et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)

Article Cell Biology

Intraperoxisomal redox balance in mammalian cells: oxidative stress and interorganellar cross-talk

Oksana Ivashchenko et al.

MOLECULAR BIOLOGY OF THE CELL (2011)

Article Multidisciplinary Sciences

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

Angela Alexander et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Biochemistry & Molecular Biology

FoxO Transcription Factors Promote Autophagy in Cardiomyocytes

Arunima Sengupta et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Proximity-based Protein Thiol Oxidation by H2O2-scavenging Peroxidases

Marcus Gutsche et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Chemistry, Multidisciplinary

Reverse pH-Dependence of Chromophore Protonation Explains the Large Stokes Shift of the Red Fluorescent Protein mKeima

Sebastien Violot et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)

Article Cell Biology

Peroxisome Dynamics in Cultured Mammalian Cells

Sofie J. Huybrechts et al.

TRAFFIC (2009)

Article Multidisciplinary Sciences

Ubiquitin signals autophagic degradation of cytosolic proteins and peroxisomes

Peter Kijun Kim et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Pharmacology & Pharmacy

Progeric effects of catalase inactivation in human cells

Jay I. Koepke et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2008)

Article Biochemistry & Molecular Biology

Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells

Y. Chen et al.

CELL DEATH AND DIFFERENTIATION (2008)

Article Cell Biology

Oxidation as a post-translational modification that regulates autophagy

Ruth Scherz-Shouval et al.

AUTOPHAGY (2007)

Article Biochemistry & Molecular Biology

Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4

Ruth Scherz-Shouval et al.

EMBO JOURNAL (2007)

Review Biochemistry & Molecular Biology

The redox regulation of PI 3-kinase-dependent signaling

Nick R. Leslie

ANTIOXIDANTS & REDOX SIGNALING (2006)

Article Cell Biology

Peroxisome senescence in human fibroblasts

JE Legakis et al.

MOLECULAR BIOLOGY OF THE CELL (2002)